Abstract:
:The estimation of aqueous solubilities of organic nonelectrolytes by the General Solubility Equation (GSE) as proposed by Valvani and Yalkowsky (1980) is used in this study. The data and assumptions on which the GSE are based are reevaluated, and the equation is revised. The revised GSE is validated on a set of 580 pharmaceutically, environmentally, and industrially relevant nonelectrolytes. The revised equation has a stronger theoretical background and provides a more accurate estimation of aqueous solubility.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Jain N,Yalkowsky SHdoi
10.1002/1520-6017(200102)90:2<234::aid-jps14>3.0.csubject
Has Abstractpub_date
2001-02-01 00:00:00pages
234-52issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(16)30715-8journal_volume
90pub_type
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