Abstract:
:A kinetic dialysis technique together with a radiolabeled chenodeoxycholate (CDC) was used to determine the existence of a relationship between the monomer concentration of CDC and the total CDC concentration in different CDC solutions containing 1 or 5 mM sulfobutylether (SBE)-β-cyclodextrin. On the basis of the nature of the relationship and a binding model with binding constants of K₁ and K₂, the binding affinity for the solutions was quantified at the best curve fitting using a least-squares technique. The very high binding affinity of K₁ and the very low (i.e., negligible) binding affinity of K₂ indicate the formation of 1:1 inclusion complexes. In addition, the values of K₁ and K₂ were reasonably interpreted. Similar analysis showed that the formation of 1:2 inclusion complexes and the self-association of the SBE-β-cyclodextrin molecules in the solutions are unlikely. The present study provides a basis for investigating the self-association, quantifying the binding affinity, and interpreting the quantified values.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Liu CL,Chang CL,Jhou SY,Higuchi WIdoi
10.1002/jps.23231subject
Has Abstractpub_date
2012-08-01 00:00:00pages
2883-90issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(15)31506-9journal_volume
101pub_type
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