Abstract:
:A method for the determination of sematilide levels in human plasma is described. After the addition of an internal standard, plasma samples are adjusted to pH 8.5 and extracted with a solution of 7.5% isopropanol in methylene chloride. Separation from co-extracted matrix constituents is performed by reversed-phase HPLC followed by UV detection at 254 nm. The assay is linear in the concentration range 12-2400 ng/mL when 0.5-mL aliquots of plasma are extracted. Application of the method to the analysis of samples obtained from eight healthy volunteers given an oral dose of 100 mg of sematilide hydrochloride is shown.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Dancik S,Koziol T,Nisperos E,Woolf Edoi
10.1002/jps.2600800214subject
Has Abstractpub_date
1991-02-01 00:00:00pages
157-9issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(15)48455-2journal_volume
80pub_type
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