Simple rapid method for the preparation of enteric-coated microspheres.


:A method is presented for encapsulating high molecular weight biological materials such as viral antigen, concanavalin A, and other proteins with cellulose acetate phthalate. The method is simple, inexpensive, and rapid; the process takes approximately 15 min. Capsules generated by this method are produced as microspheres 1-3 mm in diameter. They are stable for at least 6 h in simulated gastric conditions, but disintegrate rapidly under simulated intestinal conditions. Encapsulation had no effect on the activity of the biological materials. The method has potentially wide application for encapsulation of drugs and other substances.


J Pharm Sci


Maharaj I,Nairn JG,Campbell JB




Has Abstract


1984-01-01 00:00:00














  • Novel surface-modified nanostructured lipid carriers with partially deacetylated water-soluble chitosan for efficient ocular delivery.

    abstract::The objective of this study was to propose novel surface-modified nanostructured lipid carriers with partially deacetylated water-soluble chitosan (NLC-PDSC) as an efficient ocular delivery system to improve its transcorneal penetration and precorneal retention. PDSC with a deacetylation degree of around 50% was synth...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tian B,Luo Q,Song S,Liu D,Pan H,Zhang W,He L,Ma S,Yang X,Pan W

    更新日期:2012-03-01 00:00:00

  • Effects of taraxacum mongolicum on the bioavailability and disposition of ciprofloxacin in rats.

    abstract::Taraxacum mongolicum (TM), also known as dandelion, is a herb widely used in the East for its antibacterial activity. The high mineral content of TM presents a potential problem for the absorption of quinolone antibiotics. This study was undertaken to discern the significance of a drug-drug interaction between TM and ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Zhu M,Wong PY,Li RC

    更新日期:1999-06-01 00:00:00

  • Characterization of a Stable 2,2'-Azobis(2-Methylpropanenitrile) Degradant and Its Use to Monitor the Oxidative Environment During Forced Degradation Studies by Liquid Chromatography/Mass Spectrometry.

    abstract::Azo compounds are commonly used to study radical-mediated degradation of pharmaceutical compounds. The favorable chemical and physical properties of 2,2'-azobis(2-methylpropanenitrile) (AIBN) have made it one of the most widely used compound for these type of studies. This article describes the characterization of a s...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wells-Knecht KJ,Dunn D

    更新日期:2019-09-01 00:00:00

  • Impact of glass corrosion on drug substance stability.

    abstract::The delamination of glass contact surfaces because of hydrolytic instability has been well documented. However, the lack of glass surface integrity can also lead to other undesirable outcomes prior to visible glass delamination. This work shows how the early stages of delamination, namely, glass corrosion, can influen...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Watkins MA,Iacocca RG,Shelbourn TL,Dong X,Stobba-Wiley C

    更新日期:2014-08-01 00:00:00

  • Carfilzomib Delivery by Quinic Acid-Conjugated Nanoparticles: Discrepancy Between Tumoral Drug Accumulation and Anticancer Efficacy in a Murine 4T1 Orthotopic Breast Cancer Model.

    abstract::Despite being a major breakthrough in multiple myeloma therapy, carfilzomib (CFZ, a second-generation proteasome inhibitor drug) has been largely ineffective against solid cancer, possibly due to its pharmacokinetic drawbacks including metabolic instability. Recently, quinic acid (QA, a low-affinity ligand of selectin...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Jun Y,Xu J,Kim H,Park JE,Jeong YS,Min JS,Yoon N,Choi JY,Yoo J,Bae SK,Chung SJ,Yeo Y,Lee W

    更新日期:2020-04-01 00:00:00

  • Interactions of cyclosporines with lipid membranes as studied by solid-state nuclear magnetic resonance spectroscopy and high-sensitivity titration calorimetry.

    abstract::Cyclosporin A (CyA) interacts with lipid membranes. Binding reaction and membrane location of CyA and analogs were examined with 2H-NMR, high-sensitivity isothermal titration calorimetry (ITC), and CD spectroscopy. Effects of CyA and charged analogs on the phosphocholine head group and on the membrane interior were in...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Schote U,Ganz P,Fahr A,Seelig J

    更新日期:2002-03-01 00:00:00

  • Biochemical investigation of active intracellular transport of polymeric gene-delivery vectors.

    abstract::To design safe, efficient synthetic gene therapy vectors, it is desirable to understand the intracellular mechanisms that facilitate their delivery from the cell surface to the nucleus. Elements of the cytoskeleton and molecular motor proteins are known to play a pivotal role in most intracellular active transport pro...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Drake DM,Pack DW

    更新日期:2008-04-01 00:00:00

  • Characterization of the properties of cocaine in blood: blood clearance, blood to plasma ratio, and plasma protein binding.

    abstract::As part of a study to examine cocaine disposition and interaction with ethanol, it was necessary to characterize various properties of cocaine in the blood of the experimental animal. All studies were conducted using blood from healthy adult male Sprague-Dawley rats. Cocaine was incubated in whole blood at 37 degrees ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sukbuntherng J,Martin DK,Pak Y,Mayersohn M

    更新日期:1996-06-01 00:00:00

  • Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection.

    abstract::The insidious nature of Zika virus (ZIKV) infections can have a devastating consequence for fetal development. Recent reports have highlighted that chloroquine (CQ) is capable of inhibiting ZIKV endocytosis in brain cells. We applied pharmacokinetic modeling to develop a predictive model for CQ exposure to identify an...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Olafuyi O,Badhan RKS

    更新日期:2019-01-01 00:00:00

  • Enhancement of the rectal absorption of sodium ampicillin by N-acylamino acids in rats.

    abstract::The promoting efficacies of N-acyl derivatives of amino acids on the rectal absorption of sodium ampicillin were investigated using the rat rectal loop technique. N-Acyl derivatives with longer carbon chains in the acyl moiety showed a greater promoting potency. The promoting potencies of N-acyl derivatives of phenylg...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wu WM,Murakami T,Higashi Y,Yata N

    更新日期:1987-07-01 00:00:00

  • The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping.

    abstract::The purpose of the present study was to develop a physiologically based pharmacokinetic model for dextromethorphan (DEX) and its metabolites in extensive and poor metabolizers. The model was used to study the influence of dissolution rates on the sensitivity of maximum plasma concentration and area under the concentra...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bolger MB,Macwan JS,Sarfraz M,Almukainzi M,Löbenberg R

    更新日期:2019-01-01 00:00:00

  • TLC differentiation of butyrophenone and diphenylbutylpiperidine compounds from phenothiazine derivatives.

    abstract::A procedure is described for TLC detection and differentiation of the butyrophenone-diphenylbutylpiperidine group and phenothiazine derivatives at the microgram level. A two-dimensional TLC method to separate butyrophenone and diphenylbutylpiperidine compounds is reported. A variety of possible detection reagents were...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Pluym A

    更新日期:1979-08-01 00:00:00

  • Regulation of Tight-Junction Integrity by Insulin in an In Vitro Model of Human Blood-Brain Barrier.

    abstract::Although insulin receptor is expressed at the human blood-brain barrier (BBB), the physiological and pathologic roles of insulin signaling in biologic responses at the BBB remain unclear. Here, we investigate insulin signaling at the human BBB using human cerebral microvascular endothelial cell line (hCMEC/D3) as a we...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ito S,Yanai M,Yamaguchi S,Couraud PO,Ohtsuki S

    更新日期:2017-09-01 00:00:00

  • A novel off-center paddle impeller (OPI) dissolution testing system for reproducible dissolution testing of solid dosage forms.

    abstract::Dissolution testing is routinely conducted in the pharmaceutical industry to provide in vitro drug release information for quality control purposes. The most common dissolution testing system for solid dosage forms is the United States Pharmacopeia (USP) Dissolution Testing Apparatus 2. This apparatus is very sensitiv...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wang Y,Armenante PM

    更新日期:2012-02-01 00:00:00

  • Constant returns to scale for prescription dispensing in U.S. community pharmacy.

    abstract::By using data from a sample of 1767 community pharmacies, a total cost function was estimated by a polynomial regression of total cost on output. The Cobb-Douglas production function was estimated by a multiple linear regression of natural logarithmic transformations of output on natural logarithmic transformation of ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lohrisch D,Shull SC,Smith MC

    更新日期:1976-02-01 00:00:00

  • Chloride ion nuclear magnetic resonance spectroscopy probe studies of copper and nickel binding to serum albumins.

    abstract::The binding of Cu2+ and Ni2+ to bovine, dog, and human serum albumin has been studied by the 35Cl NMR probe technique. The number of primary copper sites were estimated to be 1.3 for human serum albumin, 3.1 for bovine serum albumin, and 6.6 for dog serum albumin. A similar number of primary nickel sites was determine...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Mohanakrishnan P,Chignell CF,Cox RH

    更新日期:1985-01-01 00:00:00

  • Plant anticancer agents XXXIX: Triterpenes from Iris missouriensis (Iridaceae).

    abstract::Employing the roots of Iris missouriensis, two known triterpenes, iso-iridogermanal and zeorin, were isolated and identified. As presently reported, they were found to demonstrate cytotoxic activity toward cultured P-388 cells (ED50 = 0.1 and 1.1 microgram/mL, respectively). Additionally, a new triterpene that demonst...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wong SM,Oshima Y,Pezzuto JM,Fong HH,Farnsworth NR

    更新日期:1986-03-01 00:00:00

  • Effect of pH on the in vitro dissolution and in vivo absorption of controlled-release theophylline in dogs.

    abstract::Dogs were used to examine the effect of elevated gastric pH on the absorption of controlled-released theophylline dosage forms with pH-dependent dissolution. In vitro studies showed that a controlled-release theophylline tablet dissolved more rapidly if it was initially exposed to an acidic media. In contrast, a contr...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Vashi VI,Meyer MC

    更新日期:1988-09-01 00:00:00

  • Tocainide conjugation in humans: novel biotransformation pathway for a primary amine.

    abstract::The metabolism of tocainide, an experimental antiarrhythmic drug, was studied in humans. Urinary excretion of unchanged drug was 28-55% in 24 hr after oral dosing. Urine hydrolysis with hydrochloric acid or beta-glucuronidase increased tocainide recovery to 55-79%. Saccharo-1,4-lactone inhibited the beta-glucuronidase...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Elvin AT,Keenaghan JB,Byrnes EW,Tenthorey PA,McMaster PD,Takman BH,Lalka D,Manion CV,Baer DT,Wolshin EM,Meyer MB,Ronfeld RA

    更新日期:1980-01-01 00:00:00

  • Metabolism of carprofen, a nonsteroid anti-inflammatory agent, in rats, dogs, and humans.

    abstract::The metabolic disposition of 14C-labeled carprofen [(+/-)-6-chloro-alpha-methylcarbazole-2-acetic acid] was investigated in rats, dogs, and humans. Carprofen is eliminated predominantly by biotransformation in these three species. In dogs and rats, the direct conjugation of carprofen to form an ester glucuronide and o...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Rubio F,Seawall S,Pocelinko R,DeBarbieri B,Benz W,Berger L,Morgan L,Pao J,Williams TH,Koechlin B

    更新日期:1980-11-01 00:00:00

  • Evaluation of the viability of Lactobacillus spp. after the production of different solid dosage forms.

    abstract::The work aims to provide evidence on the viability of Lactobacillus spp. and a spore form of Bacillus subtilis from nonprocessed bacteria to coated dosage forms (i.e., mini-tablets, pellets, and their coated forms). Lactobacillus spp. were cultivated overnight in MRS broth (10(9) cfu/mL) and B. subtilis spores were pr...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Brachkova MI,Duarte A,Pinto JF

    更新日期:2009-09-01 00:00:00

  • Pharmacokinetics of Peptide-Fc fusion proteins.

    abstract::Peptide-Fc fusion proteins (or peptibodies) are chimeric proteins generated by fusing a biologically active peptide with the Fc-domain of immunoglobulin G. In this review, we describe recent studies that have evaluated the absorption, distribution, metabolism, and excretion characteristics of peptibodies. Key features...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Wu B,Sun YN

    更新日期:2014-01-01 00:00:00

  • Protection of bovine serum albumin from aggregation by Tween 80.

    abstract::In an attempt to explain the mechanism of protein stabilization conferred by detergents, we investigated the effect of Tween 80 on aggregation of bovine serum albumin (BSA) using circular dichroism (CD) and native gel electrophoresis. CD thermal scans showed that BSA denatures at about 54 degrees C in 20 mM Tris, pH 7...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Arakawa T,Kita Y

    更新日期:2000-05-01 00:00:00

  • Colorimetric acetaminophen determination in pharmaceutical formulations.

    abstract::Different approaches for the colorimetric determination of acetaminophen, based on its coupling with diazotized o-nitroaniline, are described. Copper(II) chelation with the coupled compound makes the method highly selective. Sensitivity is increased when the acetaminophen assay is carried out indirectly through the de...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Belal S,Elsayed MA,El-Waliely A,Abdine H

    更新日期:1979-06-01 00:00:00

  • Disposition of norgestimate in the presence and absence of ethinyl estradiol after oral administration to humans.

    abstract::The disposition of radioactivity following oral administration of 14C-norgestimate was compared to that following administration of the drug in combination with 3H-ethinyl estradiol in humans. Seven normal, healthy female subjects were each administered one capsule orally containing 14C-norgestimate either alone (74.4...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Weintraub HS,Abrams LS,Patrick JE,McGuire JL

    更新日期:1978-10-01 00:00:00

  • Therapeutic tolerance, hemodynamic effects, and oral dose kinetics of dilazep dihydrochloride in hypertensive patients.

    abstract::The oral dose metabolism of dilazep dihydrochloride [tetrahydro-1H-1,4-diazepine-1,4(5H)-dipropanol 3,4,5-trimethoxybenzoate] was examined in six hypertensive patients receiving a single oral dose of 600 mg of dilazep (3-3.8 mg/kg BW). Blood was collected at 0.5, 1, 1.5, 2, 3, 4, 6, 8, 10, and 24 h after administratio...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sambhi MP,Kannan R,Thananopavarn C,Ookhtens M,Gudenzi M

    更新日期:1989-04-01 00:00:00

  • Tensile strengths and hardness of tablets.

    abstract::The axial and radial tensile strengths were compared to the hardness of compressed tablets containing various concentrations of lubricants. Since radial tensile strength measurement considers the thickness of a tablet, and only tensile stress and axial tensile strength express the strength in the direction in which ca...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Jarosz PJ,Parrott EL

    更新日期:1982-06-01 00:00:00

  • Spectrophotometric determination of hydralazine with 2-hydroxy-1-naphthaldehyde in pharmaceuticals.

    abstract::A new extraction-spectrophotometric method for the determination of hydralazine, based on its reaction with 2-hydroxy-1-naphthaldehyde at 25 degrees C, is described. The calibration curve was linear between 0.4 and 6 mg/mL of hydralazine. The molar absorbtivity of the product at 408 nm is 40,900 The meth...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Mari-Buigues J,Mañes-Vinuesa J,Garcia-Domenech R,Pous-Miralles G

    更新日期:1991-07-01 00:00:00

  • Modeling of transmitted X-ray intensity variation with sample thickness and solid fraction in glycine compacts.

    abstract::The previous paper in this series introduced an X-ray diffraction quantitation method for the polymorphic content in tablets made of pure components. Before the method could be transferred, further studies were required to explain the commonly observed X-ray intensity variation in analyzing compacts. The literature ty...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cao W,Mullarney MP,Hancock BC,Bates S,Morris KR

    更新日期:2003-12-01 00:00:00

  • Development and characterization of a novel, antimicrobial, sterile hydrogel dressing for burn wounds: single-step production with gamma irradiation creates silver nanoparticles and radical polymerization.

    abstract::Patients with burn wounds are susceptible to wound infection and sepsis. This research introduces a novel burn wound dressing that contains silver nanoparticles (SNPs) to treat infection in a 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS-Na(+) ) hydrogel. Silver nitrate was dissolved in AMPS-Na(+) solut...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Boonkaew B,Barber PM,Rengpipat S,Supaphol P,Kempf M,He J,John VT,Cuttle L

    更新日期:2014-10-01 00:00:00