Perforated coated tablets for controlled release of drugs at a constant rate.

Abstract:

:Tablets with a central hole and a water-impermeable coating were prepared. These perforated coated tablets (PCTs) dissolve and release drug through the central hole only. In vitro release of the model drugs sodium benzoate and benzamide from PCTs occurred at a constant rate up to 80% release. The zero-order release rate varies with hole size, drug solubility, drug concentration, diluent solubility, and binder concentration. These results demonstrate that the PCT design can be used to prepare drug delivery devices which release at controllable constant rates.

journal_name

J Pharm Sci

authors

Hansson AG,Giardino A,Cardinal JR,Curatolo W

doi

10.1002/jps.2600770408

subject

Has Abstract

pub_date

1988-04-01 00:00:00

pages

322-4

issue

4

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)47664-6

journal_volume

77

pub_type

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