Abstract:
:Results of studies carried out in rats for model compounds, D-(-) mandelic acid, benzoylformic acid, and some of their para-alkylated homologs, showed that their biological half-lives determined from the elimination phase of urinary excretion data were longer than those determined from the elimination phase of blood level data. With compounds that followed multicompartment open models, the initial distributive phase (alpha-phase) noted from the blood level data was not detected from the urinary excretion data. Based on the analysis of half-life data obtained in the absence and presence of DL-tropic acid (a competitive renal tubular secretion inhibitor of these compounds), it is proposed that, besides the shortness of the alpha-phase period, the factor accounting for these compounds is their retention and/or detention in the renal tubular membranes during their tubular secretion. Furthermore, it is proposed that the renal tubular membranes do not constitute a part of the central or peripheral compartment. Examples are cited to show that, where studies are reported for the same drugs in the same human subjects in the same laboratory, drugs usually exhibit longer biological half-lives when urinary excretion data rather than blood level data are used.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Amin YM,Nagwekar JBdoi
10.1002/jps.2600650920subject
Has Abstractpub_date
1976-09-01 00:00:00pages
1341-5issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(15)40947-5journal_volume
65pub_type
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journal_title:Journal of pharmaceutical sciences
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journal_title:Journal of pharmaceutical sciences
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更新日期:2007-08-01 00:00:00
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journal_title:Journal of pharmaceutical sciences
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更新日期:2019-01-01 00:00:00
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journal_title:Journal of pharmaceutical sciences
pub_type: 杂志文章
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journal_title:Journal of pharmaceutical sciences
pub_type: 杂志文章
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