Abstract:
:The phase diagram for the binary system nafcillin sodium-water, was determined using differential scanning calorimetry (DSC) and polarized light microscopy. In the temperature range of -20-30 degrees, three crystalline forms and an amphiphilic liquid crystalline phase were detected. The stable crystalline form of nafcillin sodium (form alpha) and water exhibit a eutectic mixture containing 28% drug (w/w) at -1 degrees. In more dilute solutions a lower temperature eutectic (-5 degrees) occurs. The composition and form of nafcillin sodium in this eutectic are not known. The form -5 degrees eutectic was found to be metastable above 28% concentration and converted to form alpha. Two other crystalline forms were observed at 9 degrees (form beta) and 22 degrees (form gamma) at concentrations above 40%. The crystalline forms could not be further characterized due to their transient nature and existence in highly concentrated mixtures. A lamellar mesophase is present near ambient temperature in mixtures containing more than 55% nafcillin sodium. The phase equilibria were highly susceptible to supercooling. Temperature cycling methods were devised which gave reproducible DSC data and allowed construction of the phase diagram.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Bogardus JBdoi
10.1002/jps.2600710125subject
Has Abstractpub_date
1982-01-01 00:00:00pages
105-9issue
1eissn
0022-3549issn
1520-6017pii
S0022-3549(15)43988-7journal_volume
71pub_type
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