Abstract:
:Magnetic resonance imaging (MRI) with chemical shift resolution is a recent extension of MRI and it provides information about species resolved molecular transport on the macroscopic scale in complex systems. In this contribution, we show that by using this novel method, one can predict the behavior of drug and food molecules when they are in contact with the mucosal layer in the gastrointestinal tract. For the first time, the transport properties of a mixture of nutrients (i.e., a solution of ethanol and glucose) and of a model drug carrier (i.e., an equimolar solution of cationic and nonionic surfactants) through a mucin gel have been investigated. This study shows that transport properties of the diffusing molecules through a mucin gel are dependent on their size and physicochemical properties. In addition, we show that mucin gel acts as an efficient selective barrier. It favors the disintegration of mixed micelles of nonionic and cationic surfactants by stopping the diffusion of cationic surfactants with slightly affecting the diffusion of the nonionic surfactants.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Lafitte G,Thuresson K,Söderman Odoi
10.1002/jps.20749subject
Has Abstractpub_date
2007-02-01 00:00:00pages
258-63issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(16)32187-6journal_volume
96pub_type
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