Thermodynamic analysis of energy dissipation by pharmaceutical tablets during stress unloading.


:A thermodynamic analysis of the energy transformations occurring within pharmaceutical tablets during the unloading phase of compaction was performed on Avicel, calcium phosphate, acetaminophen, and calcium oxalate. This analysis was based on viscoelastic stress data collected using an instrumented rotary press and was conducted for the purpose of determining the extent and nature of energy release, beyond that of force displacement, during this phase of compaction. The four materials investigated were selected to reflect a range of compaction properties, and the viscous vs force-displacement energy distributions were seen to be consistent with their brittle vs plastic character. Magnesium stearate, added in various concentrations up to 4% w/w, was found to act both as an internal lubricant for particle-particle slipping and as a moderator of interparticulate bonding.


J Pharm Sci


Hoag SW,Rippie EG




Has Abstract


1994-06-01 00:00:00














  • Particle diffusional layer thickness in a USP dissolution apparatus II: a combined function of particle size and paddle speed.

    abstract::This work was to investigate the effects of particle size and paddle speed on the particle diffusional layer thickness h(app) in a USP dissolution apparatus II. After the determination of the powder dissolution rates of five size fractions of fenofibrate, including <20, 20-32, 32-45, 63-75, and 90-106 microm, the pres...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sheng JJ,Sirois PJ,Dressman JB,Amidon GL

    更新日期:2008-11-01 00:00:00

  • Acetaminophen inhibits intestinal p-glycoprotein transport activity.

    abstract::Repeated acetaminophen (AP) administration modulates intestinal P-glycoprotein (P-gp) expression. Whether AP can modulate P-gp activity in a short-term fashion is unknown. We investigated the acute effect of AP on rat intestinal P-gp activity in vivo and in vitro. In everted intestinal sacs, AP inhibited serosal-mucos...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Novak A,Carpini GD,Ruiz ML,Luquita MG,Rubio MC,Mottino AD,Ghanem CI

    更新日期:2013-10-01 00:00:00

  • Ultracentrifugal study of effect of sodium chloride on micelle size of fusidate sodium.

    abstract::Apparent micellar molecular weights were determined with the antibiotic fusidate sodium by ultracentrifugation in varying counterion concentrations (Na+). The effects of buffer salts, pH, sodium chloride concentration, and drug concentration were studied. The results strongly support the concept of the formation of pr...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Richard AJ

    更新日期:1975-05-01 00:00:00

  • Density and Shape Factor Terms in Stokes' Equation for Aerodynamic Behavior of Aerosols.

    abstract::Pharmaceutical aerosols are used to treat many pulmonary diseases. The use of low-density powders has proven useful to support efficient drug delivery. Measurements must account for the low-density, spherical particle features contributing to aerodynamic behavior. Ideally, the aerodynamic particle size distribution (A...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hickey AJ,Edwards DA

    更新日期:2018-03-01 00:00:00

  • Determination of diphenoxylate hydrochloride and atropine sulfate in solutions and tablets.

    abstract::Methods for the determination of diphenoxylate hydrochloride and atropine sulfate combinations in solutions and powdered tablet composites are presented. A semiautomated assay for diphenoxylate hydrochloride in individual tablets (content uniformity) also is presented. The USP XIX assays for these products are cumbers...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ballbach RL,Brown DJ,Walters SM

    更新日期:1977-11-01 00:00:00

  • Impact of Freeze/Thaw Process on Drug Substance Storage of Therapeutics.

    abstract::The storage of drug substance at subzero temperatures mitigates potential risks associated with liquid storage, such as degradation and shipping stress, making it the best solution for long-term storage. However, slower (generally uncontrolled) rates of freezing and thawing of drug substance in conventional large stor...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Rayfield WJ,Kandula S,Khan H,Tugcu N

    更新日期:2017-08-01 00:00:00

  • Titanium dioxide-montmorillonite nanocomposite as photoprotective agent against ultraviolet B radiation-induced mutagenesis in Saccharomyces cerevisiae: a potential candidate for safer sunscreens.

    abstract::Photoprotective potential and biological consequences (mutagenic potential) of octyl-dimethyl-PABA (ODP), titanium dioxide (TiO2 ), and montmorillonite (MMT) upon ultraviolet B (UVB) irradiation, alone and in different associations [physical mixtures (PMs)], were evaluated using a Saccharomyces cerevisiae ogg1 mutant ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Paiva JP,Santos BA,Kibwila DM,Gonçalves TC,Pinto AV,Rodrigues CR,Leitão AC,Cabral LM,De Pádula M

    更新日期:2014-08-01 00:00:00

  • Protein transduction domain-containing microemulsions as cutaneous delivery systems for an anticancer agent.

    abstract::In this study, we developed cationic microemulsions containing a protein transduction domain (penetratin) for optimizing paclitaxel localization within the skin. Microemulsions were prepared by mixing a surfactant blend (BRIJ:ethanol:propylene glycol 2:1:1, w/w/w) with monocaprylin (oil phase) at 1.3:1 ratio, and addi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Pepe D,McCall M,Zheng H,Lopes LB

    更新日期:2013-05-01 00:00:00

  • Partial molal volumes and solubilities of physostigmine in isopropanol:isopropyl myristate solvents in relation to skin penetrability.

    abstract::Partial molal volumes (Vi infinity) of physostigmine, ranging from 232.9 to 239.8 cm3.mol-1, and its mole fraction solubilities (Xi), ranging from 0.051 to 0.009, were determined at 25 degrees C in solutions of isopropanol (IPA), isopropyl myristate (IPM), and their mixtures. An inverse relation was found between Vi i...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Pardo A,Shiri Y,Cohen S

    更新日期:1991-06-01 00:00:00

  • Stress Temperature Studies in Small Scale Hastelloy® Drug Substance Containers Lead to Increased Extent of and Increased Variability in Antibody-Drug Conjugate and Monoclonal Antibody Aggregation: Evidence for Novel Oxidation-Induced Crosslinking in Monoc

    abstract::Health authorities require that suitable stability of the drug substance be shown in relevant materials of construction. ICH Q1A(R2) explicitly states that "stability studies should be conducted on drug substance packaged in a container closure system that is the same as or simulates the packaging proposed for storage...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Klair N,Kim MT,Lee A,Xiao NJ,Patel AR

    更新日期:2020-10-07 00:00:00

  • Comparison of granule strength and tablet tensile strength.

    abstract::The granule strength (crushing load) of lactose granulated with 1-9% povidone was measured initially and at intervals during a 1-year period. The granule strengths of dibasic calcium phosphate dihydrate granulated with various concentrations of starch and povidone were measured. The axial and radial tensile strengths ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Jarosz PJ,Parrott EL

    更新日期:1983-05-01 00:00:00

  • Electromigration of ions across the skin: determination and prediction of transport numbers.

    abstract::In iontophoresis, an electric field across the skin induces electromigration of exogenously applied and endogenously present ions. The approach can be used to improve dramatically drug delivery by elimination of competing co-ions in the externally applied formulation, as this maximizes the fraction of current carried ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Mudry B,Guy RH,Delgado-Charro MB

    更新日期:2006-03-01 00:00:00

  • Drug Distribution to Human Tissues: Prediction and Examination of the Basic Assumption in In Vivo Pharmacokinetics-Pharmacodynamics (PK/PD) Research.

    abstract::The tissue:plasma partition coefficients (Kp ) are good indicators of the extent of tissue distribution. Therefore, advanced tissue composition-based models were used to predict the Kp values of drugs under in vivo conditions on the basis of in vitro and physiological input data. These models, however, focus on animal...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Poulin P

    更新日期:2015-06-01 00:00:00

  • Stability of aqueous solutions of pirbuterol.

    abstract::The hydrolytic degradation of pirbuterol was investigated under saturated oxygen conditions over a wide range of pH values and at different temperatures. Two of the five observed breakdown products were positively identified. The first-order decomposition rate appeared to depend on the rate constants of the four disso...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bansal PC,Monkhouse DC

    更新日期:1977-06-01 00:00:00

  • Correlation of log P with molecular connectivity in hydroxyureas: influence of conformational system on log P.

    abstract::The correlation of log P (in octanol--water) with the nonempirical, topologically dependent, calculated molecular connectivity index (1chiv) delineates substituted hydroxyureas into two families of linearly related groups of compounds. The first group, composed of the 3-substituted ethyl, n-propyl, and n-butyl analogs...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Parker GR

    更新日期:1978-04-01 00:00:00

  • A method to predict the equilibrium solubility of drugs in solid polymers near room temperature using thermal analysis.

    abstract::A method is presented for determining the equilibrium solubility of a drug in a solid polymer at or near room temperature, which represents a typical storage temperature. The method is based on a thermodynamic model to calculate the Gibbs energy change ΔG(SS) associated with forming a binary drug-polymer solid solutio...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bellantone RA,Patel P,Sandhu H,Choi DS,Singhal D,Chokshi H,Malick AW,Shah N

    更新日期:2012-12-01 00:00:00

  • A mechanistic study of griseofulvin dissolution into surfactant solutions under laminar flow conditions.

    abstract::The in vivo dissolution of many poorly soluble drugs is enhanced by the action of surfactants secreted into the upper gastrointestinal (GI) tract. These substances may act by solubilizing individual drug molecules into two separate liquid phases: the free aqueous phase and a micellar phase in which the drug is incorpo...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Rao VM,Lin M,Larive CK,Southard MZ

    更新日期:1997-10-01 00:00:00

  • Thermodynamic Estimate of the Number of Solvent Molecules Displaced by a Solute Molecule for Enthalpy-Driven Adsorption: Phenobarbital and Activated Carbons as the Model System.

    abstract::A Modified Crisp Equation, describing the differential Gibbs free energy of the adsorption process, is being proposed, which considers multiple sites available on the surface for adsorption and their relative fractions. The differential Gibbs free energy can be calculated by the van't Hoff Equation, which depends on t...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Yu P,Wurster DE

    更新日期:2018-04-01 00:00:00

  • Hybrid films from blends of chitosan and egg phosphatidylcholine for localized delivery of paclitaxel.

    abstract::Chitosan and egg phosphatidylcholine (ePC) were used as a unique combination to prepare composite films for localized drug delivery. In comparison to other phospholipids analyzed, ePC was found to produce chitosan-based films with minimal swelling and a high degree of stability. The properties of the chitosan-ePC film...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Grant J,Blicker M,Piquette-Miller M,Allen C

    更新日期:2005-07-01 00:00:00

  • Multivariate parameter evaluation of pharmaceutically important cellulose ethers.

    abstract::A set of nonionic cellulose ethers with varying hydrophobicity and molecular weight has been investigated by principal component analysis (PCA). Several experimental variables such as dynamic surface tension, diffusion coefficient, microviscosity as monitored by a fluorescence probe technique, and intrinsic viscosity ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Persson B,Evertsson H,Bergman R,Sundelöf LO

    更新日期:1999-08-01 00:00:00

  • Disposition of norgestimate in the presence and absence of ethinyl estradiol after oral administration to humans.

    abstract::The disposition of radioactivity following oral administration of 14C-norgestimate was compared to that following administration of the drug in combination with 3H-ethinyl estradiol in humans. Seven normal, healthy female subjects were each administered one capsule orally containing 14C-norgestimate either alone (74.4...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Weintraub HS,Abrams LS,Patrick JE,McGuire JL

    更新日期:1978-10-01 00:00:00

  • Econazole nitrate-loaded MCM-41 for an antifungal topical powder formulation.

    abstract::The aim of this article was to prepare a topical powder for the treatment of fungal infections, such as Candida intertrigo and tinea pedis. Thus, an econazole nitrate (ECO) formulation with improved drug dissolution and proper moisture adsorption was designed. ECO was melt with the mesoporous silicate MCM-41 (drug/MCM...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ambrogi V,Perioli L,Pagano C,Marmottini F,Moretti M,Mizzi F,Rossi C

    更新日期:2010-11-01 00:00:00

  • Preparation of pH-sensitive beads for NSAID using three-component gel systems.

    abstract::The aim of this study is to prepare novel pH-sensitive beads to obtain a gastric mucosa protective formulation and to ensure drug delivery into the intestine. Diclofenac sodium was used as a model drug. Bead formation was achieved by ionotropic gelation method using three-component gel system containing sodium alginat...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Fenyvesi Z,Auner A,Schmalz D,Pásztor E,Csóka G,Gyires K,Marton S,Klebovich I,Antal I

    更新日期:2009-11-01 00:00:00

  • Effect of inorganic additives on solutions of nonionic surfactants III: CMC's and surface properties.

    abstract::Continuing work on the interaction of inorganic additives with nonionic surfactants in aqueous solution dealt with their effect on the CMC and surface tension. The surfactants were octoxynol and polyoxyethylated oleyl alcohol, containing an average of 9.5 and 10 ethylene oxide units, respectively. Their CMC values wer...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Schott H,Han SK

    更新日期:1976-07-01 00:00:00

  • Enhanced econazole penetration into human nail by 2-n-nonyl-1,3-dioxolane.

    abstract::This study determines the enhancing effects of 2-n-nonyl-1,3-dioxolane on the penetration of econazole, an antifungal drug, into the deeper layers of the human nail where fungal infection resides. Aliquots (10 microL) of Econail lacquer formulation containing 0.45 mg of [(14)C]-econazole with 18% 2-n-nonyl-1,3-dioxola...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hui X,Chan TC,Barbadillo S,Lee C,Maibach HI,Wester RC

    更新日期:2003-01-01 00:00:00

  • A triple-transgenic immunotolerant mouse model.

    abstract::Avoiding unwanted immunogenicity is of key importance in the development of therapeutic drug proteins. Animal models are of less predictive value because most of the drug proteins are recognized as foreign proteins. However, different methods have been developed to obtain immunotolerant animal models. So far, the immu...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Brenden N,Madeyski-Bengtson K,Martinsson K,Svärd R,Albery-Larsdotter S,Granath B,Lundgren H,Lövgren A

    更新日期:2013-03-01 00:00:00

  • Development of a Stable Liquid Formulation for Live Attenuated Influenza Vaccine.

    abstract::Live attenuated influenza vaccine (LAIV) is considered one of the most effective vaccines and can be manufactured quickly and inexpensively to counter seasonal or pandemic influenza. Lyophilization is widely used in vaccine production. However, it requires a longer production cycle and large-scale equipment, thus posi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sun Y,Shen Z,Zhang C,Yi Y,Zhu K,Xu F,Kong W

    更新日期:2019-07-01 00:00:00

  • The use of xanthan gum in an ophthalmic liquid dosage form: rheological characterization of the interaction with mucin.

    abstract::The development of an ocular dosage form containing xanthan gum and capable of interacting with mucin in the precorneal area is a challenge. The polymer concentration that can be applied is restricted because of the limited patient acceptability of highly viscous preparations. The precorneal mucin concentration is low...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ceulemans J,Vinckier I,Ludwig A

    更新日期:2002-04-01 00:00:00

  • Investigation of the Changes in Aerosolization Behavior Between the Jet-Milled and Spray-Dried Colistin Powders Through Surface Energy Characterization.

    abstract::This study aimed to investigate the surface energy factors behind improved aerosolization performance of spray-dried colistin powder formulations compared with those produced by jet milling. Inhalable colistin powder formulations were produced by jet milling or spray drying (with or without l-leucine). Scanning electr...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Jong T,Li J,Morton DA,Zhou QT,Larson I

    更新日期:2016-03-01 00:00:00

  • Determination of dextromethorphan hydrobromide by high-performance liquid chromatography using ion-pair formation.

    abstract::The chromatographic retention behavior of dextromethorphan hydrobromide on an octadecylsilane column was investigated as a function of the pairing ion and the mobile phase composition. Dramatic increases in the capacity factor were observed with pairing ions containing more than eight carbons and with decreasing organ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kubiak EJ,Munson JW

    更新日期:1980-12-01 00:00:00