Racemic species of sodium ibuprofen: characterization and polymorphic relationships.

Abstract:

:Racemic and homochiral sodium ibuprofen were characterized by thermal analysis and powder X-ray diffractometry. The melting point phase diagram was constructed and thermodynamic calculation was performed. In contrast to racemic ibuprofen, which is a racemic compound, racemic sodium ibuprofen forms both a racemic conglomerate (termed the gamma-form) as well as two polymorphic racemic compounds, alpha and beta, which are less stable monotropes. From the supercooled liquid, alpha and beta crystallized along with the original gamma-form. Forms alpha and beta are "enantiotropically related" with a transition temperature between 75 degrees and 113 degrees C, but can be considered to be metastable monotropes of the racemic conglomerate, the stable gamma-form.

journal_name

J Pharm Sci

authors

Zhang GG,Paspal SY,Suryanarayanan R,Grant DJ

doi

10.1002/jps.10393

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

1356-66

issue

7

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(16)31285-0

journal_volume

92

pub_type

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