Abstract:
:In this contribution, we present an analysis of the main parameters influencing the efficiency of the (1)H → (13)C multiple-contact cross-polarization nuclear magnetic resonance (NMR) experiment in the context of solid pharmaceutical materials. Using the optimum experimental conditions, quantitative (13)C NMR spectra are then obtained for porous metal-organic frameworks (potential drug carriers) and for components present in drug formulations (active principle ingredient and excipients, amorphous or crystalline). Finally, we show that mixtures of components can also be quantified with this method and, hence, that it represents an ideal tool for quantification of pharmaceutical formulations by (13)C cross-polarization under magic-angle spinning NMR in the industry as it is robust and easy to set up, much faster than direct (13)C polarization and is efficient for samples at natural abundance.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Saïdi F,Taulelle F,Martineau Cdoi
10.1016/j.xphs.2016.05.025subject
Has Abstractpub_date
2016-08-01 00:00:00pages
2397-401issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(16)41461-9journal_volume
105pub_type
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