Abstract:
:A rapid, simple, and accurate high-performance liquid chromatographic procedure using an amino-bonded microparticulate column is reported for the determination of chlorpromazine hydrochloride (I) and its two oxidation products, the sulfoxide (II) and the sulfone (III), in commercially available pharmaceutical dosage preparations. Simultaneous identification and quantitation of II and III in the presence of at least 100 times the amount of parent compound were achieved with selective fluorometric detection. Identification and quantitation of I were achieved by changing the fluorescence detection mode. A typical chromatographic run was completed within 15 min. The described procedure is simpler, more sensitive, and more accurate than the USP XIX methods, particularly for the analysis of II in injectables. Quantitation of II and III at levels as low as 0.1 microgram, representing 0.1% contamination, was demonstrated.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Takahashi DMdoi
10.1002/jps.2600690217subject
Has Abstractpub_date
1980-02-01 00:00:00pages
184-7issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(15)43048-5journal_volume
69pub_type
杂志文章abstract::In the present work, the effect of controlled nucleation on the stability of human growth hormone (hGH) during freeze-drying has been investigated. More specifically, the vacuum-induced surface freezing technique has been compared to conventional freezing, both with and without an annealing step. Size exclusion chroma...
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