Application of the ammonia gas-sensing electrode: determination of drugs having a carbothionamido group by decomposition with acid.

Abstract:

:A method to determine drugs having a carbothionamido group using an ammonia gas-sensing electrode is described. To obtain analytical accuracy, the effect of factors that influence the potential is also discussed. Ethionamide or prothionamide was refluxed with 20% HCl to give ammonium chloride, hydrogen sulfide, and a carboxylic acid. The ammonia, which evolved at pH greater than 11, was determined. A linear calibration plot was obtained within the drug concentration range of 2 X 10(-5)--1 X 10(-2) M.

journal_name

J Pharm Sci

authors

Tagami S,Maeda H

doi

10.1002/jps.2600720904

subject

Has Abstract

pub_date

1983-09-01 00:00:00

pages

988-91

issue

9

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)44772-0

journal_volume

72

pub_type

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