Abstract:
:A method to determine drugs having a carbothionamido group using an ammonia gas-sensing electrode is described. To obtain analytical accuracy, the effect of factors that influence the potential is also discussed. Ethionamide or prothionamide was refluxed with 20% HCl to give ammonium chloride, hydrogen sulfide, and a carboxylic acid. The ammonia, which evolved at pH greater than 11, was determined. A linear calibration plot was obtained within the drug concentration range of 2 X 10(-5)--1 X 10(-2) M.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Tagami S,Maeda Hdoi
10.1002/jps.2600720904subject
Has Abstractpub_date
1983-09-01 00:00:00pages
988-91issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(15)44772-0journal_volume
72pub_type
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