The incidence of the nephrotic syndrome in childhood in Germany.

Abstract:

BACKGROUND:The incidence of childhood nephrotic syndrome (NS) in Germany is not well known. METHODS:An ESPED-based nationwide collection of epidemiological data of children in 2005 and 2006. RESULT:The mean age of NS at onset was 5.5 ± 3.7 years. The gender ratio of boys to girls was 1.8:1. The average length of stay was 15.5 ± 11.2 days, with younger children remaining significantly longer in hospital. Steroid-resistance was more common in children ≥8 years (p = 0.023). Focal-segmental glomerulosclerosis (FSGS) was more common in children >10 years (p = 0.029). The ratio of males to females with FSGS was 1:1.9, thus the FSGS risk for girls at onset was 3.3-times greater. Considering the available data, the incidence of NS in Germany is 1.2/100,000 in the population <18 years, of which 1.0/100,000 are steroid-sensitive. CONCLUSION:Compared with international data, which primarily focused on regional and small populations, this is the largest study about the incidence of the childhood NS.

journal_name

Clin Exp Nephrol

authors

Franke I,Aydin M,Llamas Lopez CE,Kurylowicz L,Ganschow R,Lentze M,Born M

doi

10.1007/s10157-017-1433-6

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

126-132

issue

1

eissn

1342-1751

issn

1437-7799

pii

10.1007/s10157-017-1433-6

journal_volume

22

pub_type

杂志文章
  • Steroids and azathioprine in the treatment of IgA nephropathy.

    abstract:AIM:IgA nephropathy (IgAN) is a very common glomerulonephritis among young adults, but the best therapeutic approach has not been fully elucidated. This study evaluated the effect of two different treatment regimes in IgAN, steroids alone or in combination with azathioprine. METHODS:Among 122 patients with primary IgA...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10157-011-0415-3

    authors: Stangou M,Ekonomidou D,Giamalis P,Liakou H,Tsiantoulas A,Pantzaki A,Papagianni A,Efstratiadis G,Alexopoulos E,Memmos D

    更新日期:2011-06-01 00:00:00

  • Assessment of tubular reabsorption of phosphate as a surrogate marker for phosphate regulation in chronic kidney disease.

    abstract:BACKGROUND/AIMS:Fibroblast growth factor 23 (FGF23) and soluble α-Klotho are emerging potential biomarkers of phosphorus and vitamin D metabolism which change in concentration in early chronic kidney disease (CKD) in order to maintain normal phosphorus levels. Tubular reabsorption of phosphate (TRP) has been commonly u...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-014-0962-5

    authors: Hong YA,Lim JH,Kim MY,Kim Y,Yang KS,Chung BH,Chung S,Choi BS,Yang CW,Kim YS,Chang YS,Park CW

    更新日期:2015-04-01 00:00:00

  • Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation.

    abstract:BACKGROUND:Injection of parathyroid hormone (PTH) rapidly stimulates renal Pi excretion, in part by downregulating NaPi-IIa (Npt2a/SLC34A1) and NaPi-IIc (Npt2c/SLC34A3) transporters. The mechanisms underlying the effects of PTH on NaPi-IIc are not fully elucidated. METHODS:We analyzed the effect of PTH on inorganic ph...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01725-6

    authors: Fujii T,Segawa H,Hanazaki A,Nishiguchi S,Minoshima S,Ohi A,Tominaga R,Sasaki S,Tanifuji K,Koike M,Arima Y,Shiozaki Y,Kaneko I,Ito M,Tatsumi S,Miyamoto KI

    更新日期:2019-07-01 00:00:00

  • The effect for hyperuricemia inpatient of uric acid overproduction type or in combination with topiroxostat on the pharmacokinetics, pharmacodynamics and safety of dotinurad, a selective urate reabsorption inhibitor.

    abstract:BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor (SURI), increases urinary uric acid excretion. The aim of this study is to examine the pharmacokinetics, pharmacodynamics, and safety of dotinurad according to the type of hyperuricemia, with or without concomitant use of xanthine oxidase inhibitor, i...

    journal_title:Clinical and experimental nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10157-019-01817-3

    authors: Okui D,Sasaki T,Fushimi M,Ohashi T

    更新日期:2020-03-01 00:00:00

  • The effects of raloxifene on bone turnover markers and bone mineral density in women on maintenance hemodialysis.

    abstract:BACKGROUND:Bone disease is caused not only by increased bone turnover accompanying secondary hyperparathyroidism but also by factors such as bone metabolic disorder accompanying kidney disease and postmenopausal or age-related osteoporosis in hemodialysis patients. In this study, we investigated the effects of raloxife...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-010-0366-0

    authors: Saito O,Saito T,Asakura S,Sugase T,Ito C,Ando Y,Muto S,Kusano E

    更新日期:2011-02-01 00:00:00

  • Cardiorenal syndrome: still not a defined entity.

    abstract::Because of the increasing incidence of cardiac failure and chronic renal failure due to the progressive aging of the population, the extensive application of cardiac interventional techniques, the rising rates of obesity and diabetes mellitus, coexistence of heart failure and renal failure in the same patient are freq...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s10157-009-0257-4

    authors: Longhini C,Molino C,Fabbian F

    更新日期:2010-02-01 00:00:00

  • Dotinurad: a clinical pharmacokinetic study of a novel, selective urate reabsorption inhibitor in subjects with hepatic impairment.

    abstract:BACKGROUND:Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by inhibiting the urate transporter 1 (URAT1). We compared the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotinurad in subjects with hepatic impairment and normal hepatic function. METHODS:Thi...

    journal_title:Clinical and experimental nephrology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s10157-019-01816-4

    authors: Kumagai Y,Sakaki M,Furihata K,Ito T,Inoue K,Yoshida T,Matsumoto S,Furuno K,Hagino A

    更新日期:2020-03-01 00:00:00

  • The relationship between renal volume and renal function in autosomal dominant polycystic kidney disease.

    abstract:BACKGROUND:In patients with autosomal dominant polycystic kidney disease (ADPKD), renal cysts grow exponentially. Since remaining renal parenchyma has a capacity to compensate for the loss of glomerular filtration, the glomerular filtration rate (GFR) may be sustained until the disease progresses. The purpose of this s...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-011-0428-y

    authors: Tokiwa S,Muto S,China T,Horie S

    更新日期:2011-08-01 00:00:00

  • Significance of the duration of nephropathy for achieving clinical remission in patients with IgA nephropathy treated by tonsillectomy and steroid pulse therapy.

    abstract:BACKGROUND:Because of the well-established annual urinalysis screening system in Japan, the duration of nephropathy (DN) can be estimated in more than half of all patients with IgA nephropathy (IgAN). Treatment using a combination of tonsillectomy and steroid pulse (TSP) therapy has been reported as an effective method...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-011-0530-1

    authors: Ieiri N,Hotta O,Sato T,Taguma Y

    更新日期:2012-02-01 00:00:00

  • Cystic renal cell carcinoma, suspected because of lack of regression of renal cysts after renal transplantation in a dialysis patient with acquired renal cystic disease.

    abstract::A 34-year-old man who had been on dialysis for about 6 years, and had acquired renal cystic disease, received a renal transplantation. However, in spite of the success of the transplantation, one area without cyst regression was observed in the original kidney. Therefore, carcinoma was suspected and nephrectomy was pe...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s101570300013

    authors: Ishikawa I,Saito A,Chikazawa Y,Asaka M,Tomosugi N,Yuri T,Suzuki K,Ueda Y,Ozaki M

    更新日期:2003-03-01 00:00:00

  • Hypertensive encephalopathy in patients with chronic renal failure caused by stopping antihypertensive agents: a report of two cases.

    abstract::We herein report two cases of patients with chronic kidney disease who developed hypertensive encephalopathy, which occurred after a sudden discontinuance of antihypertensive agents. Both patients underwent care at our hospital after experiencing neurological abnormalities. In both patients, magnetic resonance imaging...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s10157-009-0252-9

    authors: Nakabou M,Kai T,Maeshima T,Kanamasa K

    更新日期:2010-06-01 00:00:00

  • Involvement of glomerular renin-angiotensin system (RAS) activation in the development and progression of glomerular injury.

    abstract::Recently, there has been a paradigm shift away from an emphasis on the role of the endocrine (circulating) renin-angiotensin system (RAS) in the regulation of the sodium and extracellular fluid balance, blood pressure, and the pathophysiology of hypertensive organ damage toward a focus on the role of tissue RAS found ...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s10157-011-0568-0

    authors: Kagami S

    更新日期:2012-04-01 00:00:00

  • Aggravated renal tubular damage and interstitial fibrosis in mice lacking guanylyl cyclase-A (GC-A), a receptor for atrial and B-type natriuretic peptides.

    abstract:BACKGROUND AND AIM:The infusion of chronic angiotensin II (Ang II) has been shown to promote renal interstitial fibrosis. To evaluate the pathophysiological significance of the natriuretic peptide-GC-A system, we infused Ang II (1.0 mg/kg/day) in GC-A-deficient mice (GC-A-KO). METHODS:We used 5 groups (Wild-Saline n =...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-014-0982-1

    authors: Yoshihara F,Tokudome T,Kishimoto I,Otani K,Kuwabara A,Horio T,Kawano Y,Kangawa K

    更新日期:2015-04-01 00:00:00

  • Association between cystatin C and inflammation in patients with essential hypertension.

    abstract:BACKGROUND:Serum cystatin C is not only a marker of renal function but also acts as an independent risk factor for cardiovascular damage, heart failure, and death. It is known that the initiation and progression of these cardiovascular events contributes to renal dysfunction and chronic inflammation. In this study, we ...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-010-0334-8

    authors: Okura T,Jotoku M,Irita J,Enomoto D,Nagao T,Desilva VR,Yamane S,Pei Z,Kojima S,Hamano Y,Mashiba S,Kurata M,Miyoshi K,Higaki J

    更新日期:2010-12-01 00:00:00

  • Suppression of parathyroid hormone secretion in CAPD patients by intraperitoneal administration of Maxacalcitol.

    abstract:BACKGROUND:Maxacalcitol (22-oxacalcitriol; OCT) is a novel vitamin D analogue. In previous clinical studies, OCT was administered three times a week to hemodialysis patients with refractory secondary hyperparathyroidism (2HPT), in whom it acted by inhibiting parathyroid hormone secretion, as well as causing mildly elev...

    journal_title:Clinical and experimental nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10157-004-0283-1

    authors: Murakami K,Miyachi H,Watanabe A,Kawamura N,Fujii M,Koide S,Murase M,Kushimoto H,Hasegawa M,Tomita M,Hiki Y,Sugiyama S

    更新日期:2004-06-01 00:00:00

  • Utility and feasibility of a new programmable home blood pressure monitoring device for the assessment of nighttime blood pressure.

    abstract:BACKGROUND:Recent evidence indicates that both ambulatory blood pressure monitoring (ABPM) and home blood pressure monitoring (HBPM) are more useful than the measurement of office blood pressure for evaluating cardiovascular risks in subjects with hypertension. The major advantage of ABPM over HBPM is the ability to me...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-009-0192-4

    authors: Ushio H,Ishigami T,Araki N,Minegishi S,Tamura K,Okano Y,Uchino K,Tochikubo O,Umemura S

    更新日期:2009-10-01 00:00:00

  • Determinants for the prognosis of acute renal disorders that developed during or after treatment with edaravone.

    abstract:BACKGROUND:Edaravone, a drug for treating acute ischemic stroke, has been reported to provoke acute renal disorders. In the previous study, the author evaluated the role of edaravone in the development of renal disorders in 207 patients reported as having developed them in the post-marketing survey of the drug. The ove...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-008-0108-8

    authors: Hishida A

    更新日期:2009-04-01 00:00:00

  • The choice of comorbidity scoring system in Chinese peritoneal dialysis patients.

    abstract:BACKGROUND:Several comorbidity scoring systems have been developed and validated, mostly in western hemodialysis patients with a high risk of cardiovascular disease. The performance of comorbidity scoring, however, depends on the patient population. In this study, we determine the optimal comorbidity scoring system for...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-017-1418-5

    authors: Ma TK,Chow KM,Kwan BC,Ng JK,Pang WF,Leung CB,Li PK,Szeto CC

    更新日期:2018-02-01 00:00:00

  • Nilvadipine attenuates mesangial expansion and glomerular hypertrophy in diabetic db/db mice, a model for type 2 diabetes.

    abstract:BACKGROUND:The renoprotection achieved by angiotensin II blockade in the treatment of diabetic nephropathy is well established in both the clinical and the experimental settings. In contrast, the therapeutic efficacy of calcium channel blockers (CCBs) in the treatment of diabetic nephropathy still remains controversial...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-004-0303-1

    authors: Moriyama T,Oka K,Ueda H,Imai E

    更新日期:2004-09-01 00:00:00

  • Mutation analyses by next-generation sequencing and multiplex ligation-dependent probe amplification in Japanese autosomal dominant polycystic kidney disease patients.

    abstract:BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD), one of the most common hereditary kidney diseases, causes gradual growth of cysts in the kidneys, leading to renal failure. Owing to the advanced technology of next-generation sequencing (NGS), genetic analyses of the causative genes PKD1 and PKD2 have be...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01736-3

    authors: Mochizuki T,Teraoka A,Akagawa H,Makabe S,Akihisa T,Sato M,Kataoka H,Mitobe M,Furukawa T,Tsuchiya K,Nitta K

    更新日期:2019-08-01 00:00:00

  • Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: randomized, multicenter, double-blind, placebo-controlled, parallel-group, confirmatory phase 2 study.

    abstract:BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor (SURI), reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1) for the treatment of hyperuricemia with or without gout. We confirmed the serum uric acid lowering effect and safety of dotinurad. METHODS:This was a confirm...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s10157-019-01818-2

    authors: Hosoya T,Sano T,Sasaki T,Fushimi M,Ohashi T

    更新日期:2020-03-01 00:00:00

  • A case of angiomyolipoma of the renal sinus.

    abstract::The case of a 63-year-old woman with a relatively rapidly growing angiomyolipoma (AML) originating from the right renal sinus is presented. The tumor had enlarged to more than fivefold in volume (7.4 × 6.7 × 10.1 cm) in the 7 years following its detection (5.6 × 3.4 × 4.6 cm) and had significantly pushed aside the duo...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-011-0519-9

    authors: Shirotake S,Yoshimura I,Kosaka T,Matsuzaki S

    更新日期:2011-12-01 00:00:00

  • Risk of macrovascular disease stratified by stage of chronic kidney disease in type 2 diabetic patients: critical level of the estimated glomerular filtration rate and the significance of hyperuricemia.

    abstract:BACKGROUND:Although a high prevalence of macrovascular disease (MVD) has been reported in patients with stage 3 chronic kidney disease (CKD), few studies have reported its risk with respect to the underlying cause of kidney disease. This study investigated the prevalence of MVD in type 2 diabetic patients with CKD stra...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-011-0420-6

    authors: Tanaka K,Hara S,Kushiyama A,Ubara Y,Yoshida Y,Mizuiri S,Aikawa A,Kawatzu S

    更新日期:2011-06-01 00:00:00

  • Adrenomedullin (AM) and receptor-activity-modifying proteins in glomeruli with Thy.1 glomerulonephritis.

    abstract:BACKGROUND:Adrenomedullin (AM) has antiproliferative and proapoptotic effects on mesangial cells in culture, but the regulation of AM and its receptors in glomeruli with glomerulonephritis have not been clarified. METHODS:We examined sequential changes in the mRNA expression of AM and its receptors (receptor-activity-...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-004-0309-8

    authors: Matsumoto M,Fujimoto S,Iwatsubo S,Sato Y,Hara S,Kitamura K,Eto T

    更新日期:2004-12-01 00:00:00

  • Suppression of experimental crescentic glomerulonephritis by peroxisome proliferator-activated receptor (PPAR)gamma activators.

    abstract:BACKGROUND:It has been recently reported that peroxisome proliferator-activated receptors (PPARs)gamma exist in various tissues and that they exibit anti-inflammatory effects. METHODS:We investigated the effects of PPARgamma activators on the development of crescentic glomerulonephritis. Crescentic glomerulonephritis ...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s101570300003

    authors: Haraguchi K,Shimura H,Onaya T

    更新日期:2003-03-01 00:00:00

  • IgM-immune complex glomerulonephritis associated with sarcoidosis.

    abstract::We present a case of proliferative glomerulonephritis with peculiar IgM deposition associated with sarcoidosis. A 62-year-old woman, who had been diagnosed with sarcoidosis 3 years previously because of abnormalities on chest X-ray radiophotographs and lymph node pathology, was admitted to our hospital for the evaluat...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-005-0390-7

    authors: Kanamori H,Ota M,Takeoka H,Osafune K,Yonezu S,Fukatsu A,Kanatsu K

    更新日期:2006-03-01 00:00:00

  • Olmesartan clinical trial in Okinawan patients under OKIDS (OCTOPUS) study: design and methods.

    abstract:BACKGROUND:Guidelines for treatment of hypertension are not available for chronic hemodialysis (HD) population, despite the high mortality rate due to cardiovascular disease (CVD). Survival is much better among hypertensive patients than normal to hypotensive patients. Target levels of blood pressure and the class of a...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10157-008-0116-8

    authors: Iseki K,Tokuyama K,Shiohira Y,Higa A,Hirano H,Toma S,Kohagura K,Ueda S

    更新日期:2009-04-01 00:00:00

  • Elevation of creatine kinase is associated with acute kidney injury in hospitalized patients infected with seasonal influenza virus.

    abstract:BACKGROUND:Although acute kidney injury (AKI) is known as a potential complication of influenza infections, there is limited information concerning the association between influenza and AKI. The aim of this study is to evaluate the incidence, the mortality, and risk factors of AKI in hospitalized patients by seasonal i...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-020-02006-3

    authors: Ishibuchi K,Fukasawa H,Kaneko M,Yasuda H,Furuya R

    更新日期:2021-01-04 00:00:00

  • A patient undergoing chronic dialysis whose renal anemia was successfully corrected by treatment with cinacalcet.

    abstract::A 62-year-old female dialysis patient with chronic glomerulonephritis had been receiving hemodialysis therapy for 32 years. In 1985 she underwent a parathyroidectomy for secondary hyperparathyroidism (HPT); however, her parathyroid hormone (PTH) levels gradually increased. Her serum calcium level ranged from 9.0 to 10...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-011-0433-1

    authors: Oshiro Y,Tanaka H,Okimoto N

    更新日期:2011-08-01 00:00:00

  • Rituximab for nephrotic syndrome in children.

    abstract::Idiopathic nephrotic syndrome is the most common chronic glomerular disease in children. At least 20 % of children with this syndrome show frequent relapses and/or steroid dependence during or after immunosuppressive therapies, a condition defined as complicated frequently relapsing/steroid-dependent nephrotic syndrom...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s10157-016-1313-5

    authors: Iijima K,Sako M,Nozu K

    更新日期:2017-04-01 00:00:00