Abstract：
:The tablet friability resulting from formulation variations was studied under controlled granulation moisture content and tablet crushing strength. Tablets made with lactose were more friable than tablets made with microcrystalline cellulose. Replacement of 0.5% magnesium stearate with 0.5% stearic acid in the formula reduced tablet friability, whereas the combination of 0.5% stearic acid and up to 0.25% magnesium stearate did not increase tablet friability, decrease drug dissolution rate, or increase tablet-to-tablet variability in dissolution. Tablets compressed with extra deep concave punches resulted in lower friability compared with tablets compressed with standard concave or deep concave punches. The friabilities of the standard convex and deep convex tablets were similar, indicating that a critical level of punch tip curvature was important in reducing tablet friability. The dissolution rate was not affected by the punch tip geometry, but the tablet-to-tablet dissolution variability at the 0.5% stearic acid level for the extra deep convex tablets was higher compared with the standard convex tablets.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Chowhan ZT,Amaro AA,Ong JTdoi
10.1002/jps.2600810320subject
Has Abstractpub_date
1992-03-01 00:00:00pages
290-4issue
3eissn
0022-3549issn
1520-6017pii
S0022-3549(15)48792-1journal_volume
81pub_type
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journal_title：Journal of pharmaceutical sciences
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