Decomposition of alpha-hydroxyaryl ketones and characterization of some unusual products.

Abstract:

:Alpha-Hydroxyaryl ketones such as 2-hydroxypropiophenone and 1-(2,4-difluorophenyl)-2-hydroxy-1-propanone, the key intermediates in the preparation of antifungal agents, decompose into oxidized, rearranged, and condensed products. These products were isolated and characterized. The possible mechanisms for the formation of the products are discussed.

journal_name

J Pharm Sci

authors

Gala D,Puar MS,Das PR,Kugelman M,DiBenedetto DJ

doi

10.1002/jps.2600811215

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

1199-203

issue

12

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)49014-8

journal_volume

81

pub_type

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