Abstract:
:Employing the roots of Iris missouriensis, two known triterpenes, iso-iridogermanal and zeorin, were isolated and identified. As presently reported, they were found to demonstrate cytotoxic activity toward cultured P-388 cells (ED50 = 0.1 and 1.1 microgram/mL, respectively). Additionally, a new triterpene that demonstrated an ED50 of 8.5 micrograms/mL was isolated. On the basis of spectral analysis and chemical correlation with zeorin, the structure was shown to be 6 6 alpha-hydroxy-A'-neogermmacer-22(29)-en-30-oic acid (missourin).
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Wong SM,Oshima Y,Pezzuto JM,Fong HH,Farnsworth NRdoi
10.1002/jps.2600750324subject
Has Abstractpub_date
1986-03-01 00:00:00pages
317-20issue
3eissn
0022-3549issn
1520-6017pii
S0022-3549(15)47062-5journal_volume
75pub_type
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