Ultracentrifugal study of effect of sodium chloride on micelle size of fusidate sodium.


:Apparent micellar molecular weights were determined with the antibiotic fusidate sodium by ultracentrifugation in varying counterion concentrations (Na+). The effects of buffer salts, pH, sodium chloride concentration, and drug concentration were studied. The results strongly support the concept of the formation of primary micelles composed of five monomer units, followed by aggregation of the pentomers into larger micelles as salt concentration increases.


J Pharm Sci


Richard AJ




Has Abstract


1975-05-01 00:00:00














  • Development and Evaluation of a Novel Drug Delivery: Pluronics/SDS Mixed Micelle Loaded With Myricetin In Vitro and In Vivo.

    abstract::This study is to prepare and evaluate Pluronics-modified mixed micelle (MM) to deliver polyphenolic myricetin (MYR) across the blood-brain barrier. MYR has been proven to be an effective anticancer agent against glioblastoma cells in our previous studies. However, the poor solubility of MYR limits its access to the br...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wang G,Wang JJ,Li F,To SS

    更新日期:2016-04-01 00:00:00

  • Transcellular route of diffusion through stratum corneum: results from finite element models.

    abstract::Insight into the stratum corneum (SC) permeation pathway for hydrophilic compounds is gained by comparing experimental measurements of permeability and lag time (tlag) with the predictions of a finite element (FE) model. A database of permeability and lag time measurements (n=27) of hydrophilic compounds was compiled ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Barbero AM,Frasch HF

    更新日期:2006-10-01 00:00:00

  • Differentiation of subvisible silicone oil droplets from irregular standard dust particles.

    abstract::New methods are being applied to distinguish silicone oil droplets from subvisible particles in therapeutic protein formulations. The need to standardize these methods and compare them to established methods is critical to increase the understanding of the risks from protein aggregation and other subvisible particulat...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Vandesteeg N,Kilbert C

    更新日期:2013-06-01 00:00:00

  • Improved delivery through biological membranes XD: Percutaneous absorption and metabolism of methylsulfinylmethyl 2-acetoxybenzoate and related aspirin prodrugs.

    abstract::Oxidative-reductive interconversion of the methylthiomethyl ester of aspirin and the corresponding sulfoxide and sulfone derivatives can be detected in rat liver homogenate, in addition to the extremely facile hydrolysis of these esters. The methylthiomethyl and methylsulfinylmethyl 2-acetoxybenzoates penetrate freshl...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Loftsson T,Bodor N

    更新日期:1981-07-01 00:00:00

  • In situ monitoring of polymorph transformation of clopidogrel hydrogen sulfate using measurement of ultrasonic velocity.

    abstract::Transformation of polymorph I of clopidogrel hydrogen sulfate (CHS) to polymorph II of CHS during the crystallization was monitored by using in situ measurement of ultrasonic velocity. Drowning-out crystallization using methanol as a solvent and isopropyl alcohol as nonsolvent was carried out. The polymorphs were iden...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kim HJ,Kim KJ

    更新日期:2008-10-01 00:00:00

  • Decomposition of alpha-hydroxyaryl ketones and characterization of some unusual products.

    abstract::Alpha-Hydroxyaryl ketones such as 2-hydroxypropiophenone and 1-(2,4-difluorophenyl)-2-hydroxy-1-propanone, the key intermediates in the preparation of antifungal agents, decompose into oxidized, rearranged, and condensed products. These products were isolated and characterized. The possible mechanisms for the formatio...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Gala D,Puar MS,Das PR,Kugelman M,DiBenedetto DJ

    更新日期:1992-12-01 00:00:00

  • Rotigotine: Unexpected Polymorphism with Predictable Overall Monotropic Behavior.

    abstract::Crystallization of polymorphs still has a touch of art, as even prior observations of polymorphs do not guarantee their crystallization. However, once crystals of various polymorphs have been obtained, their relative stabilities can be established with a straightforward thermodynamic approach even if the conclusion wi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Rietveld IB,Céolin R

    更新日期:2015-12-01 00:00:00

  • High-Throughput Melanin-Binding Affinity and In Silico Methods to Aid in the Prediction of Drug Exposure in Ocular Tissue.

    abstract::Drugs possessing the ability to bind to melanin-rich tissue, such as the eye, are linked with higher ocular exposure, and therefore have the potential to affect the efficacy and safety profiles of therapeutics. A high-throughput melanin chromatographic affinity assay has been developed and validated, which has allowed...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Reilly J,Williams SL,Forster CJ,Kansara V,End P,Serrano-Wu MH

    更新日期:2015-12-01 00:00:00

  • Relative and absolute bioavailability of cibenzoline capsules and tablets in healthy subjects.

    abstract::Eighteen healthy adult volunteers completed an open-label, four-way crossover study designed to determine the bioequivalency of 160-mg cibenzoline [2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole] capsules and tablets, their relative bioavailability compared with an oral solution of the drug, as well as the absol...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Massarella J,Silvestri T,Lin A

    更新日期:1986-09-01 00:00:00

  • In vitro binding of chloroquine to rat muscle preparations.

    abstract::Chloroquine (7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline; CQ) accumulates in the insoluble fraction of rat muscle homogenates with an equilibrium distribution ratio of 7.8 L/kg. This is of a similar magnitude to muscle:plasma ratios observed in vivo. Uptake is approximately linear, even up to concentra...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: MacIntyre AC,Cutler DJ

    更新日期:1986-11-01 00:00:00

  • Determination of coumarin and umbelliferone mixtures in whole blood by spectrophotofluorometry.

    abstract::A spectrophotofluorometric method is described for the quantitative analysis of coumarin, umbelliferone, and mixtures thereof in whole blood. The two drugs were selectively isolated from blood by solvent extraction. Analysis of the isolated coumarin was based on the measurement of the fluorophore at activation and emi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tan HS,Ritschel WA,Sanders PR

    更新日期:1976-01-01 00:00:00

  • Molecular Dynamics of Amorphous Sulfamethazine With Structurally Related Sulfonamide Impurities Evaluated Using Thermal Analysis.

    abstract::In this study, the effects of structurally related organic impurities on the molecular dynamics of amorphous sulfamethazine were evaluated using thermal analysis. Sulfanilamide (SNA), sulfamerazine (SMR), and sulfadimethoxine were used as virtual impurities of sulfamethazine. The amorphous state was prepared in situ i...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hamada Y,Ono M,Ohara M,Yonemochi E

    更新日期:2017-04-01 00:00:00

  • A method to predict the equilibrium solubility of drugs in solid polymers near room temperature using thermal analysis.

    abstract::A method is presented for determining the equilibrium solubility of a drug in a solid polymer at or near room temperature, which represents a typical storage temperature. The method is based on a thermodynamic model to calculate the Gibbs energy change ΔG(SS) associated with forming a binary drug-polymer solid solutio...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bellantone RA,Patel P,Sandhu H,Choi DS,Singhal D,Chokshi H,Malick AW,Shah N

    更新日期:2012-12-01 00:00:00

  • Intrinsic factor-mediated binding of cyanocobalamin to cholestyramine.

    abstract::The intrinsic factor-mediated binding of cyanocobalamin to cholestyramine was studied in vitro under varying conditions of pH, added electrolyte, and bile salt. The intrinsic factor-cyanocobalamin complex was adsorbed strongly by the resin at pH 3 in the presence of neutral salt and low concentrations of glycocholic a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Andersen KJ,Schjønsby H

    更新日期:1978-11-01 00:00:00

  • A new natural angelica polysaccharide based colon-specific drug delivery system.

    abstract::Colon-specific drug delivery systems are clinically necessary to treat colon diseases locally while minimizing systemic side effects. In this study, we extracted angelica polysaccharide from fresh roots of Angelica sinensis Diels and analyzed the monosaccharide components. With succinate as a cross-linker and angelica...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Zhou S,Zhang B,Liu X,Teng Z,Huan M,Yang T,Yang Z,Jia M,Mei Q

    更新日期:2009-12-01 00:00:00

  • Stereochemistries of geometric isomers of 4-(2-bromo-1,2-diphenylvinyl)phenol, 4-(2-bromo-1,2-diphenyylamine: corrections of the literature.

    abstract::The stereochemistries of geometric isomers of 4-(2-bromo-1,2-diphenylvinyl)phenol, 4-(2-bromo-1,2-diphenylvinyl)anisole, and 2-[p-(2-bromo-1,2-diphenylvinyl)phenoxy]triethylamine were determined by conversion of the phenolic analog to the ethers and subsequent comparison of physical properties with those of 2-[p-(2-ch...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Richardson A Jr,Benson HD,Hite G

    更新日期:1976-10-01 00:00:00

  • Formulation approaches to short interfering RNA and MicroRNA: challenges and implications.

    abstract::RNA interference has emerged as a potentially powerful tool in the treatment of genetic and acquired diseases by delivering short interfering RNA (siRNA) or microRNA (miRNA) to target genes, resulting in their silencing. However, many physicochemical and biological barriers have to be overcome to obtain efficient in v...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Guzman-Villanueva D,El-Sherbiny IM,Herrera-Ruiz D,Vlassov AV,Smyth HD

    更新日期:2012-11-01 00:00:00

  • Interlaboratory comparison of analytical methods for residual ethylene oxide at low concentration levels in medical device materials.

    abstract::An interlaboratory comparison of two extraction methods and one thermal desorption test method for the quantification of ethylene oxide (EO) by gas chromatography in two common medical device materials, high density polyethylene (HDPE) and plasticized polyvinyl chloride (PVC), was conducted by 15 laboratories. The thr...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lao NT,Lu HT,Rego A,Kosakowski RH,Burgess DJ,Hume RD

    更新日期:1995-05-01 00:00:00

  • Effect of uridine diphospho-N-acetylglucosamine and sodium salicylate on L-glutamine-D-fructose-6-phosphate aminotransferase activity from rat gastric mucosa.

    abstract::Mechanisms of inhibitory action of sodium salicylate on L-glutamine-D-fructose-6-phosphate aminotransferase, prepared from rat gastric mucosa, were studied. Sodium salicylate at lower concentrations (10-20 mM) inhibited reversibly aminotransferase activity by competing with fructose-6-phosphate. At higher concentratio...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chan J,Lee KH

    更新日期:1975-07-01 00:00:00

  • Exploring a Kinetic Model Approach in Biopharmaceutics: Estimating the Fraction Absorbed of Orally Administered Drugs in Humans.

    abstract::Increasing costs of research and development in the pharmaceutical industry has necessitated a growing interest in the early prediction of human pharmacokinetics of drug candidates. Of growing interest is the need to understand oral absorption, the most common route of small molecule drug administration. The fraction ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chiang PC,Liu J,Fan P,Wong H

    更新日期:2018-07-01 00:00:00

  • Drug delivery via the mucous membranes of the oral cavity.

    abstract::The delivery of drugs via the mucous membranes lining the oral cavity (i.e., sublingual and buccal), with consideration of both systemic delivery and local therapy, is reviewed in this paper. The structure and composition of the mucosae at different sites in the oral cavity, factors affecting mucosal permeability, pen...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Harris D,Robinson JR

    更新日期:1992-01-01 00:00:00

  • Ophthalmic Econazole Hydrogels for the Treatment of Fungal Keratitis.

    abstract::Econazole is a feasible alternative treatment in the management of fungal keratitis. Nevertheless, its low water solubility is considered the main limitation to the incorporation into ophthalmic formulations. In this work, econazole nitrate is solubilized by using cyclodextrins to achieve an optimum therapeutic concen...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Díaz-Tomé V,Luaces-Rodríguez A,Silva-Rodríguez J,Blanco-Dorado S,García-Quintanilla L,Llovo-Taboada J,Blanco-Méndez J,García-Otero X,Varela-Fernández R,Herranz M,Gil-Martínez M,Lamas MJ,González-Barcia M,Otero-Espinar FJ,Fern

    更新日期:2018-05-01 00:00:00

  • Pairwise polymer blends for oral drug delivery.

    abstract::Blends of polymers with complementary properties hold promise for addressing the diverse, demanding polymer performance requirements in amorphous solid dispersions (ASDs), but we lack comprehensive property understanding for blends of important ASD polymers. Herein, we prepare pairwise blends of commercially available...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Marks JA,Wegiel LA,Taylor LS,Edgar KJ

    更新日期:2014-09-01 00:00:00

  • Adhesive tablet effective for treating canker sores in humans.

    abstract::A new mucoadhesive tablet, which releases natural active agents for pain reduction and rapid healing of canker sores, has been prepared and characterized. Adhesive tablets were prepared by compression molding of mixed powders of crosslinked polyacrylic acid and hydroxypropyl cellulose, absorbed with citrus oil and mag...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 临床试验,杂志文章


    authors: Mizrahi B,Golenser J,Wolnerman JS,Domb AJ

    更新日期:2004-12-01 00:00:00

  • Synthesis and bioevaluation of a series of fatty acid esters of p-[N,N-bis(2-chloroethyl)amino]phenol.

    abstract::A series of even numbered fatty acid esters (C2-C18) of p-[N,N-bis(2-chloroethyl)amino]phenol were synthesized and evaluated as to acute toxicity as well as effectiveness against L-1210 mouse leukemia. The acetate through the decanoate derivatives demonstrated toxicity between 2 and 3 times that of phenol mustard in H...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wynn JE,Caldwell ML,Robinson JR,Beamer RL,Bauguess CT

    更新日期:1982-07-01 00:00:00

  • Improved techniques for the photometric determination of partition coefficients, with particular reference to the chloroform-ammonia solvent system.

    abstract::Accurate partition coefficients K = Corg/Caq in chloroform-ammonia can be obtained by measuring the absorbance of the aqueous layer, replenishing with fresh aqueous solvent, and remeasuring the absorption after reequilibration. Provided the solute has a reasonably strong UV absorption, only 0.1-5 mg of material is req...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Rummens FH,Bujaczek RF,Peters M,Green RD

    更新日期:1984-02-01 00:00:00

  • Primary Human Hepatocyte Spheroid Model as a 3D In Vitro Platform for Metabolism Studies.

    abstract::3D cultures of primary human hepatocytes (PHH) are emerging as a more in vivo-like culture system than previously available hepatic models. This work describes the characterisation of drug metabolism in 3D PHH spheroids. Spheroids were formed from three different donors of PHH and the expression and activities of impo...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kanebratt KP,Janefeldt A,Vilén L,Vildhede A,Samuelsson K,Milton L,Björkbom A,Persson M,Leandersson C,Andersson TB,Hilgendorf C

    更新日期:2021-01-01 00:00:00

  • Dequaternization of curare bases with sodium thiophenoxide and ethanolamine.

    abstract::To prepare (+)-tubocurine and O,O-dimethyl-(+)-tubocurine, the commonly used dequaternization procedures with sodium theophenoxide and ethanolamine were investigated. The quaternary compounds were (+)-tubocurarine chloride and the chloride and iodide salts of O,O-dimethyl-(+)-chondocurarine. The results obtained with ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Naghaway JA,Soine TO

    更新日期:1978-09-01 00:00:00

  • Controlled transdermal delivery of fentanyl: characterizations of pressure-sensitive adhesives for matrix patch design.

    abstract::Transdermal delivery of fentanyl from various adhesive matrix formulations to achieve a steady-state skin flux was investigated. For this purpose, various pressure-sensitive adhesives selected from the three chemical classes of polymers (polyisobutylene (PIB), acrylate, and silicone adhesives) were characterized with ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Roy SD,Gutierrez M,Flynn GL,Cleary GW

    更新日期:1996-05-01 00:00:00

  • Unified physicochemical property estimation relationships (UPPER).

    abstract::The knowledge of physicochemical properties of organic compounds becomes increasingly important in pharmaceutical sciences, chemical engineering, and other fields. In this study, we developed UPPER (Unified Physicochemical Property Estimation Relationships), a comprehensive model for the estimation of 20 physicochemic...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lian B,Yalkowsky SH

    更新日期:2014-09-01 00:00:00