Different association of cigarette smoking with GFR estimated from serum creatinine and that from serum cystatin C in the general population.

abstract：BACKGROUND:Cirrhosis of the liver is often associated with an impairment of renal function that is usually not associated with consistent structural abnormalities of the renal parenchyma, but is thought to be the functional consequence of arterial underfilling and reduced arterial blood pressure. METHOD:We have used t...

journal_title：Clinical and experimental nephrology

authors： Maoka T,Kawata T,Koike T,Mochizuki T,Schnermann J,Hashimoto S

更新日期：2018-10-01 00:00:00

abstract：:Waldenström's macroglobulinemia is rare lymphoproliferative disorder characterized by the presence of a monoclonal IgM paraproteinemia. Cryoglobulinemia is a common sequela of Waldenström's macroglobulinemia present in 8-18% of the patients. Cryoglobulinemia has also been described as occurring after treatment with ri...

journal_title：Clinical and experimental nephrology

authors： Shaikh A,Habermann TM,Fidler ME,Kumar S,Leung N

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Renin-angiotensin system blockers (RASBs) reduce end-stage kidney disease and cardiovascular event (CVE) development in chronic kidney disease. However, whether RASBs improve long-term prognosis in kidney transplant (KT) recipients remain unknown. METHOD:We investigated 900 kidney transplant patients in a m...

journal_title：Clinical and experimental nephrology

authors： Tsuchimoto A,Masutani K,Ueki K,Nakagawa K,Matsukuma Y,Tanaka S,Unagami K,Kakuta Y,Okumi M,Noguchi H,Kaku K,Okabe Y,Nakano T,Kitazono T,Nakamura M,Ishida H,Tanabe K,Japan Academic Consortium of Kidney Transplantation (JA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct. Multiple phosphorylation sites are present at the C-terminal of AQP2 including S256 (serine at 256 residue), S261, S264 and S/T269, which are regulated by vasopressin (VP) to modulate AQP2 traffi...

journal_title：Clinical and experimental nephrology

authors： Sakai M,Yamamoto K,Mizumura H,Matsumoto T,Tanaka Y,Noda Y,Ishibashi K,Yamamoto T,Sasaki S

更新日期：2020-09-01 00:00:00

abstract：:Recently, there has been a paradigm shift away from an emphasis on the role of the endocrine (circulating) renin-angiotensin system (RAS) in the regulation of the sodium and extracellular fluid balance, blood pressure, and the pathophysiology of hypertensive organ damage toward a focus on the role of tissue RAS found ...

journal_title：Clinical and experimental nephrology

authors： Kagami S

更新日期：2012-04-01 00:00:00

abstract：:Ischemia-reperfusion injury is a main cause of acute kidney injury. Tubular necrosis and interstitial inflammatory cell infiltration are characteristic pathologic changes of acute kidney injury. The main necrotic area should be repaired with new tubular epithelial cells after the injury. On the other hand, some parts ...

journal_title：Clinical and experimental nephrology

authors： Furuichi K,Kaneko S,Wada T

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:Myeloid-derived suppressor cells (MDSCs) have been identified as immunosuppressive cells in tumor-related inflammation. However, the pathogenesis of MDSCs for autoimmune disease has not been investigated as yet. The aim of this study was to address whether MDSCs contribute to autoimmune organ injury in lupus-...

journal_title：Clinical and experimental nephrology

authors： Iwata Y,Furuichi K,Kitagawa K,Hara A,Okumura T,Kokubo S,Shimizu K,Sakai N,Sagara A,Kurokawa Y,Ueha S,Matsushima K,Kaneko S,Wada T

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Previous studies reported that children with neural tube defects, but without any history of intrinsic renal diseases, have small kidneys when compared with age-matched standard renal growth. The aim of this study was to investigate the possible causes of small renal size in children with spina bifida by com...

journal_title：Clinical and experimental nephrology

authors： Montaldo P,Montaldo L,Iossa AC,Cennamo M,Caredda E,Del Gado R

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Mortality in the first year of maintenance dialysis is higher than in subsequent years and, within this first year, the risk of death is highest in the first 90 days. Some studies have shown that pre-dialysis education reduces early mortality. Limited data have been published from South Africa regarding earl...

journal_title：Clinical and experimental nephrology

authors： Fabian J,Van Jaarsveld K,Maher HA,Gaylard P

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Low health literacy (HL) has been associated with poor chronic disease management and adverse outcomes. However, reports on HL in predialysis chronic kidney disease (CKD) patients are limited in Japan. METHODS:From August 2019 to February 2020, the European Health Literacy Survey (Japanese version) and a pa...

journal_title：Clinical and experimental nephrology

authors： Kita Y,Machida S,Shibagaki Y,Sakurada T

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is a common complication in critically ill patients. Urinary excretion of liver-type fatty acid-binding protein (L-FABP), which is expressed in the proximal tubules, reflects the presence of tubular injury. Urinary excretion of podocalyxin (PCX), a glycoprotein prominently expressed...

journal_title：Clinical and experimental nephrology

authors： Matsui K,Kamijo-Ikemori A,Hara M,Sugaya T,Kodama T,Fujitani S,Taira Y,Yasuda T,Kimura K

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Albuminuria is a biomarker for chronic kidney disease and an independent predictor of cardiovascular and all-cause mortality. A recent meta-analysis concluded that these risks increase with urinary albumin concentration, even when below the microalbuminuria threshold. Thus, minimizing urinary albumin may be ...

journal_title：Clinical and experimental nephrology

authors： Yamamoto-Kabasawa K,Hosojima M,Yata Y,Saito M,Tanaka N,Tanaka J,Tanabe N,Narita I,Arakawa M,Saito A

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Darbepoetin alfa (DA) is an attractive alternative to recombinant human erythropoietin (rHuEPO) in managing renal anemia. Since DA has not been approved by the appropriate Japanese drug regulatory agencies for the indication of renal anemia in children in Japan, we have conducted a multicenter prospective st...

journal_title：Clinical and experimental nephrology

authors： Hattori M,Matsunaga A,Akioka Y,Fujinaga S,Nagai T,Uemura O,Nakakura H,Ashida A,Kamei K,Ito S,Yamada T,Goto Y,Ohta T,Hisano M,Komatsu Y,Itami N

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 (CoQ10). METHODS:Three-week-old heminephrectomized male Sprague-Dawley rats were divided into three groups (10 animals each): diet with normal (0.3%) salt, high (8%) salt, and high salt plus 60...

journal_title：Clinical and experimental nephrology

authors： Ishikawa A,Kawarazaki H,Ando K,Fujita M,Fujita T,Homma Y

更新日期：2011-02-01 00:00:00

abstract：:We describe here two sisters with nephronophthisis, which was not detected until the development of endstage renal failure. Twenty- and 15-year-old female siblings were admitted to our hospital for further examination of renal dysfunction. No urinalysis abnormalities had been found in yearly health checks in either pa...

journal_title：Clinical and experimental nephrology

authors： Ashizawa M,Miyazaki M,Furusu A,Abe K,Kanamoto Y,Iwanaga N,Ozono Y,Harada T,Taguchi T,Kohno S

更新日期：2005-12-01 00:00:00

abstract：:The manifestation of diabetic nephropathy may be a consequence of the actions of certain cytokines and growth factors. Prominent among them is transforming growth factor-β (TGF-β), which promotes renal cell hypertrophy and stimulates extracellular matrix accumulation, the two hallmarks of diabetic renal disease. In ex...

journal_title：Clinical and experimental nephrology

authors： Ziyadeh FN,Isono M,Chen S

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a common disease, affecting about 10% of the general population. The genetic component about CKD incidence in Asian population is not well known. The aim of the study is to find the genetic loci associated with incident CKD and to figure out the effect of genetic variation on ...

journal_title：Clinical and experimental nephrology

authors： Yun S,Han M,Kim HJ,Kim H,Kang E,Kim S,Ahn C,Oh KH

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Intravascular administration of iodinated contrast media continues to be a common cause of hospital-acquired acute kidney injury. Accumulating evidence suggests that radiocontrast agent-induced nephrotoxicity is associated with increased oxidative stress, which leads to renal tissue damage with DNA fragmenta...

journal_title：Clinical and experimental nephrology

authors： Ludwig U,Connemann J,Keller F

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Dotinurad is a novel, selective urate reabsorption inhibitor (SURI), which reduces serum uric acid levels by selective inhibition of the urate transporter 1 (URAT1). The Japanese guideline for the management of hyperuricemia and gout recommends that drug selection should be based on classification of hyperur...

journal_title：Clinical and experimental nephrology

authors： Hosoya T,Furuno K,Kanda S

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The Stewart model for analyzing acid-base disturbances emphasizes serum albumin levels, which are ignored in the traditional Boston model. We compared data derived using the Stewart model to those using the Boston model in patients with nephrotic syndrome. METHODS:Twenty-nine patients with nephrotic syndrom...

journal_title：Clinical and experimental nephrology

authors： Kasagi T,Imai H,Miura N,Suzuki K,Yoshino M,Nobata H,Nagai T,Banno S

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The definition of sepsis was updated to sepsis-3 in February 2016. Currently, direct hemoperfusion therapy using the polymyxin B-immobilized fiber cartridge (PMX-DHP) is widely performed to treat sepsis and septic shock. However, the prognostic factors of PMX-DHPs in patients with sepsis using the new defini...

journal_title：Clinical and experimental nephrology

authors： Okubo A,Nakashima A,Doi S,Ueno T,Sasaki K,Esaki T,Masaki T

更新日期：2018-10-01 00:00:00

abstract：:Distal renal tubular acidosis (dRTA) results from impaired urinary acidification by the renal collecting duct. Acquired dRTA can be secondary to diverse pathological processes, including diabetic, ischemic, fibrosing, or immunological processes; less frequently it presents as a familial disorder with either an autosom...

journal_title：Clinical and experimental nephrology

authors： Shayakul C,Alper SL

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:Skin and soft tissue infection (SSTI) is the most common of infectious diseases with high morbidity and mortality. However, the clinical characteristics of SSTI in patients with nephrotic syndrome (NS), especially in those patients who received immunosuppressive therapy, are still lacking. The present study w...

journal_title：Clinical and experimental nephrology

authors： Hu T,Wang M,Chen W,Zhao J,Xiong J

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND AIM:The infusion of chronic angiotensin II (Ang II) has been shown to promote renal interstitial fibrosis. To evaluate the pathophysiological significance of the natriuretic peptide-GC-A system, we infused Ang II (1.0 mg/kg/day) in GC-A-deficient mice (GC-A-KO). METHODS:We used 5 groups (Wild-Saline n =...

journal_title：Clinical and experimental nephrology

authors： Yoshihara F,Tokudome T,Kishimoto I,Otani K,Kuwabara A,Horio T,Kawano Y,Kangawa K

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Ambulatory blood pressure (ABP) monitoring and carotid-femoral pulse wave velocity (cfPWV) provide important cardiovascular risk information for dialysis patients. This study aims to evaluate the risk factors of cfPWV and the associations between ambulatory blood pressure, especially night-time blood pressur...

journal_title：Clinical and experimental nephrology

authors： Li X,Jiang Q,Wu W,Xu X,Miao L,Jin L,Xue L,Huang T,Di J,Liu J,He X

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The incidence of childhood nephrotic syndrome (NS) in Germany is not well known. METHODS:An ESPED-based nationwide collection of epidemiological data of children in 2005 and 2006. RESULT:The mean age of NS at onset was 5.5 ± 3.7 years. The gender ratio of boys to girls was 1.8:1. The average length of stay...

journal_title：Clinical and experimental nephrology

authors： Franke I,Aydin M,Llamas Lopez CE,Kurylowicz L,Ganschow R,Lentze M,Born M

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Although several studies have investigated the relationship between dietary nutrient intake and microalbuminuria, no study of an Asian population has been reported. The present study investigates the relationship between dietary intake and microalbuminuria in a general Japanese population. METHODS:We analyz...

journal_title：Clinical and experimental nephrology

authors： Sato M,Hozawa A,Konta T,Shao L,Otani K,Narimatsu H,Sasaki S,Kato T,Kubota I,Yamashita H,Kayama T,Fukao A

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Creatinine clearance (Ccr) overestimates glomerular filtration rate (GFR) due to the tubular secretion of creatinine. It is known that fractional excretion of creatinine (FE-Cr) increases with decreasing GFR. Association of serum albumin level with the tubular secretion of creatinine was also reported previo...

journal_title：Clinical and experimental nephrology

authors： Horio M,Imai E,Yasuda Y,Watanabe T,Matsuo S

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Autosomal dominant polycystic disease (ADPKD) often results in renal failure. Recently, allelic influences of PKD1 mutation types on renal survival were extensively investigated. Here, we analyzed integrated influences of PKD1 mutation types and positions on renal survival. METHODS:We included 338 (82 pedig...

journal_title：Clinical and experimental nephrology

authors： Higashihara E,Horie S,Kinoshita M,Harris PC,Okegawa T,Tanbo M,Hara H,Yamaguchi T,Shigemori K,Kawano H,Miyazaki I,Kaname S,Nutahara K

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The Japanese classification of diabetic nephropathy reflects the risks of mortality, cardiovascular events and kidney prognosis and is clinically useful. Furthermore, pathological findings of diabetic nephropathy are useful for predicting prognoses. In this study, we evaluated the characteristics of patholog...

journal_title：Clinical and experimental nephrology

authors： Furuichi K,Shimizu M,Yuzawa Y,Hara A,Toyama T,Kitamura H,Suzuki Y,Sato H,Uesugi N,Ubara Y,Hohino J,Hisano S,Ueda Y,Nishi S,Yokoyama H,Nishino T,Kohagura K,Ogawa D,Mise K,Shibagaki Y,Makino H,Matsuo S,Wada T,

更新日期：2018-06-01 00:00:00