Life-threatening false alarm rejection in ICU: using the rule-based and multi-channel information fusion method.


:False alarm (FA) rates as high as 86% have been reported in intensive care unit monitors. High FA rates decrease quality of care by slowing staff response times while increasing patient burdens and stresses. In this study, we proposed a rule-based and multi-channel information fusion method for accurately classifying the true or false alarms for five life-threatening arrhythmias: asystole (ASY), extreme bradycardia (EBR), extreme tachycardia (ETC), ventricular tachycardia (VTA) and ventricular flutter/fibrillation (VFB). The proposed method consisted of five steps: (1) signal pre-processing, (2) feature detection and validation, (3) true/false alarm determination for each channel, (4) 'real-time' true/false alarm determination and (5) 'retrospective' true/false alarm determination (if needed). Up to four signal channels, that is, two electrocardiogram signals, one arterial blood pressure and/or one photoplethysmogram signal were included in the analysis. Two events were set for the method validation: event 1 for 'real-time' and event 2 for 'retrospective' alarm classification. The results showed that 100% true positive ratio (i.e. sensitivity) on the training set were obtained for ASY, EBR, ETC and VFB types, and 94% for VTA type, accompanied by the corresponding true negative ratio (i.e. specificity) results of 93%, 81%, 78%, 85% and 50% respectively, resulting in the score values of 96.50, 90.70, 88.89, 92.31 and 64.90, as well as with a final score of 80.57 for event 1 and 79.12 for event 2. For the test set, the proposed method obtained the score of 88.73 for ASY, 77.78 for EBR, 89.92 for ETC, 67.74 for VFB and 61.04 for VTA types, with the final score of 71.68 for event 1 and 75.91 for event 2.


Physiol Meas


Liu C,Zhao L,Tang H,Li Q,Wei S,Li J




Has Abstract


2016-08-01 00:00:00












  • Measuring gait with an accelerometer-based wearable: influence of device location, testing protocol and age.

    abstract::Wearables such as accelerometers are emerging as powerful tools for quantifying gait in various environments. Flexibility in wearable location may improve ease of use and data acquisition during instrumented testing. However, change of location may impact algorithm functionality when evaluating associated gait charact...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Del Din S,Hickey A,Hurwitz N,Mathers JC,Rochester L,Godfrey A

    更新日期:2016-10-01 00:00:00

  • Classification of cognitive reserve in healthy older adults based on brain activity using support vector machine.

    abstract:OBJECTIVE:Cognitive reserve (CR) refers to the capacity of the brain to actively cope with damage via the implementation of remedial cognitive processes. Traditional CR measurements focus on static proxies, which may not be able to appropriately estimate dynamic changes in CR. This study therefore investigated the cogn...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Yang CY,Lin CP

    更新日期:2020-07-07 00:00:00

  • Repeatability of body sway measurements; day-to-day variation measured by sway magnetometry.

    abstract::The postural stability of 30 normal subjects in the age range 15 to 64 years was measured on five separate occasions, using the sway magnetometry technique, to determine the day-to-day repeatability of this measurement technique. On each occasion the pathlength and area enclosed by movement of the hips in a horizontal...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Elliott C,Murray A

    更新日期:1998-05-01 00:00:00

  • A comparison of technologies used for estimation of body temperature.

    abstract::Body temperature measurement is an important clinical parameter. The performance of a number of non-invasive thermometers was measured by comparing intra- and inter-operator variability (n = 100) and clinical accuracy (n = 61). Variability was elevated in febrile compared to normothermic subjects for axillary and oral...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Mangat J,Standley T,Prevost A,Vasconcelos J,White P

    更新日期:2010-09-01 00:00:00

  • Effects of CO2 on dynamic cerebral autoregulation measurement.

    abstract::Arterial pCO2 is known to influence cerebral autoregulation but its effect on the dynamic relationship between mean arterial blood pressure (ABP) and mean cerebral blood flow velocity (CBFV), obtained from spontaneous fluctuations in ABP, has not been established. In 16 normal subjects, ABP was measured non-invasively...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Panerai RB,Deverson ST,Mahony P,Hayes P,Evans DH

    更新日期:1999-08-01 00:00:00

  • A CT perfusion based model predicts outcome in wake-up stroke patients treated with recombinant tissue plasminogen activator.

    abstract:OBJECTIVE:Advanced neuroimaging has proved to be pivotal in the management of acute ischemic stroke. The use of CT perfusion (CTP) core and penumbra parameters to predict the outcome in wake-up stroke (WUS) patients in everyday clinical scenarios has not yet been investigated. The aim of our study was to investigate th...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Ajčević M,Furlanis G,Stella AB,Cillotto T,Caruso P,Ridolfi M,Lugnan C,Miladinović A,Ukmar M,Cova MA,Accardo A,Manganotti P,Naccarato M

    更新日期:2020-08-11 00:00:00

  • Use of the discriminant Fourier-derived cepstrum with feature-level post-processing for surface electromyographic signal classification.

    abstract::Myoelectrical pattern classification is a crucial part in multi-functional prosthesis control. This paper investigates a discriminant Fourier-derived cepstrum (DFC) and feature-level post-processing (FLPP) to discriminate hand and wrist motions using the surface electromyographic signal. The Fourier-derived cepstrum t...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Chen X,Zhu X,Zhang D

    更新日期:2009-12-01 00:00:00

  • Multiple breath washout analysis in infants: quality assessment and recommendations for improvement.

    abstract::Infant multiple breath washout (MBW) testing serves as a primary outcome in clinical studies. However, it is still unknown whether current software algorithms allow between-centre comparisons. In this study of healthy infants, we quantified MBW measurement errors and tried to improve data quality by simply changing so...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Anagnostopoulou P,Egger B,Lurà M,Usemann J,Schmidt A,Gorlanova O,Korten I,Roos M,Frey U,Latzin P

    更新日期:2016-03-01 00:00:00

  • Eye-tracker algorithms to detect saccades during static and dynamic tasks: a structured review.

    abstract:OBJECTIVE:Eye-tracking devices have become widely used as clinical assessment tools in a variety of applied-scientific fields to measure saccadic eye movements. With the emergence of multiple static and dynamic devices, the concurrent need for algorithm development and validation is paramount. APPROACH:This review ass...

    journal_title:Physiological measurement

    pub_type: 杂志文章,评审


    authors: Stuart S,Hickey A,Vitorio R,Welman K,Foo S,Keen D,Godfrey A

    更新日期:2019-02-26 00:00:00

  • Modelling the electrical properties of bladder tissue--quantifying impedance changes due to inflammation and oedema.

    abstract::Electrical impedance spectroscopy has been developed as a potential method for the diagnosis of carcinoma in epithelial tissues. An understanding of the influence of structural changes in the tissue on the properties measured using this technique is essential for interpreting measured data and optimization of probe de...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Walker DC,Smallwood RH,Keshtar A,Wilkinson BA,Hamdy FC,Lee JA

    更新日期:2005-06-01 00:00:00

  • Determination of Cole parameters in multiple frequency bioelectrical impedance analysis using only the measurement of impedances.

    abstract::Conventional bioimpedance spectrometers measure resistance and reactance over a range of frequencies and, by application of a mathematical model for an equivalent circuit (the Cole model), estimate resistance at zero and infinite frequencies. Fitting of the experimental data to the model is accomplished by iterative, ...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Ward LC,Essex T,Cornish BH

    更新日期:2006-09-01 00:00:00

  • Empirical estimators of gamma fits to tracer-dilution curves and their technical basis and practical scope.

    abstract::A gamma fit facilitates smoothing and extrapolation of distorted tracer-dilution curves in blood flow studies. Theoretically based empirical estimators were developed as simple alternatives to direct regression approaches from simulated gamma distributions with a wide range of shape asymmetry. Key curve features of pe...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Lopatatzidis A,Millard RK

    更新日期:2001-11-01 00:00:00

  • Assessing the validity and reliability and determining cut-points of the Actiwatch 2 in measuring physical activity.

    abstract:OBJECTIVE:The Actiwatch 2 (AW2) is a wrist-worn accelerometer typically used to measure sleep. Although it can measure physical activity, there is limited evidence supporting its validity. We assessed the validity and reliability of the AW2 to measure sedentary behavior and physical activity (light, moderate, vigorous ...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Kemp C,Pienaar PR,Henst RHP,Roden LC,Kolbe-Alexander TL,Rae DE

    更新日期:2020-09-04 00:00:00

  • Neuromagnetic field strength outside the human head due to impedance changes from neuronal depolarization.

    abstract::The holy grail of neuroimaging would be to have an imaging system, which could image neuronal electrical activity over milliseconds. One way to do this would be by imaging the impedance changes associated with ion channels opening in neuronal membranes in the brain during activity. In principle, we could measure this ...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Ahadzi GM,Liston AD,Bayford RH,Holder DS

    更新日期:2004-02-01 00:00:00

  • Machine learning for nocturnal mass diagnosis of atrial fibrillation in a population at risk of sleep-disordered breathing.

    abstract:OBJECTIVE:In this research, we introduce a new methodology for atrial fibrillation (AF) diagnosis during sleep in a large population sample at risk of sleep-disordered breathing. APPROACH:The approach leverages digital biomarkers and recent advances in machine learning (ML) for mass AF diagnosis from overnight-hours o...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Chocron A,Efraim R,Mandel F,Rueschman M,Palmius N,Penzel T,Elbaz M,Behar JA

    更新日期:2020-11-06 00:00:00

  • A novel curve fitting method for AV optimisation of biventricular pacemakers.

    abstract::In this study, we designed and tested a new algorithm, which we call the 'restricted parabola', to identify the optimum atrioventricular (AV) delay in patients with biventricular pacemakers. This algorithm automatically restricts the hemodynamic data used for curve fitting to the parabolic zone in order to avoid inadv...

    journal_title:Physiological measurement

    pub_type: 杂志文章,随机对照试验


    authors: Dehbi HM,Jones S,Sohaib SM,Finegold JA,Siggers JH,Stegemann B,Whinnett ZI,Francis DP

    更新日期:2015-09-01 00:00:00

  • The physiological impact of the nonlinearity of arterial elasticity in the ambulatory arterial stiffness index.

    abstract::The ambulatory arterial stiffness index (AASI) is claimed to be a new estimator for arterial rigidity. It was recently defined as one minus the slope of the linear regression of systolic to diastolic ambulatory pressure during 24 h. Although several reports testify its clinical relevance, the explanation of how this n...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Craiem D,Graf S,Salvucci F,Chironi G,Megnien JL,Simon A,Armentano RL

    更新日期:2010-07-01 00:00:00

  • Real-time chest-wall-motion tracking by a single optical fibre grating: a prospective method for ventilator triggering.

    abstract:OBJECTIVE:The ventilators involved in non-invasive mechanical ventilation commonly provide ventilator support via a facemask. The interface of the mask with a patient promotes air leaks that cause errors in the feedback information provided by a pneumatic sensor and hence patient-ventilator asynchrony with multiple neg...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Ivanović MD,Petrovic J,Savić A,Gligorić G,Miletić M,Vukčević M,Bojović B,Hadžievski L,Allsop T,Webb DJ

    更新日期:2018-04-26 00:00:00

  • Assessment of cerebrospinal fluid outflow conductance using constant-pressure infusion--a method with real time estimation of reliability.

    abstract::The outflow conductance (C(out)) of the cerebrospinal fluid (CSF) system is a parameter considered to be predictive in selection for hydrocephalus surgery. C(out) can be determined through an infusion test. A new apparatus for performing infusion tests in a standardized and automated way was developed. The objective w...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Andersson N,Malm J,Bäcklund T,Eklund A

    更新日期:2005-12-01 00:00:00

  • Restoration of the electrocardiogram during mechanical cardiopulmonary resuscitation.

    abstract:OBJECTIVE:An artefact-free electrocardiogram (ECG) is essential during cardiac arrest to decide therapy such as defibrillation. Mechanical cardiopulmonary resuscitation (CPR) devices cause movement artefacts that alter the ECG. This study analyzes the effectiveness of mechanical CPR artefact suppression filters to rest...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Isasi I,Irusta U,Aramendi E,Idris AH,Sörnmo L

    更新日期:2020-11-06 00:00:00

  • Within-breath measurement of respiratory impedance.

    abstract::The measurement of the complex respiratory impedance at a high temporal resolution is described. The measurement of impedance is correlated with the breathing cycle using electrical transthoracic impedance. This allows the determination of the complex impedance at any fixed point in the respiratory cycle, which result...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: van der Putten WJ,MacLeod D,Prichard JS

    更新日期:1993-08-01 00:00:00

  • The contribution of vascular smooth muscle, elastin and collagen on the passive mechanics of porcine carotid arteries.

    abstract::The main components responsible for the mechanical behavior of the arterial wall are collagen, elastin, and smooth muscle cells (SMCs) in the medial layer. We determined the structural and mechanical changes in porcine carotid arteries after administration of Triton® X-100, elastase, and collagenase using the inflatio...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Kochová P,Kuncová J,Svíglerová J,Cimrman R,Miklíková M,Liška V,Tonar Z

    更新日期:2012-08-01 00:00:00

  • Specific heat capacity of freshly excised prostate specimens.

    abstract::The specific heat capacity of tissue is a critical parameter for thermal therapies that act over a long period of time. It is also critical for thermoacoustic signal generation. We present ex vivo measurements of specific heat capacity performed by a dual-pin probe with tight temperature control of the specimen. One 3...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Patch SK,Rao N,Kelly H,Jacobsohn K,See WA

    更新日期:2011-11-01 00:00:00

  • Regional changes in cerebral blood flow oxygenation can indicate global changes in cerebral blood flow during coronary artery occlusion in juvenile pigs.

    abstract::Near infrared spectroscopy (NIRS) is a widely employed method for assessment of regional cerebral oxygenation (RcStO2). RcStO2 values are expected to vary with changes in the relative amount of oxyhaemoglobin. The present experimental study aimed to assess the response of RcStO2 to controlled alterations of carotid bl...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Svenmarker S,Häggmark S,Johansson G,Axelsson B,Wiklund U,Haney M

    更新日期:2014-07-01 00:00:00

  • Design considerations and performance of a prototype system for imaging neuronal depolarization in the brain using 'direct current' electrical resistance tomography.

    abstract::The ability to image the impedance changes that accompany neuronal depolarization in the brain would constitute a major advance in neuroscience technology. Unfortunately, these changes are likely to be small and rapid and so difficult to measure. The impedance change at frequencies above 10 kHz, as used by conventiona...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Boone KG,Holder DS

    更新日期:1995-08-01 00:00:00

  • EITS changes following oleic acid induced lung water.

    abstract::We present the results of using electrical impedance tomographic spectroscopy (EITS) to follow the changes in lung water induced by oleic acid. Measurements were made on three goats before and after the injection of oleic acid. In addition to the EITs measurements, lung water was also measured using a double-indicator...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Brown BH,Flewelling R,Griffiths H,Harris ND,Leathard AD,Lu L,Morice AH,Neufeld GR,Nopp P,Wang W

    更新日期:1996-11-01 00:00:00

  • Modelling the cerebral haemodynamic response in the physiological range of PaCO2.

    abstract:OBJECTIVE:Arterial CO2 (PaCO2) has a strong effect on cerebral blood flow (CBF), but its influence on CBF regulatory mechanisms and circulatory systemic variables has not been fully described over the entire physiological range of PaCO2. APPROACH:CBF velocity (CBFV, transcranial Doppler), blood pressure (BP, Finometer...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Minhas JS,Panerai RB,Robinson TG

    更新日期:2018-06-19 00:00:00

  • Compressive sensing in electrical impedance tomography for breathing monitoring.

    abstract:OBJECTIVE:Electrical impedance tomography (EIT) is a functional imaging technique in which cross-sectional images of structures are reconstructed based on boundary trans-impedance measurements. Continuous functional thorax monitoring using EIT has been extensively researched. Increasing the number of electrodes, number...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Shiraz A,Khodadad D,Nordebo S,Yerworth R,Frerichs I,van Kaam A,Kallio M,Papadouri T,Bayford R,Demosthenous A

    更新日期:2019-04-03 00:00:00

  • Causality in physiological signals.

    abstract::Health is one of the most important non-material assets and thus also has an enormous influence on material values, since treating and preventing diseases is expensive. The number one cause of death worldwide today originates in cardiovascular diseases. For these reasons the aim of understanding the functions and the ...

    journal_title:Physiological measurement

    pub_type: 杂志文章,评审


    authors: Müller A,Kraemer JF,Penzel T,Bonnemeier H,Kurths J,Wessel N

    更新日期:2016-05-01 00:00:00

  • In vivo measurement of human skin absorption of topically applied substances by a photoacoustic technique.

    abstract::A photoacoustic technique is used for studying topically applied substance absorption in human skin. The proposed method utilizes a double-chamber PA cell. The absorption determination was obtained through the measurement of the thermal effusivity of the binary system substance-skin. The theoretical model assumes that...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Gutiérrez-Juárez G,Vargas-Luna M,Córdova T,Varela JB,Bernal-Alvarado JJ,Sosa M

    更新日期:2002-08-01 00:00:00