Abstract:
:Racemic and homochiral sodium ibuprofen were characterized by thermal analysis and powder X-ray diffractometry. The melting point phase diagram was constructed and thermodynamic calculation was performed. In contrast to racemic ibuprofen, which is a racemic compound, racemic sodium ibuprofen forms both a racemic conglomerate (termed the gamma-form) as well as two polymorphic racemic compounds, alpha and beta, which are less stable monotropes. From the supercooled liquid, alpha and beta crystallized along with the original gamma-form. Forms alpha and beta are "enantiotropically related" with a transition temperature between 75 degrees and 113 degrees C, but can be considered to be metastable monotropes of the racemic conglomerate, the stable gamma-form.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Zhang GG,Paspal SY,Suryanarayanan R,Grant DJdoi
10.1002/jps.10393subject
Has Abstractpub_date
2003-07-01 00:00:00pages
1356-66issue
7eissn
0022-3549issn
1520-6017pii
S0022-3549(16)31285-0journal_volume
92pub_type
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