Abstract:
:Stent implantation following angioplasty is the standard treatment of coronary artery disease necessitating interventional procedures. The use of stents as a platform for local drug delivery is a popular strategy to achieve local pharmacological treatment to the diseased artery. Drug eluting stents (DES) are now largely preferred to bare metal stents when stent implantation is necessary. Lately, there have been several reports questioning the long-term safety of DES. An alternative to these drug eluting metal stents are bioresorbable polymeric stents (BPS) because of the many advantages of bioresorbable material. However, the fundamental differences in polymeric and metallic materials make the development of such an alternative a significant challenge. This review discusses the different advantages of BPS and the many constrains and requirements of such devices. An up to date commented review of published data concerning BPS is presented. Considerations are given on using BPS as local drug delivery systems as well as on evaluating BPS performances.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Sharkawi T,Cornhill F,Lafont A,Sabaria P,Vert Mdoi
10.1002/jps.20957subject
Has Abstractpub_date
2007-11-01 00:00:00pages
2829-37issue
11eissn
0022-3549issn
1520-6017pii
S0022-3549(16)32399-1journal_volume
96pub_type
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