Abstract:
:A new mucoadhesive tablet, which releases natural active agents for pain reduction and rapid healing of canker sores, has been prepared and characterized. Adhesive tablets were prepared by compression molding of mixed powders of crosslinked polyacrylic acid and hydroxypropyl cellulose, absorbed with citrus oil and magnesium salt. The rate of tablet erosion and the rates of citrus oil and magnesium release were determined as well as the adhesiveness of the tablet using bovine gingival tissue and an Instron tensiometer. A clinical trial was conducted on 248 volunteers who had canker sores. Tablets adhere well to the mucosal tissue and gradually erode for 8 h releasing the citrus oil in a zero-order pattern whereas the magnesium is released during a period of 2 h. Both experimental and plain tablets were effective in reducing pain and decreasing healing time (p < 0.05) without adverse side effects. However, the tablets loaded with active agents were more effective.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Mizrahi B,Golenser J,Wolnerman JS,Domb AJdoi
10.1002/jps.20193subject
Has Abstractpub_date
2004-12-01 00:00:00pages
2927-35issue
12eissn
0022-3549issn
1520-6017pii
S0022-3549(16)39320-0journal_volume
93pub_type
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