Ultracentrifugal study of effect of sodium chloride on micelle size of fusidate sodium.

Abstract:

:Apparent micellar molecular weights were determined with the antibiotic fusidate sodium by ultracentrifugation in varying counterion concentrations (Na+). The effects of buffer salts, pH, sodium chloride concentration, and drug concentration were studied. The results strongly support the concept of the formation of primary micelles composed of five monomer units, followed by aggregation of the pentomers into larger micelles as salt concentration increases.

journal_name

J Pharm Sci

authors

Richard AJ

doi

10.1002/jps.2600640536

subject

Has Abstract

pub_date

1975-05-01 00:00:00

pages

873-5

issue

5

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)40175-3

journal_volume

64

pub_type

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