Racemic species of sodium ibuprofen: characterization and polymorphic relationships.


:Racemic and homochiral sodium ibuprofen were characterized by thermal analysis and powder X-ray diffractometry. The melting point phase diagram was constructed and thermodynamic calculation was performed. In contrast to racemic ibuprofen, which is a racemic compound, racemic sodium ibuprofen forms both a racemic conglomerate (termed the gamma-form) as well as two polymorphic racemic compounds, alpha and beta, which are less stable monotropes. From the supercooled liquid, alpha and beta crystallized along with the original gamma-form. Forms alpha and beta are "enantiotropically related" with a transition temperature between 75 degrees and 113 degrees C, but can be considered to be metastable monotropes of the racemic conglomerate, the stable gamma-form.


J Pharm Sci


Zhang GG,Paspal SY,Suryanarayanan R,Grant DJ




Has Abstract


2003-07-01 00:00:00














  • Time-dependent changes in the activation of RhoA/ROCK and ERM/p-ERM in the increased expression of intestinal P-glycoprotein by repeated oral treatment with etoposide.

    abstract::Previously, we reported that repeated oral treatment with etoposide (ETP) increased ileal membrane localization of P-glycoprotein (P-gp) and that this was possibly mediated by increased expression of the ezrin/radixin/moesin (ERM)/phosphorylated ERM (p-ERM) via activation of RhoA/ROCK. These changes caused decreases i...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kobori T,Harada S,Nakamoto K,Tokuyama S

    更新日期:2013-05-01 00:00:00

  • Binding of imipramine, dosulepin, and opipramol to liposomes for overdose treatment.

    abstract::Polymer shielded liposomes were investigated as detoxifying agents for the weak bases imipramine and dosulepin and the diprotic drug opipramol. In vitro binding measurements in the presence of human serum samples revealed that the liposomes reduced the free drug concentration of the weak bases (corrected for protein b...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Howell BA,Chauhan A

    更新日期:2009-10-01 00:00:00

  • Liquid membrane phenomenon in diuretics.

    abstract::Surface activity and critical micelle concentrations are reported for two diuretic drugs, furosemide and triamterene. The drugs generate a liquid membrane on a supporting membrane. Transport of chloride, sodium, and potassium ions through the liquid membranes generated by the drugs was studied. The data suggest that t...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bhise SB,Bhattacharjee D,Srivastava RC

    更新日期:1984-11-01 00:00:00

  • Diphenhydramine disposition in the sheep maternal-placental-fetal unit: determinants of plasma drug concentrations in the mother and the fetus.

    abstract::The objective of this study was to identify the important factors that determine plasma concentrations of diphenhydramine (DPHM) in the mother and the fetus after maternal as well as fetal steady-state drug administration. Inter-relationships were evaluated between maternal and fetal placental and nonplacental clearan...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kumar S,Tonn GR,Riggs KW,Rurak DW

    更新日期:1999-12-01 00:00:00

  • Rational coformer or solvent selection for pharmaceutical cocrystallization or desolvation.

    abstract::It is demonstrated that the fluid-phase thermodynamics theory conductor-like screening model for real solvents (COSMO-RS) as implemented in the COSMOtherm software can be used for accurate and efficient screening of coformers for active pharmaceutical ingredient (API) cocrystallization. The excess enthalpy, H(ex) , be...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Abramov YA,Loschen C,Klamt A

    更新日期:2012-10-01 00:00:00

  • Bioavailability assessment under quasi- and nonsteady-state conditions III: Application.

    abstract::The applicability of bioavailability assessment at quasi- and nonsteady state is illustrated with data from a study comparing two formulations of amitriptyline hydrochloride in humans. Relative bioavailability as a function of the observed mean plasma concentrations may be expressed in closed form, provided the affect...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bondi JV,Hucker HB,Yeh KC,Kwan KC

    更新日期:1976-11-01 00:00:00

  • Preformulation-Assisted Design and Characterization of Modified Release Gastroretentive Floating Extrudates Towards Improved Bioavailability and Minimized Side Effects of Baclofen.

    abstract::Baclofen immediate release mode of administration exhibit sharp plasma peaking that results in the emergence of side effects like hypotension. This research employs preformulation studies to design an optimum dosage form for baclofen to enhance therapeutic outcomes. These studies include partition coefficient and ex-v...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ibrahim M,Naguib YW,Sarhan HA,Abdelkader H

    更新日期:2020-10-15 00:00:00

  • The Influence of In Vivo Metabolic Modifications on ADMET Properties of Green Tea Catechins-In Silico Analysis.

    abstract::The health effects of green tea are associated with catechins: (-)-epigallocatechin-3-O-gallate (EGCG), (-)-epigallocatechin, (-)-epicatechin-3-O-gallate, and (-)-epicatechin. An understanding of compound absorption, distribution, metabolism, excretion, and toxicity characteristics is essential for explaining its biol...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Matić S,Jadrijević-Mladar Takač M,Barbarić M,Lučić B,Gall Trošelj K,Stepanić V

    更新日期:2018-11-01 00:00:00

  • Partial molal volumes and solubilities of physostigmine in isopropanol:isopropyl myristate solvents in relation to skin penetrability.

    abstract::Partial molal volumes (Vi infinity) of physostigmine, ranging from 232.9 to 239.8 cm3.mol-1, and its mole fraction solubilities (Xi), ranging from 0.051 to 0.009, were determined at 25 degrees C in solutions of isopropanol (IPA), isopropyl myristate (IPM), and their mixtures. An inverse relation was found between Vi i...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Pardo A,Shiri Y,Cohen S

    更新日期:1991-06-01 00:00:00

  • Dissolution studies with a multichannel continuous-flow apparatus.

    abstract::A multichannel continuous-flow apparatus for dissolution rate measurements is described. Typical data are presented to demonstrate its utility for studies with bulk drug powders as well as with tablets and capsules without any change of setup. Procedures are given for the preparation of powder samples for dissolution ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cakiryildiz C,Mehta PJ,Rahmen W,Schoenleber D

    更新日期:1975-10-01 00:00:00

  • Metabolism of carprofen, a nonsteroid anti-inflammatory agent, in rats, dogs, and humans.

    abstract::The metabolic disposition of 14C-labeled carprofen [(+/-)-6-chloro-alpha-methylcarbazole-2-acetic acid] was investigated in rats, dogs, and humans. Carprofen is eliminated predominantly by biotransformation in these three species. In dogs and rats, the direct conjugation of carprofen to form an ester glucuronide and o...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Rubio F,Seawall S,Pocelinko R,DeBarbieri B,Benz W,Berger L,Morgan L,Pao J,Williams TH,Koechlin B

    更新日期:1980-11-01 00:00:00

  • Aromatic-aromatic interaction of amitriptyline: implication of overdosed drug detoxification.

    abstract::The objectives of this work are to explore the pi-pi complexation of amitriptyline with pi electron-deficient aromatic rings and demonstrate the feasibility of pi-pi complexation for overdosed drug detoxification. Water-soluble oligochitosan was chemically modified with dinitrobenzenesulfonyl groups to induce selectiv...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lee DW,Flint J,Morey T,Dennis D,Partch R,Baney R

    更新日期:2005-02-01 00:00:00

  • Progestin permeation through polymer membrane V: Progesterone release from monolithic hydrogel devices.

    abstract::Progesterone release from monolithic devices prepared from various copolymers of poly(hydroxyethyl methacrylate) and poly(methoxyethoxyethyl methacrylate) or poly(methoxyethyl methacrylate) was examined. In general, plots of the fraction of drug released versus (time)1/2 were linear during the early stages of drug rel...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Song SZ,Cardinal JR,Kim SH,Kim SW

    更新日期:1981-02-01 00:00:00

  • Novel pH-sensitive physical hydrogels of carboxymethyl scleroglucan.

    abstract::A carboxymethyl derivative of scleroglucan (Scl-CM) with derivatization degree 300 ± 10 was synthesized and characterized by Fourier transform infrared spectroscopy, potentiometer titration, mucus adhesion studies, and rheological measurements. Rheological measurements showed the ability of the polymer to undergo sol-...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Corrente F,Paolicelli P,Matricardi P,Tita B,Vitali F,Casadei MA

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  • Controlled and complete release of a model poorly water-soluble drug, prednisolone, from hydroxypropyl methylcellulose matrix tablets using (SBE)(7m)-beta-cyclodextrin as a solubilizing agent.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Rao VM,Haslam JL,Stella VJ

    更新日期:2001-07-01 00:00:00

  • Influence of asymmetric donor-receiver ion concentration upon transscleral iontophoretic transport.

    abstract::Recent in vitro and in vivo studies have suggested transscleral iontophoresis as a means for non-invasive drug delivery to the eye. However, there remains a lack of information of the iontophoretic transport behavior of the sclera. The objective of the present study was to investigate the effects of permeant concentra...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Li SK,Zhang Y,Zhu H,Higuchi WI,White HS

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  • Synthesis and characterization of pH tolerant and mucoadhesive (thiol-polyethylene glycol) chitosan graft polymer for drug delivery.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hauptstein S,Bonengel S,Griessinger J,Bernkop-Schnürch A

    更新日期:2014-02-01 00:00:00

  • Supersaturating drug delivery systems: fast is not necessarily good enough.

    abstract::An emerging technology subtype that has been adopted by formulators to address low-solubility issues is the supersaturating drug delivery system; this system is based on the "spring" and "parachute" design elements, which have been applied to lipid-based formulations, S(M)EDDS, solid dispersions, nano-based systems, a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Augustijns P,Brewster ME

    更新日期:2012-01-01 00:00:00

  • Progesterone retention by rat uterus I. Pharmacokinetics after uterine intraluminal instillation.

    abstract::Tritium-labeled progesterone was administered to mature female rats in the proestrous stage by three different routes, gastric intubation, subcutaneous injection, and uterine intraluminal instillation, to study the kinetics involved in the uptake and retention of radioactivity by the uterus and various other tissues. ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Fang SM,Lin CS,Lyon V

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  • GI absorption of beta-lactam antibiotics. III: Kinetic evidence for in situ absorption of ionized species of monobasic penicillins and cefazolin from the rat small intestine and structure-absorption rate relationships.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tsuji A,Miyamoto E,Kubo O,Yamana T

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  • Determination of binding affinity for chenodeoxycholate in equilibrium with sulfobutylether-β-cyclodextrin.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kokate A,Li X,Singh P,Jasti BR

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  • Prediction of the association state of insulin using spectral parameters.

    abstract::Human insulin exists in different association states, from monomer to hexamer, depending on the conditions. In the presence of zinc the "normal" state is a hexamer. The structural properties of 20 variants of human insulin were studied by near-UV circular dichroism, fluorescence spectroscopy, and small-angle X-ray sca...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Uversky VN,Garriques LN,Millett IS,Frokjaer S,Brange J,Doniach S,Fink AL

    更新日期:2003-04-01 00:00:00

  • Probing the Tryptophan Environment in Therapeutic Proteins: Implications for Higher Order Structure on Tryptophan Oxidation.

    abstract::Tryptophan (Trp) oxidation in proteins leads to a number of events, including changes in color, higher order structure (HOS), and biological activity. We describe here a number of new findings through a comprehensive characterization of 6 monoclonal antibodies (mAbs) following selective oxidation of Trp residues by 2,...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Barnett GV,Balakrishnan G,Chennamsetty N,Hoffman L,Bongers J,Tao L,Huang Y,Slaney T,Das TK,Leone A,Kar SR

    更新日期:2019-06-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Stewart JT,Honigberg IL,Coldren JW

    更新日期:1979-01-01 00:00:00

  • Influence of calcium ions on the structure and stability of recombinant human deoxyribonuclease I in the aqueous and lyophilized states.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chen B,Costantino HR,Liu J,Hsu CC,Shire SJ

    更新日期:1999-04-01 00:00:00

  • Understanding the Increased Aggregation Propensity of a Light-Exposed IgG1 Monoclonal Antibody Using Hydrogen Exchange Mass Spectrometry, Biophysical Characterization, and Structural Analysis.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bommana R,Chai Q,Schöneich C,Weiss WF 4th,Majumdar R

    更新日期:2018-06-01 00:00:00

  • Polymorphism of tedisamil dihydrochloride.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Henck JO,Finner E,Burger A

    更新日期:2000-09-01 00:00:00

  • Antitumor agents LV: Effects of genkwadaphnin and yuanhuacine on nucleic acid synthesis of P-388 lymphocytic leukemia cells.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hall IH,Kasai R,Wu RY,Tagahara K,Lee KH

    更新日期:1982-11-01 00:00:00

  • Anticonvulsant activity and selective inhibition of nicotinamide adenine dinucleotide-dependent oxidations by 10-(2-arylimino-3-acetylamino-4-thiazolidonyl) phenothiazines.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Singh SP,Ali B,Auyong TK,Parmar SS,De Boer B

    更新日期:1976-03-01 00:00:00