Abstract：
:The free radical scavenger properties of vitamin E (DL-alpha-tocopherol), a natural antioxidant, and derivatives were studied using an original in vitro method consisting of free radical production by photoirradiation of pheomelanin and direct detection of the free radicals by a physical, specific technique, electron spin resonance. Validation of this method has been realized using well-known biological free radical scavengers, superoxide dismutase and reduced glutathione. DL-alpha-Tocopherol, tocopheryl acetate, tocopheryl linoleate, and tocopheryl polyoxyethylene (POE) succinate induced a significant diminution of the free radical production. In order of efficiency, tocopheryl POE succinate was the best scavenger (37.6% inhibition at 0.25%) followed by tocopheryl linoleate (25.6% inhibition at 1%) and tocopheryl acetate (23.9% inhibition at 0.5%) and finally DL-alpha-tocopherol (16.2% inhibition at 0.05%). The results reported a decrease of the inhibitory effect for high concentrations of DL-alpha-tocopherol (0.1%) and tocopheryl acetate (1%), showing a tendency of this compound to act as a prooxidant. Used in optimal concentrations in cosmetologic or dermatologic formulations, Vitamin E and these derivatives should prevent or reduce the harmful activity of free radicals in the skin.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Duval C,Poelman MCdoi
10.1002/jps.2600840124subject
Has Abstractpub_date
1995-01-01 00:00:00pages
107-10issue
1eissn
0022-3549issn
1520-6017pii
S0022-3549(15)49678-9journal_volume
84pub_type
杂志文章abstract：:Hexamidine isethionate in various pharmaceutical formulations was analyzed quantitatively by high-performance liquid chromatography. The method is rapid, accurate, and precise. Excellent results were obtained from four commercial bases. ...
journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600721229
更新日期：1983-12-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600700722
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abstract：:A general spectroscopic method is described that might be applied to validating amino acid sequences in peptides and protein fragments with a view to it becoming a routine procedure with which to characterize biotechnology drug products. The tripeptides are the L-enantiomers of GGA, GGH, GGI, GGL, GGF, GHG, LGG, and Y...
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doi：10.1002/jps.22720
更新日期：2011-12-01 00:00:00
abstract：:Solvent-induced 3 frameworks (the monohydrate, methanol solvate, and dimethyl formamide [DMF] solvate) of an anticancer drug, 7-ethyl-10-hydroxycamptothecin (SN38), were constructed. The crystal structures of the 3 pseudopolymorphs were characterized by single-crystal X-ray diffraction technique for the first time. Cr...
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doi：10.1002/jps.20237
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journal_title：Journal of pharmaceutical sciences
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更新日期：1994-01-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：1976-01-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600790107
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doi：10.1002/jps.2600641026
更新日期：1975-10-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600700906
更新日期：1981-09-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.23884
更新日期：2014-04-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600810514
更新日期：1992-05-01 00:00:00
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doi：10.1002/jps.22082
更新日期：2010-07-01 00:00:00
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doi：10.1002/jps.23554
更新日期：2013-06-01 00:00:00
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更新日期：1985-03-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600710812
更新日期：1982-08-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600770106
更新日期：1988-01-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600840225
更新日期：1995-02-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600800912
更新日期：1991-09-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：1990-08-01 00:00:00
abstract：:A simple, reliable, and user friendly system was established to cultivate Caco-2 cell monolayer for epithelial transport studies. After an initial growth period of 1 week in a CO(2) incubator, Caco-2 cells were cultivated in an automated continuous perfusion system (Minucells and Minutissue, Germany). Medium was const...
journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.20149
更新日期：2004-10-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600730410
更新日期：1984-04-01 00:00:00
