Abstract:
:Tablets with a central hole and a water-impermeable coating were prepared. These perforated coated tablets (PCTs) dissolve and release drug through the central hole only. In vitro release of the model drugs sodium benzoate and benzamide from PCTs occurred at a constant rate up to 80% release. The zero-order release rate varies with hole size, drug solubility, drug concentration, diluent solubility, and binder concentration. These results demonstrate that the PCT design can be used to prepare drug delivery devices which release at controllable constant rates.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Hansson AG,Giardino A,Cardinal JR,Curatolo Wdoi
10.1002/jps.2600770408subject
Has Abstractpub_date
1988-04-01 00:00:00pages
322-4issue
4eissn
0022-3549issn
1520-6017pii
S0022-3549(15)47664-6journal_volume
77pub_type
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journal_title:Journal of pharmaceutical sciences
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