Epimeric 5-hydroxy-5-phenyl-1-azabicyclo [5.4.0] undecanes.


:The development of order during the aging of aluminum hydroxide gel prepared by the reaction of aluminum chloride and ammonium hydroxide to a final pH of 7.0 can be monitored by differential thermal analysis. The loss fo acid reactivity upon aging is accompanied by an increase in the temperature and intensity of the dehydroxylation endotherm and an accompanying decrease in the intensity of the water of hydration endotherm. With continued aging, the thermogram develops the characteristics of a crystalline aluminum hydroxide.


J Pharm Sci


Aboul-Enein N,Sam J




Has Abstract


1976-09-01 00:00:00














  • Synthesis, cytotoxicity, hypolipidemic and anti-inflammatory activities of amine-boranes and esters of boron analogues of choline and thiocholine.

    abstract::Boron analogues of carbamoylcholine and thiocholine and esters of these analogues were prepared. These compounds were fairly stable toward hydrolysis and demonstrated moderate anti-inflammatory and hypolipidemic activities in mice. The hypolipidemic activity of the compounds at a dose of 8 mg/kg/day was equivalent in ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sood A,Sood CK,Spielvogel BF,Hall IH,Wong OT

    更新日期:1992-05-01 00:00:00

  • High-performance frontal analysis-high-performance liquid chromatographic system for stereoselective determination of unbound ketoprofen enantiomers in plasma after direct sample injection.

    abstract::An on-line, high-performance frontal analysis (HPFA)-high-performance liquid chromatographic system was developed for the enantioselective determination of a low level of unbound ketoprofen (KP) that is in equilibrium with KP that is bound to protein. The system consists of three subsystems (HPFA system, preconcentrat...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Shibukawa A,Terakita A,He JY,Nakagawa T

    更新日期:1992-07-01 00:00:00

  • MDR1 haplotypes significantly minimize intracellular uptake and transcellular P-gp substrate transport in recombinant LLC-PK1 cells.

    abstract::To date, research on the effect of single nucleotide polymorphisms (SNPs) on P-glycoprotein (P-gp) expression and functionality has rendered inconsistent results. This study systematically evaluates the impact of MDR1 haplotypes (1236/2677, 1236/3435, 2677/3435, 1236/2677/3435) on P-gp functionality compared to indivi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Salama NN,Yang Z,Bui T,Ho RJ

    更新日期:2006-10-01 00:00:00

  • Influence of pH, temperature, and buffers on the kinetics of ceftazidime degradation in aqueous solutions.

    abstract::First-order rate constants (k) were determined for the hydrolysis of ceftazidime in the pH range of 0.5 to 8.5 at 45, 55, and 65 degrees C by a stability-indicating HPLC assay. In the absence of buffer effects, the pH-rate expression was k = kH1f1(aH+) + kH2f2(aH+) + kH3f3(aH+) + kSf3 + kOHf3(aOH-), where KH and KOH a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Zhou M,Notari RE

    更新日期:1995-05-01 00:00:00

  • Determination of polymorph conversion of an active pharmaceutical ingredient in wet granulation using NIR calibration models generated from the premix blends.

    abstract::Near infrared (NIR) spectroscopy was used for quantitatively monitoring polymorph conversion of an active pharmaceutical ingredient (API) in wet granulation. The API under pharmaceutical development has two different polymorphs. Polymorph A is the stable form for drug development and polymorph B is the undesired form ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Li W,Worosila GD,Wang W,Mascaro T

    更新日期:2005-12-01 00:00:00

  • Adhesive tablet effective for treating canker sores in humans.

    abstract::A new mucoadhesive tablet, which releases natural active agents for pain reduction and rapid healing of canker sores, has been prepared and characterized. Adhesive tablets were prepared by compression molding of mixed powders of crosslinked polyacrylic acid and hydroxypropyl cellulose, absorbed with citrus oil and mag...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 临床试验,杂志文章


    authors: Mizrahi B,Golenser J,Wolnerman JS,Domb AJ

    更新日期:2004-12-01 00:00:00

  • Use of parenteral dipeptides to increase serum tyrosine levels and to enhance catecholamine-mediated neurotransmission.

    abstract::The use of intravascular tyrosine (TYR) to enhance catecholamine release in hemorrhagic shock and other cardiovascular diseases, or as a constituent of nutrient mixtures used for total parenteral nutrition, is limited by the unusually poor solubility of the amino acid in water. We have thus examined the ability of var...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Maher TJ,Kiritsy PJ,Moya-Huff FA,Casacci F,De Marchi F,Wurtman RJ

    更新日期:1990-08-01 00:00:00

  • Simultaneous automated determination of spironolactone metabolites in serum.

    abstract::An automated two-phase method for the simultaneous fluorometric determination of the spironolactone metabolites canrenone (II) and canrenoic acid (III) in serum is described. The determination is performed by two dichloroethane extractions of the same serum sample at different pH values. The fluorescence developed in ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Neubert P,Koch K

    更新日期:1977-08-01 00:00:00

  • PEGylation as a tool for the biomedical engineering of surface modified microparticles.

    abstract::Microparticles are of considerable interest for drug delivery, vaccination and diagnostic imaging. In order to obtain microparticles with long circulation times, or to provide the prerequisite for tissue specific targeting through decoration with suitable ligands, their surfaces need to be modified such that they beco...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Wattendorf U,Merkle HP

    更新日期:2008-11-01 00:00:00

  • Potency of synthetic luteinizing hormone releasing hormone preparations in rat anterior pituitary cell cultures.

    abstract::Selected synthetic luteinizing hormone releasing hormone preparations were assayed, and their potencies were determined relative to one sample utilizing primary cultures of enzymatically dispersed rat anterior pituitary cells. Preliminary cell culture experiments indicated that luteinizing hormone releasing hormone ha...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Dermody WC,Pastushok CA,Sakowski R,Vaitkus JW,Reel JR

    更新日期:1977-03-01 00:00:00

  • Preparation of spherically agglomerated crystals of aminophylline.

    abstract::The spherically agglomerated crystals of aminophylline (theophylline-ethylenediamine complex) can be compounded directly into pharmaceutical formulations without further processing, e.g., granulation. Such crystals were prepared by mixing theophylline and ethylenediamine in a partially miscible solvent system, i.e., o...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kawashima Y,Aoki S,Takenaka H,Miyake Y

    更新日期:1984-10-01 00:00:00

  • Constant blood withdrawal method for area under plasma concentration-time curve.

    abstract::The area under the plasma concentration-time curve (AUC) was measured after an intravenous injection of sodium salicylate and after intragastric administration of aspirin, using either an intermittent sampling and the trapezoid rule (AUC-trapezoid) or the recently introduced constant blood withdrawal method (AUC-integ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kowarski CR,Kowarski AA

    更新日期:1978-06-01 00:00:00

  • A rapid HPLC method for the quantification of tyrothricin, menthol, and benzocaine in pharmaceutical formulations.

    abstract::A rapid, sensitive, and accurate reversed-phase HPLC method has been developed for the analysis and quantification of pharmaceutical formulations containing tyrothricin (1), an antibiotic used in antiseptic buccal compressed tablets for local application. The assay has been carried out under isocratic conditions, usin...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Caraballo I,Fernandez-Arevalo M,Holgado MA,Vela MT,Rabasco AM

    更新日期:1994-08-01 00:00:00

  • Systematic Evaluation of Wajima Superposition (Steady-State Concentration to Mean Residence Time) in the Estimation of Human Intravenous Pharmacokinetic Profile.

    abstract::We present a systematic evaluation of the Wajima superpositioning method to estimate the human intravenous (i.v.) pharmacokinetic (PK) profile based on a set of 54 marketed drugs with diverse structure and range of physicochemical properties. We illustrate the use of average of "best methods" for the prediction of cle...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lombardo F,Berellini G,Labonte LR,Liang G,Kim S

    更新日期:2016-03-01 00:00:00

  • Analysis of tricyclic antidepressants in human plasma by GLC--chemical-ionization mass spectrometry with selected ion monitoring.

    abstract::A method is described for the analysis of amitriptyline, doxepin, imipramine, nortriptyline, desmethyldoxepin, desipramine, and protriptyline in human plasma utlizing GLC-chemical-ionization mass spectrometry with selected ion monitoring. The assay is highly specific and is quantitative to at least 1 ng/ml with a stan...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Jenkins RG,Friedel RO

    更新日期:1978-01-01 00:00:00

  • Crystal Structures and Vapor-Induced Crystalline Transformation of 7-Ethyl-10-Hydroxycamptothecin Pseudopolymorphs.

    abstract::Solvent-induced 3 frameworks (the monohydrate, methanol solvate, and dimethyl formamide [DMF] solvate) of an anticancer drug, 7-ethyl-10-hydroxycamptothecin (SN38), were constructed. The crystal structures of the 3 pseudopolymorphs were characterized by single-crystal X-ray diffraction technique for the first time. Cr...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Fang L,Wang L,Yao C,Song S,Wu Z,Tao X

    更新日期:2017-10-01 00:00:00

  • Kinetics and mechanism of oxidation of promazine and promethazine by ferric perchlorate.

    abstract::The equilibrium constants, kinetics, and mechanism of promazine and promethazine oxidation by ferric perchlorate were investigated at different temperatures and acidities using a stopped-flow spectrophotometric technique. The overall reaction can be represented as follows: (formula: see text) where P+ represents the r...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Gasco MR,Carlotti ME

    更新日期:1978-02-01 00:00:00

  • On the influence of protein binding on pharmacological activity of drugs.

    abstract::The effect of variable protein binding (taken as independent parameter) on pharmacological activity of drugs is considered in terms of the exposure or the steady state concentration of unbound drug at targeted tissue. Based on the application of the parallel tube or dispersion models it is shown that for the most comm...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Berezhkovskiy LM

    更新日期:2010-04-01 00:00:00

  • Quantitative flash-methylation analysis of phenobarbital.

    abstract::In phenobarbital measurement by GLC with the flash-methylation technique, using trimethylanilinium hydroxide as a methylating reagent, a small amount of water decomposed phenobarbital and interfered with the quantitative analysis. Thus, both the sample and the methylating reagent must be sufficiently dehydrated to att...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kurata K,Takeuchi M,Yoshida K

    更新日期:1979-09-01 00:00:00

  • Slow motion picture of protein inactivation during single-droplet drying: a study of inactivation kinetics of L-glutamate dehydrogenase dried in an acoustic levitator.

    abstract::A novel technique is presented to allow measurement of the kinetics of protein inactivation during drying of an acoustically levitated single droplet. Droplets/particles are removed from the acoustic field after various times during drying, and the state of the protein within them is analyzed. The influence of drying ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lorenzen E,Lee G

    更新日期:2012-06-01 00:00:00

  • PTL401, a New Formulation Based on Pro-Nano Dispersion Technology, Improves Oral Cannabinoids Bioavailability in Healthy Volunteers.

    abstract::There is a growing clinical interest in developing and commercializing pharmaceutical-grade cannabinoid products, containing primarily tetrahydrocannabinol (THC) and cannabidiol (CBD). The oral bioavailability of THC and CBD is very low due to extensive "first-pass" metabolism. A novel oral THC and CBD formulation, PT...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Atsmon J,Cherniakov I,Izgelov D,Hoffman A,Domb AJ,Deutsch L,Deutsch F,Heffetz D,Sacks H

    更新日期:2018-05-01 00:00:00

  • Flecainide acetate acetic acid solvates.

    abstract::Flecainide acetate forms acetic acid solvates with 0.5 and 2 acetic acid molecules. Powder X-ray diffraction, differential thermal analysis/thermogravimetric, infrared, and potentiometric titration were used to determine the composition of solvates. Flecainide acetate hemisolvate with acetic acid decomposes to form a ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Veldre K,Actiņs A,Eglite Z

    更新日期:2011-02-01 00:00:00

  • A sensitive high-pressure liquid chromatography/particle beam/mass spectrometry assay for the determination of all-trans-retinoic acid and 13-cis-retinoic acid in human plasma.

    abstract::A highly sensitive assay for the measurement of all-trans-retinoic acid (tretinoin) and 13-cis-retinoic acid (isotretinoin) has been developed. Collected plasma samples were protein precipitated with 2-propanol followed by solid phase extraction. The retinoic acids were subsequently derivatized to their pentafluoroben...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lehman PA,Franz TJ

    更新日期:1996-03-01 00:00:00

  • In vitro and in vivo availability of commercial prednisone tablets.

    abstract::A three-way crossover bioavailability study was performed using nine adult male volunteers with three different commercial prednisone tablets. Plasma samples were assayed for prednisolone, the active metabolite of prednisone, by a radioimmunoassay method. Statistical analysis showed significant differences in the rate...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 临床试验,杂志文章


    authors: Sullivan TJ,Sakmar E,Albert KS,Blair DC,Wagner JG

    更新日期:1975-10-01 00:00:00

  • Development of Novel Drug and Gene Delivery Carriers Composed of Single-Walled Carbon Nanotubes and Designed Peptides With PEGylation.

    abstract::Single-walled carbon nanotubes (SWCNTs) attract great interest in biomedical applications including drug and gene delivery. In this study, we developed a novel delivery system using SWCNTs associated with designed polycationic and amphiphilic peptides. Wrapping of SWCNTs with H-(-Lys-Trp-Lys-Gly-)7-OH [(KWKG)7] result...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ohta T,Hashida Y,Yamashita F,Hashida M

    更新日期:2016-09-01 00:00:00

  • Relationship between the crystallization rates of amorphous nifedipine, phenobarbital, and flopropione, and their molecular mobility as measured by their enthalpy relaxation and (1)H NMR relaxation times.

    abstract::Isothermal crystallization of amorphous nifedipine, phenobarbital, and flopropione was studied at temperatures above and below their glass transition temperatures (T(g)). A sharp decrease in the crystallization rate with decreasing temperature was observed for phenobarbital and flopropione, such that no crystallizatio...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Aso Y,Yoshioka S,Kojima S

    更新日期:2000-03-01 00:00:00

  • Improved transnasal transport and brain uptake of tizanidine HCl-loaded thiolated chitosan nanoparticles for alleviation of pain.

    abstract::The aim of this study was to prepare and characterize thiolated chitosan (TC) nanoparticles (NPs) of tizanidine HCl (TZ) and to evaluate its transport across monolayer of RPMI 2650 cells (Human nasal septum carcinoma cell line) followed by assessment of their pharmacokinetic and pharmacodynamic attributes, after intra...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Patel D,Naik S,Misra A

    更新日期:2012-02-01 00:00:00

  • Distribution of gacyclidine enantiomers after experimental spinal cord injury in rats: possible involvement of an active transport system.

    abstract::The pharmacokinetics of gacyclidine enantiomers, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, were studied in plasma and spinal cord extracellular fluid (ECF) after experimental spinal cord injury in rats. Spinal cord trauma was produced by introducing an inflatable balloon in the dorsal subdural space. Up...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hoizey G,Kaltenbach ML,Dukic S,Lamiable D,Lallemand A,Millart H,D'Arbigny P,Vistelle R

    更新日期:2001-01-01 00:00:00

  • Drug efflux transport properties of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester (BCECF-AM) and its fluorescent free acid, BCECF.

    abstract::2',7'-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) is a fluorescent probe used to examine multidrug resistance-associated protein (MRP) transporter activity in cells. BCECF is introduced into the cell as the nonfluorescent membrane permeable acetoxymethyl ester, BCECF-AM, where it is hydrolyzed to the membrane ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bachmeier CJ,Trickler WJ,Miller DW

    更新日期:2004-04-01 00:00:00

  • Temperature-dependent effect of edetate disodium on neomycin stability.

    abstract::When heated at temperatures in excess of 100 degrees, the stability of neomycin in aqueous ophthalmic formulations was improved by the addition of edetate disodium (0.01%). As the exposure temperature was reduced, the degree of stability enhancement diminished until the effect was reversed, and addition of edetate dis...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hodges NA,Walton PG

    更新日期:1981-08-01 00:00:00