Abstract：
:Carbamazepine is the first-line anti-epileptic drug for focal seizures and generalized tonic-clonic seizures. Although sustained-release formulations exist, an initial burst of drug release is still present and this results in side effects. Zero-order release formulations reduce fluctuations in serum drug concentrations, thereby reducing side effects. Three-dimensional printing can potentially fabricate zero-order release formulations with complex geometries. 3D printed scaffolds with varying hole positions (side and top/bottom), number of holes (4, 8, and 12), and hole diameters (1, 1.5, and 2 mm) were designed. Dissolution tests and high performance liquid chromatography analysis were conducted. Good correlations in the linear release profiles of all carbamazepine-containing scaffolds with side holes (R(2) of at least 0.91) were observed. Increasing the hole diameters (1, 1.5, and 2 mm) resulted in increased rate of drug release in the scaffolds with 4 holes (0.0048, 0.0065, and 0.0074 mg/min) and 12 holes (0.0021, 0.0050, and 0.0092 mg/min), and the initial amount of carbamazepine released in the scaffolds with 8 holes (0.4348, 0.7246, and 1.0246 mg) and 12 holes (0.1995, 0.8598, and 1.4366 mg). The ultimate goal of this research is to improve the compliance of patients through a dosage form that provides a zero-order drug release profile for anti-epileptic drugs, so as to achieve therapeutic doses and minimize side effects.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Lim SH,Chia SM,Kang L,Yap KYdoi
10.1016/j.xphs.2016.04.031subject
Has Abstractpub_date
2016-07-01 00:00:00pages
2155-63issue
7eissn
0022-3549issn
1520-6017pii
S0022-3549(16)41405-Xjournal_volume
105pub_type
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doi：10.1002/jps.2600690217
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doi：10.1002/jps.2600640613
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doi：10.1002/jps.2600720904
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journal_title：Journal of pharmaceutical sciences
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abstract：:A few 1,2-bis(N-alkylaminomethyl)indolizines, simple indolizinecarboxylic acids, and several 6-alkoxyindolizine-2-carboxylic acids were synthesized and screened as possible oral hypoglycemic agents. The absence of any significant hypoglycemic activity excludes these compounds from the predicted structural lead provide...
journal_title：Journal of pharmaceutical sciences
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更新日期：1975-02-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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