Abstract：
:It was reported that wax matrix (WM) particles composed of low-melting-point microcrystalline wax showed unique release behaviors; the particles released only a small amount of the entrapped drug (non-diffusion-controlled release) at 37°C, whereas it showed comparatively fast drug release in a diffusion-controlled manner at 25°C. However, the mechanism of the drug release is still unclear. The objective of this study was to determine the mechanism of drug release from the WM particles using X-ray computed tomography. In the WM particles collected during dissolution tests at 25°C, the void space derived from drug release increased with increasing time, and there was no change in the structure, indicating that the WM particles released drug while maintaining the particle shape at 25°C. In the WM particles collected during dissolution tests at 37°C, the void space was confirmed at initial time point; however, at subsequent time points, the void space was disappeared, and the roughness of the surface was evident. This structural change may have blocked the conveyance pathway of the outer medium, which would inhibit the drug release. The difference between the drug-release mechanisms of the WM particles at the 2 temperatures will be valuable for developing cooling-triggered, temperature-sensitive formulations.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Matsumoto K,Kimura SI,Noguchi S,Itai S,Kondo H,Iwao Ydoi
10.1016/j.xphs.2019.01.010subject
Has Abstractpub_date
2019-06-01 00:00:00pages
2086-2093issue
6eissn
0022-3549issn
1520-6017pii
S0022-3549(19)30018-8journal_volume
108pub_type
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