Abstract:
:The cyclopropyl amine moiety in GSK2879552 (1) degrades hydrolytically in high pH conditions. This degradation pathway was observed during long-term stability studies and impacted the shelf life of the drug product. This article describes the work to identify the degradation impurities, elucidate the degradation mechanism, and design a stable drug product. It was found that salt selection and control of the microenvironmental pH of the drug product formulation blend significantly improved the chemical stability of the molecule in the solid state.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Campbell JM,Lee M,Clawson J,Kennedy-Gabb S,Bethune S,Janiga A,Kindon L,Leach KPdoi
10.1016/j.xphs.2019.04.026subject
Has Abstractpub_date
2019-09-01 00:00:00pages
2858-2864issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(19)30294-1journal_volume
108pub_type
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