Multivariate parameter evaluation of pharmaceutically important cellulose ethers.


:A set of nonionic cellulose ethers with varying hydrophobicity and molecular weight has been investigated by principal component analysis (PCA). Several experimental variables such as dynamic surface tension, diffusion coefficient, microviscosity as monitored by a fluorescence probe technique, and intrinsic viscosity are included in the analysis. The experimental variables and observations (polymer fractions) are analyzed in models with good predictive capacities. The apparent equilibrium surface tension correlates to the cloud point and to the critical aggregation concentration in the presence of surfactant. The microviscosity is shown to be a predictive parameter for the degree of hydrophobic substitution. The irreversible process of dynamic surface tension is dependent on the diffusion coefficient but to an even larger degree on the polymer concentration, which is well illustrated by the PCA models.


J Pharm Sci


Persson B,Evertsson H,Bergman R,Sundelöf LO




Has Abstract


1999-08-01 00:00:00














  • Role of benzyl alcohol in the unfolding and aggregation of interferon α-2a.

    abstract::Benzyl alcohol (BA) is the most widely used antimicrobial preservative in multidose protein formulations, and has been shown to cause protein aggregation. Our previous work on a model protein cytochrome c demonstrated that this phenomenon occurs via partial unfolding. Here, we examine the validity of these results by ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bis RL,Singh SM,Cabello-Villegas J,Mallela KM

    更新日期:2015-02-01 00:00:00

  • Application of a Best Practice Approach Using Resonant Mass Measurement for Biotherapeutic Product Characterization.

    abstract::Characterizing and quantifying subvisible particles in protein drug products is critical to ensuring product quality. A variety of analytical methods are used to detect and make meaningful measurements of subvisible particles. Resonant mass measurement (RMM) is a novel technology that characterizes the subvisible part...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Krueger AB,Hadley J,Cheney PP,Markova N,Carpenter JF,Fradkin AH

    更新日期:2019-05-01 00:00:00

  • Determination of segregation tendency of granules using surface imaging.

    abstract::In this study, powder surface imaging was utilized in evaluation of particle size-related segregation behavior of granules during vibration and tableting processes. Altogether, eight granule batches were manufactured using a fluidized bed granulator. The particle size distribution of each batch was measured with sieve...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lakio S,Hatara J,Tervakangas H,Sandler N

    更新日期:2012-06-01 00:00:00

  • Comparative pharmacokinetics of butylated hydroxyanisole and butylated hydroxytoluene in rabbits.

    abstract::The widespread use of butylated hydroxyanisole (I) and butylated hydroxytoluene (II) as food antioxidants recently has been criticized by the Food and Drug Administration because of their pharmacological and toxicological effects. Interest also has arisen recently in the use of these compounds as anticancer agents. Th...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: El-Rashidy R,Niazi S

    更新日期:1980-12-01 00:00:00

  • Cholesterol-mediated activation of P-glycoprotein: distinct effects on basal and drug-induced ATPase activities.

    abstract::Cholesterol promotes basal and verapamil-induced ATPase activity of P-glycoprotein (P-gp). We investigated whether these effects are related to each other and to the impact of the sterol on bilayer fluidity and verapamil membrane affinity. P-gp was reconstituted in egg-phosphatidylcholine (PhC) liposomes with or witho...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Belli S,Elsener PM,Wunderli-Allenspach H,Krämer SD

    更新日期:2009-05-01 00:00:00

  • Protein adsorption, desorption, and aggregation mediated by solid-liquid interfaces.

    abstract::Adsorption of proteins to solid-fluid interfaces is often empirically found to promote formation of soluble aggregates and larger, subvisible, and visible particles, but key stages in this process are often difficult to probe directly. Aggregation mediated by adsorption to water-silicon oxide (SiOx) interfaces, akin t...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Perevozchikova T,Nanda H,Nesta DP,Roberts CJ

    更新日期:2015-06-01 00:00:00

  • Distribution of gacyclidine enantiomers after experimental spinal cord injury in rats: possible involvement of an active transport system.

    abstract::The pharmacokinetics of gacyclidine enantiomers, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, were studied in plasma and spinal cord extracellular fluid (ECF) after experimental spinal cord injury in rats. Spinal cord trauma was produced by introducing an inflatable balloon in the dorsal subdural space. Up...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hoizey G,Kaltenbach ML,Dukic S,Lamiable D,Lallemand A,Millart H,D'Arbigny P,Vistelle R

    更新日期:2001-01-01 00:00:00

  • Mechanism of action of retinyl compounds on wound healing IV: effect of desmethylretinoic acid and its vinylogs on granuloma formation.

    abstract::The effect of side-chain length of desmethylretinoic acid on granuloma formation induced by implantation of cotton pellets was studied. As in the homologous series of retinoic acid studies, compounds with side chains shorter than retinoic acid were not active while compounds with side chains as long or longer than ret...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lee KH,Fu CC,Jung M

    更新日期:1976-04-01 00:00:00

  • Serum lipid-lowering properties of 6-chloro-9-[2-(6-methyl-3-pyridyl)ethyl]-1,2,3,4-tetrahydrocarbazole-2-carboxylic acid.

    abstract::6-Chloro-9-[2-(6-methyl-3-pyridyl)ethyl]-1,2,3,4-tetrahydrocarbazole-2-carboxylic acid hydrochloride lowered serum cholesterol, triglyceride, phospholipid, and free fatty acid levels in normal rats. The compound appeared to have a low toxicity and to be well tolerated in mice, adult and neonatal rats, and rabbits. At ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Dalton C,Pool WR

    更新日期:1977-03-01 00:00:00

  • Systematic study on the chemical stability of the prodrug antitumor agent carzelesin (U-80,244)

    abstract::The chemical stability of the novel anticancer agent carzelesin in aqueous buffer/acetonitrile (1:1, v/v) mixtures has been investigated utilizing a stability-indicating reversed-phase high-performance liquid chromatographic assay. The degradation kinetics of carzelesin has been studied as a function of pH, buffer com...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Vries JD,Doppenberg WG,Henrar RE,Bult A,Beijnen JH

    更新日期:1996-11-01 00:00:00

  • General linearized biexponential model for QSAR data showing bilinear-type distribution.

    abstract::A major impediment of many QSAR-type analyses is that the data show a maximum or minimum and can no longer be adequately described by linear functions that provide unrivaled simplicity and usually give good description over more restricted ranges. Here, a general linearized biexponential (LinBiExp) model is proposed t...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Buchwald P

    更新日期:2005-11-01 00:00:00

  • Cyclazocine and norepinephrine uptake, metabolism, and turnover in the rat brain.

    abstract::The effects of cyclazocine, a narcotic agonist/antagonist, on the uptake, metabolism, and turnover of norepinephrine in rat brains were studied. Cyclazocine significantly depressed the accumulation of intracisternally administered [3H]norepinephrine and the formation of 3,4-[3H]dihydroxymandelic acid but did not alter...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Russi GD

    更新日期:1985-01-01 00:00:00

  • Temperature Measurement by Sublimation Rate as a Process Analytical Technology Tool in Lyophilization.

    abstract::Product temperature (Tb) and drying time constitute critical material attributes and process parameters in the lyophilization process and especially during the primary drying stage. In the study, we performed a temperature measurement by the sublimation rate (TMbySR) to monitor the Tb value and determine the end point...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kawasaki H,Shimanouchi T,Sawada H,Hosomi H,Hamabe Y,Kimura Y

    更新日期:2019-07-01 00:00:00

  • A novel inhalable form of rifapentine.

    abstract::Recent murine studies found that rifapentine, dosed daily, at least halved tuberculosis treatment times compared with standard rifampicin and isoniazid-containing regimens. However, in humans, an inhalable form of rifapentine may be necessary to considerably shorten treatment duration because of the physiological barr...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chan JG,Duke CC,Ong HX,Chan JC,Tyne AS,Chan HK,Britton WJ,Young PM,Traini D

    更新日期:2014-05-01 00:00:00

  • Myocardial effect compartment modeling of metoprolol and sotalol: importance of myocardial subsite drug concentration.

    abstract::We have recently reported the time course of acute myocardial drug uptake and simultaneous pharmacodynamic effects for metoprolol (4 mg; n = 12) and sotalol (20 mg; n = 10) in patients with ischemic heart disease. The acute pharmacodynamic effects of the two drugs included reductions in both spontaneous heart rate and...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 临床试验,杂志文章


    authors: Ritchie RH,Morgan DJ,Horowitz JD

    更新日期:1998-02-01 00:00:00

  • Extended least squares (ELS) for pharmacokinetic models.

    abstract::An important part of pharmacokinetic research is fitting models to observed data and estimating the parameters in the model. In general, parameter estimation in pharmacokinetics is a subset of the general problem of nonlinear regression or parameter estimation in nonlinear regression models. The same criteria, algorit...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Metzler CM

    更新日期:1987-07-01 00:00:00

  • Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function.

    abstract::The purpose of this study was to examine the effects of extracts and flavone derivatives from the rhizome of Kaempferia parviflora on P-glycoprotein (P-gp)-mediated transport in LLC-GA5-COL150, a transfectant cell line of a porcine kidney epithelial cell line LLC-PK1 with human MDR1 cDNA. Ethanol extract obtained from...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Patanasethanont D,Nagai J,Yumoto R,Murakami T,Sutthanut K,Sripanidkulchai BO,Yenjai C,Takano M

    更新日期:2007-01-01 00:00:00

  • Degradation of paclitaxel and related compounds in aqueous solutions I: epimerization.

    abstract::Paclitaxel and other taxanes have complex structures including the presence of numerous hydrolytically sensitive ester groups and a chiral center that readily undergoes epimerization thus making their kinetics complex. The present study attempts to understand the mechanism of epimerization at the 7-position of paclita...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tian J,Stella VJ

    更新日期:2008-03-01 00:00:00

  • Synthesis and biological evaluation of p-bromospiperone as potential neuroleptic drug.

    abstract::p-Bromospiperone was prepared from the reaction of spiperone with bromine. It was tested for dopamine receptor binding affinity in vitro and its ability to stimulate prolactin secretion in vivo. The results indicate no significant change of biological activities due to the bromination of spiperone. ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Huang CC,Friedman AM,So R,Simonovic M,Meltzer HY

    更新日期:1980-08-01 00:00:00

  • Drug compatibility with the sponge phases formed in monoolein, water, and propylene glycol or poly(ethylene glycol).

    abstract::The liquid sponge phase, a bicontinuous lipid-water system, formed in solvent-monoolein-water systems was investigated with respect to drug compatibility. The solvents propylene glycol and poly(ethylene glycol) swell the bicontinuous cubic phase of the monoolein-water system and form the sponge phase at constant water...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Alfons K,Engstrom S

    更新日期:1998-12-01 00:00:00

  • Implementation of an ADME enabling selection and visualization tool for drug discovery.

    abstract::The pharmaceutical industry has large investments in compound library enrichment, high throughput biological screening, and biopharmaceutical (ADME) screening. As the number of compounds submitted for in vitro ADME screens increases, data analysis, interpretation, and reporting will become rate limiting in providing A...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Stoner CL,Gifford E,Stankovic C,Lepsy CS,Brodfuehrer J,Prasad JV,Surendran N

    更新日期:2004-05-01 00:00:00

  • Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection.

    abstract::The insidious nature of Zika virus (ZIKV) infections can have a devastating consequence for fetal development. Recent reports have highlighted that chloroquine (CQ) is capable of inhibiting ZIKV endocytosis in brain cells. We applied pharmacokinetic modeling to develop a predictive model for CQ exposure to identify an...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Olafuyi O,Badhan RKS

    更新日期:2019-01-01 00:00:00

  • Freeze drying of L-arginine/sucrose-based protein formulations, part I: influence of formulation and arginine counter ion on the critical formulation temperature, product performance and protein stability.

    abstract::The objective of this study was to investigate product performance of freeze dried l-arginine/sucrose-based formulations under variation of excipient weight ratios, l-arginine counter ions and formulation pH as a matrix to stabilize a therapeutic monoclonal antibody (MAb) during freeze drying and shelf life. Protein a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Stärtzel P,Gieseler H,Gieseler M,Abdul-Fattah AM,Adler M,Mahler HC,Goldbach P

    更新日期:2015-07-01 00:00:00

  • Colloidal and thermal characteristics of concentrated dispersions of polymethacrylate-based latices for aqueous enteric coating.

    abstract::We have used rheological and thermal methods to study the colloidal characteristics of a widely used technical latex. The dispersions of poly(methacrylic acid-ethyl acrylate) (Eudragit L100-55) were found to be stabilized by a combination of electrostatic and steric mechanisms termed as electrosteric stabilization. Th...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Paulsson M,Singh SK

    更新日期:1999-04-01 00:00:00

  • The use of N,N-diethyl-m-toluamide to enhance dermal and transdermal delivery of drugs.

    abstract::A dermal penetration enhancer has been found which improves the dermal delivery of a wide variety of drugs and at the same time has a history of low toxicity for human dermal application. N,N-Diethyl-m-toluamide (I) has been shown to improve the delivery of many drugs through hairless mouse skin in an in vitro diffusi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Windheuser JJ,Haslam JL,Caldwell L,Shaffer RD

    更新日期:1982-11-01 00:00:00

  • Polynitro aromatic compounds in analytical chemistry II: Reaction of menadione with 2,4-dinitrophenylhydrazine.

    abstract::The intense blue color formed in the official assay of menadione injection by treatment of the sample with 2,4-dinitrophenylhydrazine and ammonia is shown by data from visible light spectra and mass spectra and by comparison of the pKa value with that of the corresponding reaction product of acetone to be due to proto...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Burns LB,Stedman RJ,Tuckerman MM

    更新日期:1978-02-01 00:00:00

  • Nanoscale surface characterization and miscibility study of a spray-dried injectable polymeric matrix consisting of poly(lactic-co-glycolic acid) and polyvinylpyrrolidone.

    abstract::Injectable controlled-release formulations are of increasing interest for the treatment of chronic diseases. This study aims to develop and characterize a polymeric matrix for intramuscular or subcutaneous injection, consisting of two biocompatible polymers, particularly suitable for formulating poorly soluble drugs. ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Meeus J,Chen X,Scurr DJ,Ciarnelli V,Amssoms K,Roberts CJ,Davies MC,van Den Mooter G

    更新日期:2012-09-01 00:00:00

  • Antiradiation compounds XV: condensations of carbon disulfide with amino, chloro, cyanomethyl, and sulfonamido heterocycles.

    abstract::Condensations of carbon disulfide were carried out with amino, chloro, and diamino heterocycles to give condensed ring thiazoline-2-thiones and imidazoline-2-thiones, with cyanomethyl heterocycles to give dithio acid derivatives, and with heterocyclic sulfonamides to give sulfonyldithiocarbamates. Of several examples ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Foye WO,Kauffman JM,Lanzillo JJ,LaSala EF

    更新日期:1975-08-01 00:00:00

  • Interaction of anionic compounds with gelatin. I: Binding studies.

    abstract::Even though gelatin is the most widely used polymeric excipient in pharmaceutical products, scant attention has been paid to its interaction with small organic molecules. The present work deals with the interaction of gelatin and four monosulfonated or monocarboxylated azo dyes having hydrocarbon moieties of different...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Gautam J,Schott H

    更新日期:1994-07-01 00:00:00

  • Enhancing effects of lipophilic vehicles on skin penetration of methyl nicotinate in vivo.

    abstract::Vehicle effects may be caused by thermodynamic effects and by specific (penetration enhancing) effects. To investigate the effects of various lipophilic vehicles on drug penetration, an in vivo permeability study was conducted with methyl nicotinate as the model drug. The drug was dissolved in the respective vehicles ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 临床试验,杂志文章


    authors: Leopold CS,Lippold BC

    更新日期:1995-02-01 00:00:00