Noninvasive identification of materials inside USP vials with Raman spectroscopy and a Raman spectral library.

Abstract:

:A commercial dispersive Raman spectrometer operating at 785 nm with a CCD detector was used to acquire spectra of USP reference materials inside amber USP vials. The laser and collection beams were directed through the bottom of the vials, resulting in a 60% loss of signal. The Raman shift was calibrated with a 4-acetamidophenol standard, and spectral response was corrected with a luminescent standard. After these corrections, the Raman spectra obtained inside the USP vial and on open powders differed by less than 5%. A spectral library of 309 reference materials was constructed, with spectral acquisition times ranging from 1 to 60 s. Of these, 8% had significant fluorescent background but observable Raman features, while 3% showed only fluorescence. A blind test of 26 unknowns revealed the accuracy of the library search to be 88-96%, depending on search algorithm, and 100% if operator discretion was permitted. The tolerance of the library search to degraded signal-to-noise ratio, resolution, and Raman shift accuracy were tested, and the search was very robust. The results demonstrate that Raman spectroscopy provides a rapid, noninvasive technique for compound identification.

journal_name

J Pharm Sci

authors

McCreery RL,Horn AJ,Spencer J,Jefferson E

doi

10.1021/js970330q

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

1-8

issue

1

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)50476-0

journal_volume

87

pub_type

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