Abstract:
:Detection and quantification of the amorphous phase of etoricoxib bulk drug substances, a selective cycloogenase-2 inhibitor used for the treatment of osteoarthritis, rheumatoid arthritis, and dental pain, was carried out using modulated differential scanning calorimetry (MDSC), dynamic mechanical analysis (DMA), and Raman spectroscopy. Detection of amorphous content in pharmaceutical powders by DMA is a special application of dynamic mechanical spectroscopy. DMA was found to be a sensitive technique, able to detect the presence of an amorphous phase in a crystalline phase at concentrations as low as 0.5%. The limit of detection (LOD) determined for DMA was 2.5%. In comparison, Raman spectroscopy and MDSC had LOD values of 2% and 5% amorphous, respectively.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Clas SD,Lalonde K,Khougaz K,Dalton CR,Bilbeisi Rdoi
10.1002/jps.22774subject
Has Abstractpub_date
2012-02-01 00:00:00pages
558-65issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(15)31703-2journal_volume
101pub_type
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