Abstract:
:The hydrophobic substituent parameter for a system of meta- and para-disubstituted benzenes, XC6H4Y, defined as pi X/PhY = log PXC6H4Y - log PC6H5Y, where P is the octanol-water partition coefficient and X and Y are variable and fixed substituents, respectively, varies from one system to another, according to the variation in substituent effects on the hydrogen bonding association of substituents with solvents. Using parameters from monosubstituted benzenes, pi X/PhH as the reference, the pi X values were analyzed by such relations as pi X/PhY = a pi X/PhH + rho Y sigma X + rho X sigma Y, where rho Y and rho X are susceptibilities of the relative hydrogen bonding association of substituents Y and X with two partitioning solvents to the electronic effect of X and Y, respectively. For substituents incapable of hydrogen bonding such as alkyl and halogen, the rho value is 0. The parameter a is a constant congruent to 1. The relationship was applied in calculating log P values of disubstituted benzenes.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Fujita Tdoi
10.1002/jps.2600720319subject
Has Abstractpub_date
1983-03-01 00:00:00pages
285-9issue
3eissn
0022-3549issn
1520-6017pii
S0022-3549(15)44527-7journal_volume
72pub_type
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journal_title:Journal of pharmaceutical sciences
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journal_title:Journal of pharmaceutical sciences
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journal_title:Journal of pharmaceutical sciences
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abstract::Different approaches for the colorimetric determination of acetaminophen, based on its coupling with diazotized o-nitroaniline, are described. Copper(II) chelation with the coupled compound makes the method highly selective. Sensitivity is increased when the acetaminophen assay is carried out indirectly through the de...
journal_title:Journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.1002/jps.2600680626
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doi:10.1002/jps.2600640823
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journal_title:Journal of pharmaceutical sciences
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journal_title:Journal of pharmaceutical sciences
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doi:10.1002/jps.2600750608
更新日期:1986-06-01 00:00:00
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abstract::The crystal structure of zolpidem hemitartrate hemihydrate (I, Form E) has been solved from high-resolution laboratory powder diffraction data. It crystallizes in the orthorhombic P2(1)2(1)2(1) space group with a = 22.4664(6) A, b = 26.0420(7) A, and c = 7.4391(1) A. Protonation of zolpidem molecules could not be unam...
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abstract::The purpose of this paper was to investigate the relaxation behavior of amorphous hesperetin (HRN), using dielectric spectroscopy, and assessment of its crystallization kinetics above glass transition temperature (Tg ). Amorphous HRN exhibited both local (β-) and global (α-) relaxations. β-Relaxation was observed belo...
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abstract::In this paper, we establish a mechanistic model for the prediction of amorphous solid dispersion (ASD) stability. The novel approach incorporates fundamental physical parameters, principally supersaturation, diffusivity, and interfacial energy, to model crystallization in ASDs accounting for both kinetic and thermodyn...
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