Abstract:
:Hemoglobin microcapsules were prepared through cross-linking of hemoglobin itself with various acyldichlorides. Variations in the reticulation conditions were preformed in order to ameliorate the oxygen dissociation curve, the mean diameter, and the possibility for the microcapsules to be lyophilized. With terephthaloylchloride, as the cross-linking agent, incorporation of inositol hexaphosphate and glucose, followed by stabilization through glutaraldehyde and using high stirring speed, allowed preparation of stable hemoglobin microcapsules, 5 micrometers in diameter, which suffered rapid lysis by proteases. They were able to ensure oxygen transfer: the dissociation curve was sigmoidal with a p50 = 13 mm Hg. They retained these properties after lyophilization followed by rehydration.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Lévy MC,Rambourg P,Lévy J,Potron Gdoi
10.1002/jps.2600710710subject
Has Abstractpub_date
1982-07-01 00:00:00pages
759-62issue
7eissn
0022-3549issn
1520-6017pii
S0022-3549(15)44242-Xjournal_volume
71pub_type
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