Abstract:
:Topical lidocaine has been recently marketed as a new treatment for post-herpetic neuralgia. The aim of our study was to characterize the absorption profile of and systemic exposure to lidocaine from patch and gel formulations in normal volunteers, patients with post-herpetic neuralgia, and patients with acute herpes zoster. The bioavailability of lidocaine from the patch formulation averaged 3%, and was similar after single and repeated doses. Systemic exposure to lidocaine and monoethylglycinexylidide (MEGX), the primary active metabolite of lidocaine, after application of lidocaine gel or patches was minimal in normal volunteers, patients with post-herpetic neuralgia, and patients with acute herpes zoster. Considering the benefit versus risk of topical lidocaine, systemic absorption and toxicity of lidocaine seems not to be a significant risk.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Campbell BJ,Rowbotham M,Davies PS,Jacob P 3rd,Benowitz NLdoi
10.1002/jps.10133subject
Has Abstractpub_date
2002-05-01 00:00:00pages
1343-50issue
5eissn
0022-3549issn
1520-6017pii
S0022-3549(16)30997-2journal_volume
91pub_type
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