Abstract:
:Various multiparticulate dissolution models that assume a log-normal particle-size distribution are fitted by nonlinear least-squares regression to data from the dissolution of micronized glyburide. Estimates of parameters describing the effective initial particle-size distribution are obtained, together with estimates of the specific dissolution rate parameter. A dissolution equation based on an ideal, untruncated, log-normal distribution, with the single particles dissolving according to the Hixson-Crowell cube root law, is the best model. The dissolution behavior of glyburide can be well described by this model in terms of the specific dissolution rate parameter and one other parameter accounting for the distribution effect. The estimation of these two parameters represents a more exact way of describing the dissolution characteristics of drug powders than previous approaches. The method should be of interest in the quality control of drugs that may cause bioavailability problems because of dissolution rate-limited absorption.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Pedersen PVdoi
10.1002/jps.2600660603subject
Has Abstractpub_date
1977-06-01 00:00:00pages
761-6issue
6eissn
0022-3549issn
1520-6017pii
S0022-3549(15)39388-6journal_volume
66pub_type
杂志文章abstract::The expression of carboxylesterase (CES) and the transdermal movement of an ester prodrug were studied in rat skin. Ethyl-fexofenadine (ethyl-FXD) was used as a model lipophilic prodrug that is slowly hydrolyzed to its parent drug, FXD (MW 502). Among the CES1 and CES2 isozymes, Hydrolase A is predominant in rat skin ...
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journal_title:Journal of pharmaceutical sciences
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journal_title:Journal of pharmaceutical sciences
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of pharmaceutical sciences
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doi:10.1002/jps.2600640909
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journal_title:Journal of pharmaceutical sciences
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