Abstract：
:The aims of the present study were to formulate stable onion phases of the biodegradable surfactant PEG-8 Distearate (PEG8DS) and evaluate application of the onion phases in encapsulating sumatriptan succinate, a BCS class III potent antimigraine drug. Drug loaded and placebo onion phases were prepared by shearing lyotropic lamellar phases of the surfactant. Effect of drug/surfactant ratio, shear rate and shear time on particle size, and encapsulation efficiency were studied. The onion phases were characterized by polarized microscopy, small angle neutron scattering (SANS), NMR, rheology, and FTIR. Formation of onion phases of PEG8DS was confirmed by the presence of maltese crosses under a crosspolarized microscope and further by SANS studies. The onion phases revealed an increase of inter-bilayer spacing by 7 A after drug incorporation. NMR studies revealed location of drug in the aqueous phases of the multilamellar vesicles (MLVs). FTIR study revealed no interaction between drug and surfactant. Drug loaded onion phases exhibited high encapsulation efficiency ( approximately 90%) and rapid in vitro drug release (>90% in 10 min). Onion phases stored at 5 degrees C +/- 3 degrees C revealed no significant drug leakage at the end of 3 months suggesting adequate stability. Sumatriptan succinate loaded stable onion phases of PEG8DS with high entrapment efficiency and rapid drug release suggests potential application of the onion phases in drug delivery.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Redkar M,Hassan PA,Aswal V,Devarajan Pdoi
10.1002/jps.20863subject
Has Abstractpub_date
2007-09-01 00:00:00pages
2436-45issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(16)32348-6journal_volume
96pub_type
杂志文章abstract：:Alpha-Hydroxyaryl ketones such as 2-hydroxypropiophenone and 1-(2,4-difluorophenyl)-2-hydroxy-1-propanone, the key intermediates in the preparation of antifungal agents, decompose into oxidized, rearranged, and condensed products. These products were isolated and characterized. The possible mechanisms for the formatio...
journal_title：Journal of pharmaceutical sciences
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更新日期：2004-09-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：1982-12-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：2013-05-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1016/j.xphs.2019.02.020
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.10023
更新日期：2002-01-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：2009-05-01 00:00:00
abstract：:Two oral liquid dosage forms of acetazolamide have been developed. Using the solubility profiles, polyethylene glycol 400 (7%, v/v) was used as the solubilizing agent and propylene glycol (53%, v/v) as the cosolvent to keep acetazolamide in solution. Because of the bitter taste of acetazolamide, sweetening agents (sim...
journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600790919
更新日期：1990-09-01 00:00:00
abstract：:We have used rheological and thermal methods to study the colloidal characteristics of a widely used technical latex. The dispersions of poly(methacrylic acid-ethyl acrylate) (Eudragit L100-55) were found to be stabilized by a combination of electrostatic and steric mechanisms termed as electrosteric stabilization. Th...
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更新日期：1999-04-01 00:00:00
abstract：:A simultaneous GLC determination for methyl salicylate and menthol in a topical analgesic formulation is reported. n-Nonadecane is used as the internal standard. The method is rapid, accurate, precise, and selective in the presence of salicylic acid and ethyl salicylate. ...
journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600680431
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abstract：:Recent studies have clearly demonstrated that Fourier transform IR spectroscopy can be a powerful tool for the study of protein stabilization during freeze-drying and for optimizing approaches to prevent lyophilization-induced protein aggregation. The purpose of the current review is to provide an overview of these to...
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章,评审
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更新日期：2000-08-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：1975-06-01 00:00:00
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更新日期：2005-03-01 00:00:00
abstract：:The transport rate constant of a drug partitioned in a two-phase system from an aqueous to an organic phase (k1obs) and vice versa (k2obs) is a function of the partition coefficient P and of a solvent system-dependent parameter beta. Drug transport is shown to be independent of molecular structure for a number of arbi...
journal_title：Journal of pharmaceutical sciences
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更新日期：1981-09-01 00:00:00
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更新日期：2008-10-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：1986-08-01 00:00:00
abstract：:99mTc-N-(3-bromo-2,4,6-trimethylacetanilide)iminodiacetat e (I) and 99mTc-N-pyridoxyl-5-methyl-tryptophan (II) have been described as having optimal properties as hepatobiliary radiopharmaceuticals. This study compared specificity for hepatobiliary excretion, blood disappearance, rates of biliary appearance, and pharm...
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abstract：:Two multisample laboratory powder diffractometers have been evaluated for the purpose of pattern indexing in the context of physical form screening. Both diffractometers utilise foil transmission geometry, primary monochromated radiation, and a position-sensitive detector. Data collected from six compounds (sotalol hy...
journal_title：Journal of pharmaceutical sciences
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更新日期：2003-09-01 00:00:00
