Abstract:
:The synthesis, local anesthetic and antiarrhythmic properties, and CNS toxicity of 14 2-(3-alkylaminoalkylamido)-pyrroles are described. Most of the compounds exhibited local anesthetic activity by the guinea pig wheal test, with seven showing comparable or greater activity than lidocaine. Most compounds also exhibited antiarrhythmic activity; three compounds had more potent activity than lidocaine. All compounds exhibiting antiarrhythmic activity also were toxic to the CNS. However, two of the three compounds having greater activity than lidocaine possessed more desirable therapeutic indexes.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Sowell JW Sr,Block AJ,Derrick ME,Freeman JJ,Kosh JW,Mubarak PF,Tenthorey PAdoi
10.1002/jps.2600700519subject
Has Abstractpub_date
1981-05-01 00:00:00pages
537-41issue
5eissn
0022-3549issn
1520-6017pii
S0022-3549(15)43695-0journal_volume
70pub_type
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