Home monitoring of within-breath respiratory mechanics by a simple and automatic forced oscillation technique device.


:Spirometry is the gold standard to determine the presence of airflow obstruction, but it requires volitional participation and needs qualified supervision. The forced oscillation technique (FOT) measures respiratory input impedance (Zrs) during spontaneous breathing and it could be useful for unsupervised monitoring of airway obstruction. We developed a FOT device for home monitoring of Zrs which transmits the data through the Internet. Its accuracy, stability and reliability were evaluated in a pilot study measuring the Zrs in the unsupervised self-measurements of five healthy subjects. Finally, to explore the applicability of the concept, 36 consecutive daily home measurements were recorded from one healthy subject and one chronic obstructive pulmonary disease (COPD) patient. The accuracy of the device fulfilled FOT guidelines, and the reliability test showed a mean discrepancy of resistance of 0.10 +/- 0.01 cmH(2)O s L(-1). The data from the healthy subjects demonstrated high repeatability in assessing Zrs. The measurements on the healthy subjects and the patient with COPD suggest the feasibility of unsupervised FOT measurements. The healthy subjects showed minimal daily variations in Zrs, whereas the patient with COPD had large differences in mean values and important fluctuations over day-to-day measurements. The results of the pilot study demonstrate that unsupervised home monitoring of Zrs using the FOT yields accurate and reproducible data. It could provide new insights into the dynamics of airway obstruction and improve the understanding and management of obstructive diseases.


Physiol Meas


Dellacà RL,Gobbi A,Pastena M,Pedotti A,Celli B




Has Abstract


2010-04-01 00:00:00














  • Esophageal temperature monitoring during radiofrequency catheter ablation: experimental study based on an agar phantom model.

    abstract::Although previous studies have established the feasibility of monitoring esophageal temperature during radiofrequency cardiac ablation using an esophageal temperature probe (ETP), some questions remain regarding its efficacy. The aims of this study were to study the effect of the location of the ETP on the temperature...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Rodríguez I,Lequerica JL,Berjano EJ,Herrero M,Hornero F

    更新日期:2007-05-01 00:00:00

  • A phantom for evaluating bone mineral density of the hand by dual-energy x-ray absorptiometry.

    abstract::Dual-energy x-ray absorptiometry (DXA) is a precise, widely used method for measuring bone mineral density (BMD), usually of the lumbar spine and femoral neck. Recent developments, such as a lower x-ray tube current and pixel by pixel analysis, enable smaller bones and thinner tissues volumes, as in the hand, to be me...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Steel SA,Swann P,Langley G,Langton CM

    更新日期:1997-08-01 00:00:00

  • Localization of sources of brain alpha/theta/delta activity and the influence of the mode of spontaneous mentation.

    abstract::A method is described that accounts for multichannel brain field data (EEG) epochs, after transformation into the frequency domain, by a single oscillating dipole source in terms of phase angles. The method produces a potential distribution for each frequency point ('FFT dipole approximation'). These maps can be subje...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Michel CM,Henggeler B,Brandeis D,Lehmann D

    更新日期:1993-11-01 00:00:00

  • A bio-telemetric device for measurement of left ventricular pressure-volume loops using the admittance technique in conscious, ambulatory rats.

    abstract::This paper presents the design, construction and testing of a device to measure pressure-volume loops in the left ventricle of conscious, ambulatory rats. Pressure is measured with a standard sensor, but volume is derived from data collected from a tetrapolar electrode catheter using a novel admittance technique. Ther...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Raghavan K,Feldman MD,Porterfield JE,Larson ER,Jenkins JT,Escobedo D,Pearce JA,Valvano JW

    更新日期:2011-06-01 00:00:00

  • A novel method for continuous blood pressure estimation based on a single-channel photoplethysmogram signal.

    abstract:OBJECTIVE:Currently, continuous blood pressure (BP) measurements are mostly based on multi-sensor combinations and datasets with limited BP ranges. Besides, most BP-related features derive from the photoplethysmogram (PPG) signal. The mechanism of PPG signal formation is not considered. We aimed to design a noninvasive...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Hu Q,Deng X,Wang A,Yang C

    更新日期:2021-01-01 00:00:00

  • Cardiac-related changes in lung resistivity as a function of frequency and location obtained from EITS images.

    abstract::ECG-gated electrical impedance tomographic spectroscopy (EITS) measurements of the lungs were taken on seven normal subjects in the frequency range 9.6 kHz to 614.4 kHz. The results show that in late systole the resistivity p' relative to the R-wave (i.e. p' = 1 at the R-wave) decreases consistently within the lung. I...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Nopp P,Zhao TX,Brown BH,Wang W

    更新日期:1996-11-01 00:00:00

  • A measurement of pulmonary blood volume increase during systole in humans.

    abstract::Pulmonary blood volume increase during systole was measured in patients by analysing chest images obtained during ECG gated radionuclide angiography examination. The difference in the total radiation counts between systole and diastole in regions of interest, which included the lungs and the left ventricle, was measur...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章


    authors: Nitzan M,Mahler Y,Schechter D,Yaffe S,Bocher M,Chisin R

    更新日期:1994-11-01 00:00:00

  • Physiological motion monitoring: a wearable device and adaptative algorithm for sit-to-stand timing detection.

    abstract::A simple wearable device for sit-to-stand timing detection was designed and constructed with rate gyroscopes and accelerometers and a dedicated adaptive algorithm. The method was validated by comparison with optoelectronic equipment. Results from the comparison showed a maximal error always lower than 2.5 x 10(-2) s f...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Giansanti D,Maccioni G

    更新日期:2006-08-01 00:00:00

  • Determination of Cole parameters in multiple frequency bioelectrical impedance analysis using only the measurement of impedances.

    abstract::Conventional bioimpedance spectrometers measure resistance and reactance over a range of frequencies and, by application of a mathematical model for an equivalent circuit (the Cole model), estimate resistance at zero and infinite frequencies. Fitting of the experimental data to the model is accomplished by iterative, ...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Ward LC,Essex T,Cornish BH

    更新日期:2006-09-01 00:00:00

  • EIT data noise evaluation in the clinical environment.

    abstract::In the clinical environment the reliable interpretation of EIT images depends on the quality of the data. In the electrically noisy hospital environment the system performance needs to be assessed for each clinical investigation. From the model of noise presented, a figure of merit for comparisons of system performanc...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Meeson S,Blott BH,Killingback AL

    更新日期:1996-11-01 00:00:00

  • Transthoracic electrical impedance during external defibrillation: comparison of measured and modelled waveforms.

    abstract::The transthoracic electrical impedance is an important defibrillation parameter, affecting the defibrillating current amplitude and energy, and therefore the defibrillation efficiency. A close relationship between transthoracic impedance and defibrillation success rate was observed. Pre-shock measurements (using low a...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Al Hatib F,Trendafilova E,Daskalov I

    更新日期:2000-02-01 00:00:00

  • Storage effects on the Cole-Cole parameters of erythrocyte suspensions.

    abstract::Chemical alterations of red blood cells (RBCs) during storage eventually affect the electrical properties of blood. In this study, the physiological parameters such as extracellular (SAGM + CPD + residual plasma) Na(+), K(+), Cl(-), pH, 2,3-DPG and ATP together with the Cole-Cole parameters were measured using erythro...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Sezdi M,Bayik M,Ulgen Y

    更新日期:2006-07-01 00:00:00

  • Limited agreement between two noninvasive measurements of blood volume during fluid removal: ultrasound of inferior vena cava and finger-clip spectrophotometry of hemoglobin concentration.

    abstract:OBJECTIVE:Plots of blood volume measurements over time (profiles) may identify euvolemia during fluid removal for acute heart failure. We assessed agreement between two noninvasive measurements of blood volume profiles during mechanical fluid removal, which exemplifies the interstitial fluid shifts that occur during di...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Lucas BP,D'Addio A,Block C,Manning H,Remillard B,Leiter JC

    更新日期:2019-07-01 00:00:00

  • Phase shift between respiratory oscillations in cerebral blood flow velocity and arterial blood pressure.

    abstract::We aim to investigate whether phase shift between respiratory oscillations in cerebral blood flow velocity (CBFV) and arterial blood pressure (ABP) is associated with changes in cerebral autoregulation (CA) or reflects the mechano-elastic properties of the cerebrovascular bed. The relationships between respiratory pha...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Uryga A,Placek MM,Wachel P,Szczepański T,Czosnyka M,Kasprowicz M

    更新日期:2017-02-01 00:00:00

  • Transthoracic impedance study with large self-adhesive electrodes in two conventional positions for defibrillation.

    abstract::External defibrillation requires the application of high voltage electrical impulses via large external electrodes, placed on selected locations on the thorax surface. The position of the electrodes is one of the major determinants of the transthoracic impedance (TTI) which influences the intracardiac current flow dur...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Krasteva V,Matveev M,Mudrov N,Prokopova R

    更新日期:2006-10-01 00:00:00

  • Recording of ENGs from the nerves innervating the pancreas of a dog during the intravenous glucose tolerance test.

    abstract::Electroneurograms (ENGs) from the vagus nerve (VN), the splanchnic nerve (SN) and the pancreatic nerve (PN) innervating the pancreas of a dog, were recorded with chronically implanted 33-electrode spiral cuffs (cuff) before and after the pancreas were stimulated with intravenously (i.v.) administered glucose. In the c...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Rozman J,Zorko B,Bunc M,Mikac U,Tegou E

    更新日期:2002-11-01 00:00:00

  • A novel curve fitting method for AV optimisation of biventricular pacemakers.

    abstract::In this study, we designed and tested a new algorithm, which we call the 'restricted parabola', to identify the optimum atrioventricular (AV) delay in patients with biventricular pacemakers. This algorithm automatically restricts the hemodynamic data used for curve fitting to the parabolic zone in order to avoid inadv...

    journal_title:Physiological measurement

    pub_type: 杂志文章,随机对照试验


    authors: Dehbi HM,Jones S,Sohaib SM,Finegold JA,Siggers JH,Stegemann B,Whinnett ZI,Francis DP

    更新日期:2015-09-01 00:00:00

  • Short-term studies of heart rate variability: comparison of two methods for recording.

    abstract::Heart rate variability (HRV) is often analysed using short-term studies. Our objective was to compare two of them in a group of diabetic patients (reduced HRV) and in a control group. From the same 10 min surface electrocardiogram (ECG) two recordings were obtained. In one of them the whole signal was acquired through...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章


    authors: Migliaro ER,Canetti R,Contreras P,Hakas M,Eirea G,Machado A

    更新日期:2004-12-01 00:00:00

  • Measurement of pupil reactivity using fast pupillometry.

    abstract::Analysis of human eye pupil reactivity is a very valuable diagnostic method used mainly for evaluation of the condition of the autonomic nervous system and the visual system. The paper presents an experimental pupillometer built in the Institute of Physics of the Wroclaw University of Technology. The apparatus makes i...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Hachol A,Szczepanowska-Nowak W,Kasprzak H,Zawojska I,Dudzinski A,Kinasz R,Wygledowska-Promienska D

    更新日期:2007-01-01 00:00:00

  • Restoration of the electrocardiogram during mechanical cardiopulmonary resuscitation.

    abstract:OBJECTIVE:An artefact-free electrocardiogram (ECG) is essential during cardiac arrest to decide therapy such as defibrillation. Mechanical cardiopulmonary resuscitation (CPR) devices cause movement artefacts that alter the ECG. This study analyzes the effectiveness of mechanical CPR artefact suppression filters to rest...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Isasi I,Irusta U,Aramendi E,Idris AH,Sörnmo L

    更新日期:2020-11-06 00:00:00

  • Age-related changes in pulse risetime measured by multi-site photoplethysmography.

    abstract:OBJECTIVE:It is accepted that changes in the peripheral pulse waveform characteristics occur with ageing. Pulse risetime is one important feature which has clinical value. However, it is unclear how it varies across the full age spectrum from child to senior and for different peripheral measurement sites. The objective...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Allen J,O'Sullivan J,Stansby G,Murray A

    更新日期:2020-08-11 00:00:00

  • Assessment of hepatic fatty infiltration using dual-energy computed tomography: a phantom study.

    abstract::The purpose of this study was to examine the performance of dual-energy computed tomography (DECT) for the quantification of liver fat content (LFC). We prepared two phantoms: homogenized mixtures of porcine liver and fat and homogeneous mixtures of liver- and fat-equivalent solutions. Tubes containing mixtures with k...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Li JH,Tsai CY,Huang HM

    更新日期:2014-04-01 00:00:00

  • Multi-frequency parameter mapping of electrical impedance scanning using two kinds of circuit model.

    abstract::Electrical impedance scanning (EIS) is a kind of potential bio-impedance measurement technology, especially aiding the diagnosis of breast cancer in women. By changing the frequency of the driving signal in turn while keeping the other conditions stable, multi-frequency measurement results on the object can be obtaine...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Liu R,Dong X,Fu F,You F,Shi X,Ji Z,Wang K

    更新日期:2007-07-01 00:00:00

  • An electrical impedance tomography system for gynecological application GIT with a tiny electrode array.

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    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: V A C,Y V G,A V K,S A S,T S T

    更新日期:2012-05-01 00:00:00

  • Electrical impedance myography at frequencies up to 2 MHz.

    abstract::Extension of the frequency range of electrical impedance myography (EIM) to 2 MHz discloses a major rise in the reactance of muscle above 3-500 kHz, together with a slow decrease in the resistance consonant with the Kramers-Kronig relations. This 'upturn' phenomenon is found when the distant current electrode configur...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章


    authors: Shiffman CA,Kashuri H,Aaron R

    更新日期:2008-06-01 00:00:00

  • Dynamic time warping and machine learning for signal quality assessment of pulsatile signals.

    abstract::In this work, we describe a beat-by-beat method for assessing the clinical utility of pulsatile waveforms, primarily recorded from cardiovascular blood volume or pressure changes, concentrating on the photoplethysmogram (PPG). Physiological blood flow is nonstationary, with pulses changing in height, width and morphol...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Li Q,Clifford GD

    更新日期:2012-09-01 00:00:00

  • Patient-specific simulations and measurements of the magneto-hemodynamic effect in human primary vessels.

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    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Kyriakou A,Neufeld E,Szczerba D,Kainz W,Luechinger R,Kozerke S,McGregor R,Kuster N

    更新日期:2012-02-01 00:00:00

  • An abdominal wall simulator for testing suprapubic urinary catheters.

    abstract::Urinary catheters (drainage tubes) are in widespread use. The most common type of long-term catheter is the Foley, which is made from natural or synthetic rubber. Foley catheters are passed into the bladder via the urethra or the suprapubic puncture channel (through the abdominal wall). A simulator for the abdominal w...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Coveney VA,Gröver D

    更新日期:2001-08-01 00:00:00

  • Wearable sensors for patient-specific boundary shape estimation to improve the forward model for electrical impedance tomography (EIT) of neonatal lung function.

    abstract::Electrical impedance tomography (EIT) could be significantly advantageous to continuous monitoring of lung development in newborn and, in particular, preterm infants as it is non-invasive and safe to use within the intensive care unit. It has been demonstrated that accurate boundary form of the forward model is import...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Khor JM,Tizzard A,Demosthenous A,Bayford R

    更新日期:2014-06-01 00:00:00

  • Potential neuroprotective effects of acupuncture stimulation on diabetes mellitus in a global ischemic rat model.

    abstract::Acupuncture (ACU) is known to be effective in ischemia treatment, and glutamate (GLU) excitotoxicity is an important factor in neuronal cell death. We observed the effect of ACU on cerebral blood flow (%CBF) and DeltaGLU (the changes in GLU release) in the ischemic stroke rat model of diabetic mellitus (DM). A global ...

    journal_title:Physiological measurement

    pub_type: 杂志文章


    authors: Choi S,Lee GJ,Chae SJ,Kang SW,Yin CS,Lee SH,Choi SK,Park HK

    更新日期:2010-05-01 00:00:00