Compartment model to describe peripheral arterial-venous drug concentration gradients with drug elimination from the venous sampling compartment.


:The central compartment of an n-compartment mammillary model was concatenated with a gradient compartment (i.e., venous sampling compartment) and with a conventional effect compartment to model arterial-venous drug concentration gradients and the arterial drug concentration vs effect relationship, respectively. To model drug metabolism during transit between the peripheral arterial and peripheral venous circulations, the gradient compartment included a first-order elimination path. Simulations of the model were employed to demonstrate the impact of sampling site (e.g., arterial vs peripheral venous) on analyses of the concentration vs effect relationship.


J Pharm Sci


Jacobs JR,Nath PA




Has Abstract


1995-03-01 00:00:00














  • A Mechanistic Model for Predicting the Physical Stability of Amorphous Solid Dispersions.

    abstract::In this paper, we establish a mechanistic model for the prediction of amorphous solid dispersion (ASD) stability. The novel approach incorporates fundamental physical parameters, principally supersaturation, diffusivity, and interfacial energy, to model crystallization in ASDs accounting for both kinetic and thermodyn...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ojo AT,Lee PI

    更新日期:2020-08-18 00:00:00

  • Development of a Stable Liquid Formulation for Live Attenuated Influenza Vaccine.

    abstract::Live attenuated influenza vaccine (LAIV) is considered one of the most effective vaccines and can be manufactured quickly and inexpensively to counter seasonal or pandemic influenza. Lyophilization is widely used in vaccine production. However, it requires a longer production cycle and large-scale equipment, thus posi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sun Y,Shen Z,Zhang C,Yi Y,Zhu K,Xu F,Kong W

    更新日期:2019-07-01 00:00:00

  • Determination of pindolol in biological fluids by electron-capture GLC.

    abstract::An electron-capture GLC method was developed for measuring pindolol in human plasma and urine. The unchanged drug was extracted with benzene from alkalinized plasma or urine using propranolol as the internal standard. Both compounds subsequently were back-extracted into 0.1 M HCl and then into benzene. After evaporati...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Guerret M,Lavene D,Kiechel JR

    更新日期:1980-10-01 00:00:00

  • Relative and absolute bioavailability of cibenzoline capsules and tablets in healthy subjects.

    abstract::Eighteen healthy adult volunteers completed an open-label, four-way crossover study designed to determine the bioequivalency of 160-mg cibenzoline [2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole] capsules and tablets, their relative bioavailability compared with an oral solution of the drug, as well as the absol...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Massarella J,Silvestri T,Lin A

    更新日期:1986-09-01 00:00:00

  • Solvent effects on chemical processes. I: Solubility of aromatic and heterocyclic compounds in binary aqueous-organic solvents.

    abstract::The standard free energy change (delta G0) for equilibrium dissolution in binary solvent mixtures is written as a sum of effects arising from solvent-solvent interactions (the general medium effect), solvent-solute interactions (the solvation effect), and solute-solute interactions (the intersolute effect). The genera...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Khossravi D,Connors KA

    更新日期:1992-04-01 00:00:00

  • Acid decomposition of omeprazole in the absence of thiol: a differential pulse polarographic study at the static mercury drop electrode (SMDE).

    abstract::The reactions of omeprazole, a potent proton pump inhibitor (PPI), were investigated in the absence of a nucleophile. Reactions were monitored, using differential pulse polarography (DPP) at the static mercury drop electrode (SMDE), in solutions buffered to pH values ranging from 2.0 to 8.0. The fast, sensitive, and s...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Qaisi AM,Tutunji MF,Tutunji LF

    更新日期:2006-02-01 00:00:00

  • Uniform encapsulation of stable protein nanoparticles produced by spray freezing for the reduction of burst release.

    abstract::Stable protein nanostructured particles, produced by spray freezing into liquid (SFL) nitrogen, were encapsulated uniformly into microspheres to reduce the burst release over the first 24 h. The denaturation and aggregation of these bovine serum albumin (BSA) high-surface area particles were minimal due to ultra-rapid...

    journal_title:Journal of pharmaceutical sciences

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    authors: Leach WT,Simpson DT,Val TN,Anuta EC,Yu Z,Williams RO 3rd,Johnston KP

    更新日期:2005-01-01 00:00:00

  • VLDL-resembling phospholipid-submicron emulsion for cholesterol-based drug targeting.

    abstract::The objective of the current study was to develop and evaluate VLDL-resembling phospholipid-submicron emulsion (PSME) as a carrier system for new cholesterol-based compounds for targeted delivery to cancer cells. BCH, a boronated cholesterol compound, was originally developed in our laboratory to mimic the cholesterol...

    journal_title:Journal of pharmaceutical sciences

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    authors: Shawer M,Greenspan P,ØIe S,Lu DR

    更新日期:2002-06-01 00:00:00

  • Drug delivery trends in clinical trials and translational medicine: evaluation of pharmacokinetic properties in special populations.

    abstract::In spite of the recent advances in technology to optimize the absorption, distribution, metabolism and elimination (ADME) properties of new and promising medicinal products to reduce clinical failures, the investigation of drug disposition in the pediatric and elderly populations continues to be under evaluated. With ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Chien JY,Ho RJ

    更新日期:2011-01-01 00:00:00

  • Separation, identification, and quantitation of anthralin and its decomposition products.

    abstract::Anthralin and its decomposition products were separated by both column chromatographic and TLC techniques. Two decomposition products were characterized by TLC, melting-point data, and UV and IR spectroscopy. Pure anthralin and its decomposition products also were determined quantitatively. ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Elsabbagh HM,Whitworth CW,Schramm LC

    更新日期:1979-03-01 00:00:00

  • Modified silicone elastomer vaginal gels for sustained release of antiretroviral HIV microbicides.

    abstract::We previously reported nonaqueous silicone elastomer gels (SEGs) for sustained vaginal administration of the CCR5-targeted entry inhibitor maraviroc (MVC). Here, we describe chemically modified SEGs (h-SEGs) in which the hydrophobic cyclomethicone component was partially replaced with relatively hydrophilic silanol-te...

    journal_title:Journal of pharmaceutical sciences

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    authors: Forbes CJ,McCoy CF,Murphy DJ,Woolfson AD,Moore JP,Evans A,Shattock RJ,Malcolm RK

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  • Effect of lipophilicity on the bioavailability of drugs after percutaneous administration by dissolving microneedles.

    abstract::To elucidate drug lipophilicity effects on the bioavailability (BA) of drugs from skin after administration by dissolving microneedles, nine compounds with different lipophilicity indexes (log p value) were formulated into two-layered dissolving microneedles and administered percutaneously to rat skin: desmopressin (D...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ito Y,Yoshimura M,Tanaka T,Takada K

    更新日期:2012-03-01 00:00:00

  • Antitumor agents LVI: the protein synthesis inhibition by genkwadaphnin and yuanhuacine of P-388 lymphocytic leukemia cells.

    abstract::Two natural products isolated from the plant Daphne genkwa have been shown to possess antileukemic activity in mice. Genkwadaphnin and yuanhuacine were observed to inhibit DNA and protein synthesis in P-388 leukemic cells. A detailed study of the effects of these two diterpene esters on protein synthesis of leukemic c...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Liou YF,Hall IH,Lee KH

    更新日期:1982-12-01 00:00:00

  • Liposomes as carriers for topical and transdermal delivery.

    abstract::The delivery of active agents to the skin by liposome carriers is an interdisciplinary topic of great interest today. Data accumulated over the last decade strongly point to important advantages of these drug delivery systems. A symposium devoted to classic and new approaches in the use of liposomal systems was organi...

    journal_title:Journal of pharmaceutical sciences



    authors: Touitou E,Junginger HE,Weiner ND,Nagai T,Mezei M

    更新日期:1994-09-01 00:00:00

  • Interaction of nitroglycerin with human blood components.

    abstract::Nitroglycerin is rapidly lost from solution when incubated with red blood cells or whole blood. The assumption that the loss is enzymatic in nature may not be true, since no major metabolite is detected during this incubation. Explanation on the basis of a chemical reaction is also difficult, since the products of the...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sokoloski TD,Wu CC,Wu LS,Burkman AM

    更新日期:1983-04-01 00:00:00

  • GLC determination of procainamide in biological fluids.

    abstract::A GLC method for the determination of procainamide in biological fluids is presented. By using a dipropyl analog of procainamide as an internal standard, both compounds can be chromatographed directly, yielding linear calibration curves and a sensitivity that allows quantitative determination of concentrations as low ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Simons KJ,Levy RH

    更新日期:1975-12-01 00:00:00

  • Optical crystallographic characteristics of some USP drugs.

    abstract::Optical crystallographic data were determined on a variety of newer USP drugs for which data had not been previously obtained. The ingredients in an unknown sample can be identified by polarized light microscopy by mounting small amounts of the material in successive specific refractive index liquids and determining r...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Jordan DD

    更新日期:1993-12-01 00:00:00

  • Trace decomposition of selegiline. Use of worst-case kinetics for a stable drug.

    abstract::A solution of selegiline hydrochloride reference standard, which contained no detectable impurities at the time of its preparation, was found by HPLC to contain a trace of a compound at the locus of methamphetamine when analyzed after 1 year. Heating selegiline solutions at pH 7 and 105 degrees C produced methamphetam...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chafetz L,Desai MP,Sukonik L

    更新日期:1994-09-01 00:00:00

  • Quantitative TLC determination of propranolol in human plasma.

    abstract::A spectrodensitometric assay was developed for propranolol based on measurement of the absorbance of the drug on silica gel plates irradiated at 822 nm. Quantities as low as 0.10 microgram can be detected, and a linear relationship was obtained between 0.010 and 0.400 microgram. The percent recovery from plasma spiked...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hadzija BW,Mattocks AM

    更新日期:1978-09-01 00:00:00

  • Determination of a quaternary mixture of vitamins B6, B1, and B12 and uridine 5'-triphosphate, by derivative spectrophotometry.

    abstract::A new method for determining a quaternary mixture of vitamins B6, B1, and B12 and uridine 5'-triphosphate (UPT) using second-derivative spectrophotometry is described. Calibration graphs were linear up to 30 micrograms/mL of vitamin B6 at 307 nm (r = 0.9999) and vitamin B1 at 282.7 nm (r = 0.9997) and up to 35 microgr...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Morelli B

    更新日期:1995-01-01 00:00:00

  • Another model for giving.

    abstract::Most of the global healthcare issues facing us--from expanding access to care, to providing medical and dental care in the aftermath of disasters--are far too complex for any single sector to successfully solve. Industry, the healthcare profession, government, academia and non-governmental organizations (NGOs) are all...

    journal_title:Journal of pharmaceutical sciences

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    authors: Bergman SM

    更新日期:2008-12-01 00:00:00

  • Interactions of cephalosporins and penicillins with nonpolar octadecylsilyl stationary phase.

    abstract::The capacity factors of several penicillins and cephalosporins, as well as those of 7-aminocephalosporanic acid, 6-aminopenicillanic acid, and 7-aminodeacetoxycephalosporanic acid, were determined at pH 2.5-7.5 with different methanol concentrations in the mobile phase. The influence of ionic strength on activity fact...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Salto F,Prieto JG,Alemany MT

    更新日期:1980-05-01 00:00:00

  • Synthesis, cytotoxicity, hypolipidemic and anti-inflammatory activities of amine-boranes and esters of boron analogues of choline and thiocholine.

    abstract::Boron analogues of carbamoylcholine and thiocholine and esters of these analogues were prepared. These compounds were fairly stable toward hydrolysis and demonstrated moderate anti-inflammatory and hypolipidemic activities in mice. The hypolipidemic activity of the compounds at a dose of 8 mg/kg/day was equivalent in ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sood A,Sood CK,Spielvogel BF,Hall IH,Wong OT

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  • A linear theory of transdermal transport phenomena.

    abstract::A theory of charge, fluid-mass, and solute (including macromolecular) transport through porous media is applied to describe transport phenomena across the external layer of mammalian skin. Linear relationships are derived between transport fluxes and applied fields. These relationships introduce six effective transder...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Edwards DA,Langer R

    更新日期:1994-09-01 00:00:00

  • General linearized biexponential model for QSAR data showing bilinear-type distribution.

    abstract::A major impediment of many QSAR-type analyses is that the data show a maximum or minimum and can no longer be adequately described by linear functions that provide unrivaled simplicity and usually give good description over more restricted ranges. Here, a general linearized biexponential (LinBiExp) model is proposed t...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Buchwald P

    更新日期:2005-11-01 00:00:00

  • Biowaiver approach for biopharmaceutics classification system class 3 compound metformin hydrochloride using in silico modeling.

    abstract::The dependency of metformin in vivo disposition on the rate and extent of dissolution was studied. The analysis includes the use of fundamental principles of drug input, permeability, and intestinal transit time within the framework of a compartmental absorption transit model to predict key pharmacokinetic (PK) parame...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Crison JR,Timmins P,Keung A,Upreti VV,Boulton DW,Scheer BJ

    更新日期:2012-05-01 00:00:00

  • Determination of water-soluble acid distribution in poly(lactide-co-glycolide).

    abstract::Determination of the kinetics of water-soluble degradation products inside poly(lactide-co-glycolide) (PLGA) delivery systems during polymer degradation is important to evaluate the polymer microclimate conditions, particularly microclimate pH changes for optimization of encapsulated drug stability. A pre-derivatizati...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ding AG,Schwendeman SP

    更新日期:2004-02-01 00:00:00

  • Quantitative determinations of two decongestants and an antihistamine in combination using paired ion high-pressure liquid chromatography.

    abstract::A single method for the quantitative determinations of three active ingredients, phenylephrine hydrochloride, phenylpropanolamine hydrochloride, and brompheniramine maleate, and one inactive ingredient (sodium benzoate) in a commercial product for colds is reported. The method is based on paired ion high-pressure liqu...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ghanekar AG,Das Gupta V

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  • GLC determination of methenamine in tablets.

    abstract::A rapid and sensitive GLC method was developed for the quantitative determination of methenamine in tablets. The method was shown to possess several advantages over the official NF assay. After dissolution of the whole tablet in absolute ethanol and addition of an internal standard (pentylenetetrazol), an aliquot was ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Strom JG Jr,Jun HW

    更新日期:1977-04-01 00:00:00

  • Degradation kinetics and isomerization of cefdinir, a new oral cephalosporin, in aqueous solution. 1.

    abstract::Hydrolytic degradation products of cefdinir were studied in acidic (pH 1), neutral (pH 6), and basic (pH 9) solutions. Seven major degradation products were isolated by preparative and/or high-performance liquid chromatography and characterized by UV, IR, 1H-NMR, and mass spectra. To clarify degradation pathways in ea...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Okamoto Y,Kiriyama K,Namiki Y,Matsushita J,Fujioka M,Yasuda T

    更新日期:1996-09-01 00:00:00