Multivariate parameter evaluation of pharmaceutically important cellulose ethers.

Abstract:

:A set of nonionic cellulose ethers with varying hydrophobicity and molecular weight has been investigated by principal component analysis (PCA). Several experimental variables such as dynamic surface tension, diffusion coefficient, microviscosity as monitored by a fluorescence probe technique, and intrinsic viscosity are included in the analysis. The experimental variables and observations (polymer fractions) are analyzed in models with good predictive capacities. The apparent equilibrium surface tension correlates to the cloud point and to the critical aggregation concentration in the presence of surfactant. The microviscosity is shown to be a predictive parameter for the degree of hydrophobic substitution. The irreversible process of dynamic surface tension is dependent on the diffusion coefficient but to an even larger degree on the polymer concentration, which is well illustrated by the PCA models.

journal_name

J Pharm Sci

authors

Persson B,Evertsson H,Bergman R,Sundelöf LO

doi

10.1021/js9804922

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

767-74

issue

8

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)50841-1

journal_volume

88

pub_type

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