Abstract:
:A high-performance liquid chromatographic method has been developed for the simultaneous determination of azobenzene and hydrazobenzene in phenylbutazone and sulfinpyrazone raw materials and formulations. The drug raw material or formulation is shaken with 1N NaOH and n-hexane and centrifuged. The n-hexane layer is injected into a chromatograph equipped with a 10-micron cyano-amino bonded phase column. Azobenzene and hydrazobenzene are detected at 313 and 254 nm, respectively; the sensitivities are approximately 1 and 2 ppm, respectively, in the raw materials and formulations.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Matsui F,Lovering EG,Curran NM,Watson JRdoi
10.1002/jps.2600721032subject
Has Abstractpub_date
1983-10-01 00:00:00pages
1223-4issue
10eissn
0022-3549issn
1520-6017pii
S0022-3549(15)44802-6journal_volume
72pub_type
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