Noninvasive identification of materials inside USP vials with Raman spectroscopy and a Raman spectral library.


:A commercial dispersive Raman spectrometer operating at 785 nm with a CCD detector was used to acquire spectra of USP reference materials inside amber USP vials. The laser and collection beams were directed through the bottom of the vials, resulting in a 60% loss of signal. The Raman shift was calibrated with a 4-acetamidophenol standard, and spectral response was corrected with a luminescent standard. After these corrections, the Raman spectra obtained inside the USP vial and on open powders differed by less than 5%. A spectral library of 309 reference materials was constructed, with spectral acquisition times ranging from 1 to 60 s. Of these, 8% had significant fluorescent background but observable Raman features, while 3% showed only fluorescence. A blind test of 26 unknowns revealed the accuracy of the library search to be 88-96%, depending on search algorithm, and 100% if operator discretion was permitted. The tolerance of the library search to degraded signal-to-noise ratio, resolution, and Raman shift accuracy were tested, and the search was very robust. The results demonstrate that Raman spectroscopy provides a rapid, noninvasive technique for compound identification.


J Pharm Sci


McCreery RL,Horn AJ,Spencer J,Jefferson E




Has Abstract


1998-01-01 00:00:00














  • Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds.

    abstract::The challenge of defining the concentration of unbound drug at the lung target site after inhalation limits the possibility to optimize target exposure by compound design. In this study, a novel rat lung slice methodology has been developed and applied to study drug uptake in lung tissue, and the mechanisms by which t...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bäckström E,Lundqvist A,Boger E,Svanberg P,Ewing P,Hammarlund-Udenaes M,Fridén M

    更新日期:2016-02-01 00:00:00

  • Diphenhydramine disposition in the sheep maternal-placental-fetal unit: determinants of plasma drug concentrations in the mother and the fetus.

    abstract::The objective of this study was to identify the important factors that determine plasma concentrations of diphenhydramine (DPHM) in the mother and the fetus after maternal as well as fetal steady-state drug administration. Inter-relationships were evaluated between maternal and fetal placental and nonplacental clearan...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kumar S,Tonn GR,Riggs KW,Rurak DW

    更新日期:1999-12-01 00:00:00

  • Determination of free bile acids in pharmaceutical preparations by packed column supercritical fluid chromatography.

    abstract::A method was developed for the baseline separation of common free bile acids by supercritical fluid chromatography. A phenylbonded silica column, with UV detection at 210 nm, and carbon dioxide modified with methanol as the mobile phase were used. The influence of the stationary phase, modifier concentration, temperat...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Scalia S,Games DE

    更新日期:1993-01-01 00:00:00

  • Inhibitory effect of valsartan on the intestinal absorption and renal excretion of bestatin in rats.

    abstract::Peptidomimetic drugs have favorable bioavailability owing to H(+)/peptide transporter 1 (PEPT1) located in the intestine. Sartans are commonly used and likely coadministered with peptidomimetic drugs in the clinic; however, in vivo interactions between sartans and peptidomimetic drugs have not been systemically unders...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Huo X,Liu Q,Wang C,Meng Q,Sun H,Peng J,Ma X,Sun P,Liu K

    更新日期:2014-02-01 00:00:00

  • Excipients for Room Temperature Stable Freeze-Dried Monoclonal Antibody Formulations.

    abstract::Sucrose is a common cryoprotectant and lyoprotectant to stabilize labile biopharmaceuticals during freeze-drying and storage. Sucrose-based formulations require low primary drying temperatures to avoid collapse and monoclonal antibody (mAb) containing products need to be stored refrigerated. The objective of this stud...

    journal_title:Journal of pharmaceutical sciences

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    authors: Haeuser C,Goldbach P,Huwyler J,Friess W,Allmendinger A

    更新日期:2020-01-01 00:00:00

  • Stress Temperature Studies in Small Scale Hastelloy® Drug Substance Containers Lead to Increased Extent of and Increased Variability in Antibody-Drug Conjugate and Monoclonal Antibody Aggregation: Evidence for Novel Oxidation-Induced Crosslinking in Monoc

    abstract::Health authorities require that suitable stability of the drug substance be shown in relevant materials of construction. ICH Q1A(R2) explicitly states that "stability studies should be conducted on drug substance packaged in a container closure system that is the same as or simulates the packaging proposed for storage...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Klair N,Kim MT,Lee A,Xiao NJ,Patel AR

    更新日期:2020-10-07 00:00:00

  • Differential thermal, solubility, and aging studies on various sources of digoxin and digitoxin powder: biopharmaceutical implications.

    abstract::Unlike most organic compounds, both digoxin and digitoxin melted over a wide temperature range, with the widest range being 88 and 33 degrees for both compounds, respectively. Furthermore, the melting ranges varied markedly among several untriturated powders obtained from commercial sources and after recrystallization...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chiou WL,Kyle LE

    更新日期:1979-10-01 00:00:00

  • Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Enalapril.

    abstract::Literature data relevant to the decision to allow a waiver of in vivo bioequivalence testing for the marketing authorization of immediate-release, solid oral dosage forms containing enalapril maleate are reviewed. Enalapril, a prodrug, is hydrolyzed by carboxylesterases to the active angiotensin-converting enzyme inhi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Verbeeck RK,Kanfer I,Löbenberg R,Abrahamsson B,Cristofoletti R,Groot DW,Langguth P,Polli JE,Parr A,Shah VP,Mehta M,Dressman JB

    更新日期:2017-08-01 00:00:00

  • Decomposition of alpha-hydroxyaryl ketones and characterization of some unusual products.

    abstract::Alpha-Hydroxyaryl ketones such as 2-hydroxypropiophenone and 1-(2,4-difluorophenyl)-2-hydroxy-1-propanone, the key intermediates in the preparation of antifungal agents, decompose into oxidized, rearranged, and condensed products. These products were isolated and characterized. The possible mechanisms for the formatio...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Gala D,Puar MS,Das PR,Kugelman M,DiBenedetto DJ

    更新日期:1992-12-01 00:00:00

  • Relating Protein-Protein Interactions and Aggregation Rates From Low to High Concentrations.

    abstract::At low protein concentrations (c2), non-native protein aggregation rates are known to be sensitive to changes in conformational stability and "weak" or "colloidal" protein-protein interactions. Protein-protein interactions are also known to be strong functions of c2. In the present work, protein-protein interactions a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ghosh R,Calero-Rubio C,Saluja A,Roberts CJ

    更新日期:2016-03-01 00:00:00

  • Progestin permeation through polymer membrane V: Progesterone release from monolithic hydrogel devices.

    abstract::Progesterone release from monolithic devices prepared from various copolymers of poly(hydroxyethyl methacrylate) and poly(methoxyethoxyethyl methacrylate) or poly(methoxyethyl methacrylate) was examined. In general, plots of the fraction of drug released versus (time)1/2 were linear during the early stages of drug rel...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Song SZ,Cardinal JR,Kim SH,Kim SW

    更新日期:1981-02-01 00:00:00

  • Polymeric drug delivery of platinum-based anticancer agents.

    abstract::Platinum-based anticancer agents such as cisplatin and carboplatin are in widespread clinical use but associated with many side effects. Improving the delivery of cytotoxic platinum compounds may lead to reduced side effects and achieve greater efficacy at lower doses. Polymer-based therapeutics have been investigated...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Haxton KJ,Burt HM

    更新日期:2009-07-01 00:00:00

  • Polynitro aromatic compounds in analytical chemistry I: reaction with ouabain and digitoxin.

    abstract::By the use of NMR spectroscopy, the highly colored reaction products formed by ouabain or digitoxin in with 1,3,5-trinitrobenzene or 2,4,6-trinitroanisole in the presence of alkali (as used for the determination of these glycosides) are shown to be Meisenheimer complexes. The complexes are produced by attachment of a ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Burns LB,Stedman RJ,Tuckerman MM

    更新日期:1977-05-01 00:00:00

  • Sucrose esters increase drug penetration, but do not inhibit p-glycoprotein in caco-2 intestinal epithelial cells.

    abstract::Sucrose fatty acid esters are increasingly used as excipients in pharmaceutical products, but few data are available on their toxicity profile, mode of action, and efficacy on intestinal epithelial models. Three water-soluble sucrose esters, palmitate (P-1695), myristate (M-1695), laurate (D-1216), and two reference a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kiss L,Hellinger É,Pilbat AM,Kittel Á,Török Z,Füredi A,Szakács G,Veszelka S,Sipos P,Ózsvári B,Puskás LG,Vastag M,Szabó-Révész P,Deli MA

    更新日期:2014-10-01 00:00:00

  • Factors Influencing the Retention of Organic Solvents in Products Freeze-Dried From Co-Solvent Systems.

    abstract::Controlling residual solvent levels is a major concern in pharmaceutical freeze-drying from co-solvent systems. This review provides an overview of the factors influencing this process and estimates their potential to reduce residual solvents in freeze-dried products. Decreased solvent contents are potentially correla...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Kunz C,Gieseler H

    更新日期:2018-08-01 00:00:00

  • Flow Microscopy Imaging Is Sensitive to Characteristics of Subvisible Particles in Peginesatide Formulations Associated With Severe Adverse Reactions.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Daniels AL,Randolph TW

    更新日期:2018-05-01 00:00:00

  • Hypolipidemic activity of 6-amino-2-mercapto-5-methyl-pyrimidine-4-carboxylic acid and related derivatives in rodents.

    abstract::6-Amino-2-mercapto-5-methylpyrimidine-4-carboxylic acid proved to be a potent hypolipidemic agent in rodents at the low dose of 20 mg/kg/d. The agent effectively reduced the liver enzyme activities required for the synthesis of triglycerides and cholesterol. Lower lipid levels in tissue were observed in mice but not i...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hall IH,Cocolas GH,Murthy AR,Rhyne KA,Knowles M

    更新日期:1985-07-01 00:00:00

  • Limits on optimizing ocular drug delivery.

    abstract::The problem of optimizing ocular bioavailability of topically applied ophthalmic drugs is discussed. A formula for drug concentration in the tear film is derived using well-known pharmacokinetic relationships and a first-order drug decay model for the tear film. The time integral of the tear film concentration is then...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Keister JC,Cooper ER,Missel PJ,Lang JC,Hager DF

    更新日期:1991-01-01 00:00:00

  • Inclusion of acitretin into cyclodextrins: phase solubility, photostability, and physicochemical characterization.

    abstract::Acitretin, a retinoid for the treatment of severe psoriasis, exhibits extremely low aqueous solubility and high photosensitivity. This study investigated the effects of the complexation of acitretin with the respective hydroxypropyl-beta-cyclodextrin (HPBCD) and randomly substituted methyl-beta-cyclodextrin (RMBCD) on...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Liu X,Lin HS,Thenmozhiyal JC,Chan SY,Ho PC

    更新日期:2003-12-01 00:00:00

  • Rapid and simple GLC determination of valproic acid and ethosuximide in plasma of epileptic patients.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Riva R,Albani F,Baruzzi A

    更新日期:1982-01-01 00:00:00

  • Potentiation of the antitumor effect of 5-fluoro-2'-deoxyuridine esters in combination with acyclothymidine esters on L1210 in mice via oral administration.

    abstract::Fifteen pyrimidine-related compounds were evaluated for their ability to inhibit enzymatic degradation of 5-fluoro-2'-deoxyuridine (FUdR). Acyclothymidine [5-methyl-1-(2'-hydroxyethoxymethyl)uracil] showed the highest inhibitory effect on the phosphorolytic degradation of FUdR in various tissue homogenates derived fro...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kawaguchi T,Saito M,Saneyoshi M

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  • Mass spectrometry of chlorambucil, its degradation products, and its metabolite in biological samples.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chang SY,Larcom BJ,Alberts DS,Larsen B,Walson PD,Sipes IG

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  • Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing.

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    journal_title:Journal of pharmaceutical sciences

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    authors: Jermain B,Hanafin PO,Cao Y,Lifschitz A,Lanusse C,Rao GG

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bis RL,Singh SM,Cabello-Villegas J,Mallela KM

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kim D,Hong S,Jung S,Jung Y,Kim YM

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  • Disposition of 8-methyl-8-azabicyclo[3,2,1]octan-3-yl 3,5-dichlorobenzoate, a potent 5-hydroxytryptamine antagonist, and two metabolites in dogs and monkeys.

    abstract::The disposition of 8-methyl-8-azabicyclo[3,2,1]octan-3-yl 3,5-dichlorobenzoate (MDL 72,222; 1), a potent 5-hydroxytryptamine antagonist, and its N-demethylated and N-oxide metabolites was studied in dogs and monkeys. After single, intravenous doses of 1 at 5 mg/kg, the mean terminal half-lives of 1 in plasma were 2.6 ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cheng H,Larsen DL,Ragner JA,Sproles GD,Gordon WP

    更新日期:1992-04-01 00:00:00

  • Scavenger effect of vitamin E and derivatives on free radicals generated by photoirradiated pheomelanin.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Duval C,Poelman MC

    更新日期:1995-01-01 00:00:00

  • Disposition kinetics of nicotine and cotinine enantiomers in rabbits and beagle dogs.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Jacob P 3rd,Benowitz NL,Copeland JR,Risner ME,Cone EJ

    更新日期:1988-05-01 00:00:00

  • Investigation of Dose-Dependent Factors Limiting Oral Bioavailability: Case Study With the PI3K-δ Inhibitor.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chiang PC,Sutherlin D,Pang J,Salphati L

    更新日期:2016-06-01 00:00:00

  • Dissolution of theophylline monohydrate and anhydrous theophylline in buffer solutions.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: de Smidt JH,Fokkens JG,Grijseels H,Crommelin DJ

    更新日期:1986-05-01 00:00:00