Abstract:
BACKGROUND:Hyperuricemia is an established risk factor for cardiovascular events and mortality. This study investigated the association between serum uric acid and the incidence of nonfatal stroke in a Japanese community-based population. METHODS:We used a nationwide database of 155,322 subjects (aged 40-73, male 39 %) who participated in the annual "Specific Health Check and Guidance in Japan" checkup from 2008 to 2010. We examined the relationship between the quintiles of serum uric acid levels at baseline and the incidence of nonfatal stroke during a 2-year study period using self-reported data. RESULTS:The crude incidence of nonfatal stroke was significantly associated with serum uric acid levels at baseline, showing the lowest values in subjects with the 3rd quintile (Q3: men, 5.0-5.6; women, 3.8-4.3) of uric acid levels (mg/dL) and the highest values in subjects with the highest quintile (Q5: men ≥7.1, women ≥5.5) both in men and women (P < 0.05). In multivariate-adjusted logistic regression analysis, the odds ratio (OR) of the Q5 group was significantly higher than for the Q3 group in both men and women [men: OR 1.26, 95 % confidence interval (CI) 1.04-1.54, women: OR 1.24, 95 % CI 1.00-1.48]. In the subgroup analysis, the OR of the Q5 group of uric acid levels for incident stroke was high, irrespective of characteristics such as age, sex, and renal function. CONCLUSIONS:This study has shown that serum uric acid is independently associated with the incidence of nonfatal stroke in the general Japanese population.
journal_name
Clin Exp Nephroljournal_title
Clinical and experimental nephrologyauthors
Kamei K,Konta T,Hirayama A,Ichikawa K,Kubota I,Fujimoto S,Iseki K,Moriyama T,Yamagata K,Tsuruya K,Narita I,Kondo M,Shibagaki Y,Kasahara M,Asahi K,Watanabe Tdoi
10.1007/s10157-016-1311-7subject
Has Abstractpub_date
2017-06-01 00:00:00pages
497-503issue
3eissn
1342-1751issn
1437-7799pii
10.1007/s10157-016-1311-7journal_volume
21pub_type
杂志文章abstract:BACKGROUND:The risk of developing CKD is increased in HIV-infected patients; however, the relationship between renal function decline and lipid abnormalities currently remains unclear in these patients. METHODS:A retrospective cohort study was conducted on 661 HIV-infected patients, whose estimated glomerular filtrati...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-016-1281-9
更新日期:2017-04-01 00:00:00
abstract::Lipoprotein glomerulopathy (LPG) is a rare hereditary disease characterized by the accumulation of much thrombi material consisting of lipoproteins at the glomerular capillary lumen. Most patients show nephrotic syndrome; nearly half progress to chronic renal failure. Intensive therapy with lipid-lowering agents repor...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-009-0207-1
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Children with nephrotic syndrome (NS) have hyperlipidemia, which may lead to endothelial dysfunction. This study evaluated endothelial function and structural atherosclerosis in NS children with disease duration more than 2 years, by assessment of brachial artery flow-mediated dilatation (FMD) and carotid in...
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doi:10.1007/s10157-014-0958-1
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abstract:BACKGROUND AND OBJECTIVES:Data regarding renal disease in the elderly (age ≥65 years old) and very elderly (age ≥80 years old) Japanese are extremely limited. The aim of this study was to examine the causes of renal disease and their clinical presentations in elderly patients who underwent renal biopsy. DESIGN, SETTIN...
journal_title:Clinical and experimental nephrology
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doi:10.1007/s10157-012-0673-8
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abstract:BACKGROUND:Autosomal dominant polycystic disease (ADPKD) often results in renal failure. Recently, allelic influences of PKD1 mutation types on renal survival were extensively investigated. Here, we analyzed integrated influences of PKD1 mutation types and positions on renal survival. METHODS:We included 338 (82 pedig...
journal_title:Clinical and experimental nephrology
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abstract:BACKGROUND:Achieving a normal final adult height (FH) remains a challenge in the field of pediatric kidney transplantation (KTx). To examine the optimal approach to assuring normal FH following KTx, we retrospectively examined the post-transplant growth and FH of pediatric KTx recipients. METHODS:Since the relevant fa...
journal_title:Clinical and experimental nephrology
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journal_title:Clinical and experimental nephrology
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journal_title:Clinical and experimental nephrology
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journal_title:Clinical and experimental nephrology
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,多中心研究
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更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Because of the well-established annual urinalysis screening system in Japan, the duration of nephropathy (DN) can be estimated in more than half of all patients with IgA nephropathy (IgAN). Treatment using a combination of tonsillectomy and steroid pulse (TSP) therapy has been reported as an effective method...
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journal_title:Clinical and experimental nephrology
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
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更新日期:2004-03-01 00:00:00
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更新日期:2011-02-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
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