当前位置： SCI文献检索 > JOURNAL OF PHARMACEUTICAL SCIENCES期刊下所有文献 > Effects of organic anions on the uptake of 1-anilino-8-naphthalenesulfonate by isolated liver cells.

Effects of organic anions on the uptake of 1-anilino-8-naphthalenesulfonate by isolated liver cells.

Abstract：

:Uptake of the fluorescent probe, 1-anilino-8-naphthalene-sulfonate (I) into isolated rat liver cells was studied using both fluorescence and filtration methods. The time course of the fluorescence enhancement of I after addition to the isolated liver cells was analyzed in terms of rapid, medium, and slow phases. The slow phase (half-time approximately 7 min) was characteristic of viable cells. The fluorescence enhancement was proportional to the amount of I taken into the cells, as measured by the filtration method. The uptake of I followed Michaelis-Menten kinetics with an apparent Km of 39 microM and Vmax of 1.4 nmole/10(6) cells/min. The temperature coefficient (Q10) of the uptake of I was found to be approximately 1.9. No pH optimum was observed, and various metabolic inhibitors did not affect the uptake of I. Among the amino acid reagents used, only 2,4-dinitrofluorobenzene decreased the uptake of I (by approximately 45%). The effects of various organic anions on the uptake of I were measured. The inhibition of the uptake of I by sulfobromophthalein could be analyzed in terms of competitive inhibition; the slight inhibition by sodium taurocholate could not. It is concluded that the uptake of I is a carrier-mediated facilitated process, and that the carrier is common to both I and sulfobromophthalein.

journal_name

J Pharm Sci

journal_title

Journal of pharmaceutical sciences

authors

Sugiyama Y,Kimura S,Lin JH,Izukura M,Awazu S,Hanano M

doi

10.1002/jps.2600720809

subject

Has Abstract

pub_date

1983-08-01 00:00:00

pages

871-6

issue

8

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)44712-4

journal_volume

72

pub_type

杂志文章

相关文献

JOURNAL OF PHARMACEUTICAL SCIENCES文献大全
  • Application of central composite designs to the preparation of polycaprolactone nanoparticles by solvent displacement.

    abstract：:Cyclosporin A (CyA) is a good candidate for incorporation in colloidal carriers such as nanoparticles (NP) that would diminish the adverse effects associated with its use under conventional pharmaceutical dosage forms and improve bioavailability after oral administration. In this study a composite rotational experimen...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1021/js950164r

    authors： Molpeceres J,Guzman M,Aberturas MR,Chacon M,Berges L

    更新日期：1996-02-01 00:00:00

  • Fetal and maternal placental and nonplacental clearances of metoclopramide in chronically instrumented pregnant sheep.

    abstract：:The placental and nonplacental clearances of metoclopramide were studied in nine chronically instrumented, near-term pregnant sheep using a two-compartment open model. Metoclopramide was administered to the ewe and fetus on separate occasions as an initial iv bolus loading dose followed by a constant-rate infusion, wi...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600791204

    authors： Riggs KW,Rurak DW,Taylor SM,McErlane BA,McMorland GH,Axelson JE

    更新日期：1990-12-01 00:00:00

  • Measurement of dissociation constants (pKa values) of organic compounds by multiplexed capillary electrophoresis using aqueous and cosolvent buffers.

    abstract：:Evaluation of a multiplexed capillary electrophoresis (CE) method for pK(a) measurements of organic compounds, including low solubility compounds, is presented. The method is validated on a set of 105 diverse compounds, mostly drugs, and results are compared to literature values obtained from multiple references. Two ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.21287

    authors： Shalaeva M,Kenseth J,Lombardo F,Bastin A

    更新日期：2008-07-01 00:00:00

  • Effect of low molecular weight chitosans on drug permeation through mouse skin: 1. Transdermal delivery of baicalin.

    abstract：:The aim of this work was to evaluate the low molecular weight chitosans (LMWCs) as enhancers of transdermal administration of baicalin, an useful drug for the treatment of atopic dermatitis, viral hepatitis, and HIV infection. Permeation experiments were performed in vitro through mouse skin by using Franz cells. Impr...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.22063

    authors： Zhou X,Liu D,Liu H,Yang Q,Yao K,Wang X,Wang L,Yang X

    更新日期：2010-07-01 00:00:00

  • Phenylpropanolamine potentiates caffeine neurotoxicity in rats.

    abstract：:Numerous case reports have documented that phenylpropanolamine (PPA) stimulates the central nervous system with symptoms ranging from anxiety and hallucinations to grand mal seizures produced by overdoses. Most of these reports have occurred following concomitant use of caffeine which in high doses is known to cause s...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600781203

    authors： Walker JS

    更新日期：1989-12-01 00:00:00

  • Determination of nofedone in human serum by electron-capture GLC.

    abstract：:An electron-capture GLC method to measure nofedone in human serum was developed. A homolog of nofedone was added to the serum as an internal standard before the sample was alkalinized with pH 9.5 phosphate buffer and extracted with ethylene dichloride containing 0.5% isopentyl alcohol. This organic phase was extracted...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600690307

    authors： Heusse D,Populaire P,Renard A,Pasquier P,Gregoire J

    更新日期：1980-05-01 00:00:00

  • Desethylaprophen: a metabolite of aprophen with antimuscarinic activities.

    abstract：:The metabolic fate of aprophen hydrochloride (2-diethylaminoethyl 2,2-diphenylpropionate) was studied in rats after intravenous administration. Both 14C-labeled and unlabeled aprophen were used in these studies. Blood samples were collected and analyzed to determine the identities of the metabolites formed. Utilizing ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600770210

    authors： Brown ND,Smejkal RM,Breuer E,Doctor BP,Chiang PK

    更新日期：1988-02-01 00:00:00

  • Synthesis and irreversible beta-adrenergic blockade with a bromoacetamido derivative of betaxolol.

    abstract：:1-[4-(2-Cyclopropylmethoxyethyl)phenoxy]-3-[1-p-(bromoacetamidophe nyl) -2-methyl-2-propylamine]-2-propranol (8), which is a derivative of the beta 1-adrenergic agent betaxolol, was synthesized. Compound 8 showed less potent beta-adrenergic blocking activity than betaxolol in an in vitro test with guinea pig tracheal ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600741024

    authors： Amlaiky N,Leclerc G

    更新日期：1985-10-01 00:00:00

  • Synthesis, physicochemical parameters, and in vitro evaluation of N1-p-chlorophenyl-N5-alkylbiguanides.

    abstract：:A series of N1-p-chlorophenyl-N5-alkylbiguanides were synthesized as potential inhibitors of dental plaque. Partition coefficients and pKa values were determined by standard methods. Biological activity was evaluated against Streptococcus mutans, a pure strain of plaque-forming bacteria. All compounds were compared to...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600650731

    authors： Warner VD,Lynch DM,Ajemian RS

    更新日期：1976-07-01 00:00:00

  • Colorimetric determination of nadolol in tablets.

    abstract：:Nadolol was extracted from tablet excipients with an acidic potassium chloride solution. The drug was oxidized with periodic acid, and the resulting aldehyde was reacted with 2,4-dinitrophenylhydrazine to form the corresponding hydrazone. Excess reagent was removed with a cupric chloride solution. The hydrazone was ex...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600670743

    authors： Ivashikiv E

    更新日期：1978-07-01 00:00:00

  • Species difference in GI motor response to somatostatin.

    abstract：:Acute experiments were performed on overnight fasted chloralose-urethan anesthetized dogs, cats, rabbits, and rats. Under these conditions, somatostatin practically abolished gastric contractions and decreased GI tonus in all species examined. The canine duodenum, jejunum, and ileum exhibited only a contractile respon...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600680913

    authors： Tansy MF,Martin JS,Landin WE,Kendall FM

    更新日期：1979-09-01 00:00:00

  • Protein adsorption, desorption, and aggregation mediated by solid-liquid interfaces.

    abstract：:Adsorption of proteins to solid-fluid interfaces is often empirically found to promote formation of soluble aggregates and larger, subvisible, and visible particles, but key stages in this process are often difficult to probe directly. Aggregation mediated by adsorption to water-silicon oxide (SiOx) interfaces, akin t...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.24429

    authors： Perevozchikova T,Nanda H,Nesta DP,Roberts CJ

    更新日期：2015-06-01 00:00:00

  • Application of X-Ray Sensors for In-line and Noninvasive Monitoring of Mass Flow Rate in Continuous Tablet Manufacturing.

    abstract：:The progress in continuous downstream manufacturing of oral solid doses demands effective real-time process management, with monitoring at its core. This study evaluates the feasibility of using a commercial sensor to measure the mass flow rate of the particulates, a critical process variable in continuous manufacturi...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1016/j.xphs.2017.08.019

    authors： Ganesh S,Troscinski R,Schmall N,Lim J,Nagy Z,Reklaitis G

    更新日期：2017-12-01 00:00:00

  • α-Lipoic Acid in Soluplus(®) Polymeric Nanomicelles for Ocular Treatment of Diabetes-Associated Corneal Diseases.

    abstract：:α-Lipoic acid (ALA) is a powerful antioxidant valuable for prevention and treatment of ophthalmic complications such as diabetic keratopathy and retinopathy. The aim of this work was to develop micelle-based formulations that can enhance the solubility, stability, and corneal permeability of ALA. Compared to a convent...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1016/j.xphs.2016.03.006

    authors： Alvarez-Rivera F,Fernández-Villanueva D,Concheiro A,Alvarez-Lorenzo C

    更新日期：2016-09-01 00:00:00

  • Freezing of Biologicals Revisited: Scale, Stability, Excipients, and Degradation Stresses.

    abstract：:Although many biotech products are successfully stored in the frozen state, there are cases of degradation of biologicals during freeze storage. These examples are discussed in the Perspective to emphasize the fact that stability of frozen biologicals should not be taken for granted. Frozen-state degradation (predomin...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.xphs.2019.10.062

    authors： Authelin JR,Rodrigues MA,Tchessalov S,Singh SK,McCoy T,Wang S,Shalaev E

    更新日期：2020-01-01 00:00:00

  • Impact of recovery on fraction unbound using equilibrium dialysis.

    abstract：:Historically, recovery had been used to evaluate the data quality of plasma protein binding or tissue binding obtained from equilibrium dialysis assays. Low recovery was often indicative of high nonspecific binding, instability, or low solubility. This study showed that, when equilibrium was fully established in the d...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.23013

    authors： Di L,Umland JP,Trapa PE,Maurer TS

    更新日期：2012-03-01 00:00:00

  • Feasibility of atomic force microscopy for determining crystal growth rates of nifedipine at the surface of amorphous solids with and without polymers.

    abstract：:Amorphous nifedipine (NFD), which has a smooth surface immediately after preparation, was shown to have structures resembling clusters of curling and branching fibers approximately 1 μm wide by atomic force microscopy (AFM) after storage at 25°C. The size of the cluster-like structures increased with storage over time...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.22603

    authors： Miyazaki T,Aso Y,Kawanishi T

    更新日期：2011-10-01 00:00:00

  • Highly accurate nephelometric titrimetry.

    abstract：:A method that accurately indicates the end-point of precipitation reactions by the measurement of the relative intensity of the scattered light in the titrate is presented. A new nephelometric titrator with an internal nephelometric sensor has been devised. The work of the titrator including the sensor and change in t...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.10548

    authors： Zhan X,Li C,Li Z,Yang X,Zhong S,Yi T

    更新日期：2004-02-01 00:00:00

  • Diffusion model for fluidized-bed drying.

    abstract：:A sucrose-lactose-starch granulation was used to study particulate motion and attrition in a fluid bed dryer. There is some classification of material in the dryer as drying proceeds; fine particles are dried faster and become less dense, and the less dry but denser large particles show some (although not great) accum...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600641127

    authors： Zoglio MA,Streng WH,Carstensen JT

    更新日期：1975-11-01 00:00:00

  • Design of Block Copolymer Costabilized Nonionic Microemulsions and Their In Vitro and In Vivo Assessment as Carriers for Sustained Regional Delivery of Ibuprofen via Topical Administration.

    abstract：:Nonionic surfactants (caprylocaproyl macrogol-8 glycerides, octoxynol-12, polysorbate-20, and polyethylene glycol-40 hydrogenated castor oil) (47.03%, w/w), costabilizer (poloxamer 407) (12%-20%, w/w), oil (isopropyl myristate) (5.22%, w/w), water (q.s. ad 100%, w/w), and ibuprofen (5%, w/w) were used to develop oil-i...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.24494

    authors： Djekic L,Martinovic M,Stepanović-Petrović R,Tomić M,Micov A,Primorac M

    更新日期：2015-08-01 00:00:00

  • Enhancing the Pharmaceutical Behavior of Nateglinide by Cocrystallization: Physicochemical Assessment of Cocrystal Formation and Informed Use of Differential Scanning Calorimetry for Its Quantitative Characterization.

    abstract：:The aim of this study was to synthetize cocrystals of nateglinide, an antidiabetic agent of biopharmaceutics classification system Class IIa, as a strategy to improve both the solubility and the dissolution rate of the drug. Benzamide was selected by a screening procedure as a suitable coformer, and binary mixtures wi...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1016/j.xphs.2018.11.033

    authors： Bruni G,Maggi L,Mustarelli P,Sakaj M,Friuli V,Ferrara C,Berbenni V,Girella A,Milanese C,Marini A

    更新日期：2019-04-01 00:00:00

  • Development of aqueous parenteral formulations for carbamazepine through the use of modified cyclodextrins.

    abstract：:The poor aqueous solubility of carbamazepine was dramatically increased via complexation with various chemically modified beta-cyclodextrins and gamma-cyclodextrins. A preparation of carbamazepine and 2-hydroxypropyl-beta-cyclodextrin was found to be stable to steam sterilization and to storage under a variety of cond...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600800420

    authors： Brewster ME,Anderson WR,Estes KS,Bodor N

    更新日期：1991-04-01 00:00:00

  • The Use of Binary Polymeric Networks in Stabilizing Polyethylene Oxide Solid Dispersions.

    abstract：:The objective of this study was to determine if a high Tg polymer (Eudragit(®) S100) could be used to stabilize amorphous domains of polyethylene oxide (PEO) and hence improve the stability of binary polymer systems containing celecoxib (CX). We propose a novel method of stabilizing the amorphous PEO solid dispersion ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1016/j.xphs.2016.06.004

    authors： Jones DS,Tian Y,Li S,Yu T,Abu-Diak OA,Andrews GP

    更新日期：2016-10-01 00:00:00

  • Methionine, tryptophan, and histidine oxidation in a model protein, PTH: mechanisms and stabilization.

    abstract：:Recent oxidation events on monoclonal antibody candidates prompted us to investigate the mechanism of oxidation of Met, Trp, and His residues and to search for suitable stabilizers. By using parathyroid hormone (1-34), PTH, as a model protein and various oxidants, aided by liquid chromatography, peptide mapping, and m...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.21746

    authors： Ji JA,Zhang B,Cheng W,Wang YJ

    更新日期：2009-12-01 00:00:00

  • Calorimetric determination of the heat of precipitation of pseudoephedrine racemic compound--its agreement with the heat of solution.

    abstract：:The heat of precipitation of dl-pseudoephedrine was determined by direct calorimetry using a Tronac isoperibolic calorimeter. The precipitation of dl-pseudoephedrine was induced by mixing aqueous solutions of the two enantiomers, namely, d- and l-pseudoephedrine, directly in the calorimeter. The molar heat of precipit...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600841017

    authors： Pudipeddi M,Sokoloski TD,Duddu SP,Carstensen JT

    更新日期：1995-10-01 00:00:00

  • Prevention of molecular self-association by sodium salicylate: effect on methylene blue.

    abstract：:Sodium salicylate improves the rectal absorption of drugs which exhibit molecular self-association; it is suggested that salicylate may improve drug bioavailability by altering the drug self-association pattern. Methylene blue was chosen as a model molecule for investigating the interference of salicylate with drugs u...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600750413

    authors： Touitou E,Fisher P

    更新日期：1986-04-01 00:00:00

  • In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil.

    abstract：:The objective of this study was to investigate the permeation-enhancing effect of thiolated polycarbophil (PCP) on peptide drugs. Mediated by a carbodiimide, increasing amounts of cysteine (Cys) were covalently bound to sodium neutralized PCP (NaPCP). The extent of covalently attached Cys was determined by quantifying...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/1520-6017(200010)89:10<1253::aid-jps3>3.0.

    authors： Clausen AE,Bernkop-Schnürch A

    更新日期：2000-10-01 00:00:00

  • In vitro binding of chloroquine to rat muscle preparations.

    abstract：:Chloroquine (7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline; CQ) accumulates in the insoluble fraction of rat muscle homogenates with an equilibrium distribution ratio of 7.8 L/kg. This is of a similar magnitude to muscle:plasma ratios observed in vivo. Uptake is approximately linear, even up to concentra...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600751109

    authors： MacIntyre AC,Cutler DJ

    更新日期：1986-11-01 00:00:00

  • High-performance liquid chromatographic determination of propranolol and 4-hydroxypropranolol in plasma.

    abstract：:A high-performance liquid chromatographic method for the simultaneous determination of propranolol and 4-hydroxypropranolol in plasma is presented. The method involves plasma extraction at basic pH with ethyl column, and fluorescence detection. The within-run a reversed-phase column coefficient of variation were 3.0-7...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600700631

    authors： Rosseel MT,Bogaert MG

    更新日期：1981-06-01 00:00:00

  • Prediction of the association state of insulin using spectral parameters.

    abstract：:Human insulin exists in different association states, from monomer to hexamer, depending on the conditions. In the presence of zinc the "normal" state is a hexamer. The structural properties of 20 variants of human insulin were studied by near-UV circular dichroism, fluorescence spectroscopy, and small-angle X-ray sca...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.10355

    authors： Uversky VN,Garriques LN,Millett IS,Frokjaer S,Brange J,Doniach S,Fink AL

    更新日期：2003-04-01 00:00:00