pH after the first session of direct hemoperfusion with polymyxin B-immobilized fibers predicts mortality in patients with sepsis and septic shock.

abstract：BACKGROUND:Chronic kidney disease (CKD) is a significant public health problem. Strategy for its early detection is still controversial. This study aims to assess the cost-effectiveness of population strategy, i.e. mass screening, and Japan's health checkup reform. METHODS:Cost-effectiveness analysis was carried out t...

journal_title：Clinical and experimental nephrology

authors： Kondo M,Yamagata K,Hoshi SL,Saito C,Asahi K,Moriyama T,Tsuruya K,Yoshida H,Iseki K,Watanabe T

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Both myeloperoxidase-associated antineutrophil cytoplasmic antibody (MPO-ANCA) and antiglomerular basement membrane antibody (anti-GBM Ab) positivity have been demonstrated in patients with rapidly progressive glomerulonephritis (RPGN), either with or without pulmonary hemorrhage; however, the implications o...

journal_title：Clinical and experimental nephrology

authors： Nakabayashi K,Fujioka Y,Nagasawa T,Kimura T,Kojima K,Arimura Y,Yamada A

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct. Multiple phosphorylation sites are present at the C-terminal of AQP2 including S256 (serine at 256 residue), S261, S264 and S/T269, which are regulated by vasopressin (VP) to modulate AQP2 traffi...

journal_title：Clinical and experimental nephrology

authors： Sakai M,Yamamoto K,Mizumura H,Matsumoto T,Tanaka Y,Noda Y,Ishibashi K,Yamamoto T,Sasaki S

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Vascular endothelial cells (VECs) play crucial roles in physiological and pathologic conditions in tissues and organs. Most of these roles are related to VEC plasma membrane proteins. In the kidney, VECs are closely associated with structures and functions; however, plasma membrane proteins in kidney VECs re...

journal_title：Clinical and experimental nephrology

authors： Liu Z,Xu B,Nameta M,Zhang Y,Magdeldin S,Yoshida Y,Yamamoto K,Fujinaka H,Yaoita E,Tasaki M,Nakagawa Y,Saito K,Takahashi K,Yamamoto T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Depending on the etiology and pathophysiology of hematuria, urinary bleeding is classified as glomerular hematuria or nonglomerular hematuria. Nephritis is usually detected by the presence of proteinuria, especially elevated albumin excretion. In this study, we report on the use of the urinary albumin-to-tot...

journal_title：Clinical and experimental nephrology

authors： Ohisa N,Kanemitsu K,Matsuki R,Suzuki H,Miura H,Ohisa Y,Yoshida K,Kaku M,Sato H

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Guidelines for treatment of hypertension are not available for chronic hemodialysis (HD) population, despite the high mortality rate due to cardiovascular disease (CVD). Survival is much better among hypertensive patients than normal to hypotensive patients. Target levels of blood pressure and the class of a...

journal_title：Clinical and experimental nephrology

authors： Iseki K,Tokuyama K,Shiohira Y,Higa A,Hirano H,Toma S,Kohagura K,Ueda S

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:To investigate whether pre-dialysis level of serum creatinine (SCre) could indicate the responsiveness to zinc supplementation of patients on maintenance hemodialysis (MHD). METHODS:We retrospectively reviewed the results of our previous randomized study of 91 patients who had been on MHD and received zinc ...

journal_title：Clinical and experimental nephrology

authors： Okamoto T,Hatakeyama S,Togashi K,Hamaya T,Tanaka Y,Imanishi K,Takashima T,Saitoh F,Suzuki T,Ohyama C

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Aging is well known as one of the major causes of a reduced glomerular filtration rate (GFR). The resistive index (RI) measured by renal Doppler ultrasonography (RDU) is thought to be a good indicator of renal vascular resistance induced by arteriosclerosis. In this study, we investigated whether RI could be...

journal_title：Clinical and experimental nephrology

authors： Kawai T,Kamide K,Onishi M,Hongyo K,Yamamoto-Hanasaki H,Oguro R,Maekawa Y,Yamamoto K,Takeya Y,Sugimoto K,Ohishi M,Rakugi H

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:The Oxford Classification is utilized globally, but has not been fully validated. In this study, we conducted a comparative analysis between the Oxford Classification and Japanese Histologic Classification (JHC) to predict renal outcome in Japanese patients with IgA nephropathy (IgAN). METHODS:A retrospecti...

journal_title：Clinical and experimental nephrology

authors： Kaihan AB,Yasuda Y,Katsuno T,Kato S,Imaizumi T,Ozeki T,Hishida M,Nagata T,Ando M,Tsuboi N,Maruyama S

更新日期：2017-12-01 00:00:00

abstract：:Idiopathic nephrotic syndrome is the most common chronic glomerular disease in children. At least 20 % of children with this syndrome show frequent relapses and/or steroid dependence during or after immunosuppressive therapies, a condition defined as complicated frequently relapsing/steroid-dependent nephrotic syndrom...

journal_title：Clinical and experimental nephrology

authors： Iijima K,Sako M,Nozu K

更新日期：2017-04-01 00:00:00

abstract：:The clinical course of cryoglobulinemic glomerulonephritis (CGGN) is usually slowly progressive, and only a minority of these patients progress to end-stage renal failure. This report describes an atypical case of a patient with CGGN who demonstrated a rapidly progressive and irreversible renal deterioration. After pr...

journal_title：Clinical and experimental nephrology

authors： Tsuboi N,Ichinose M,Kawamura T,Joh K,Utsunomiya Y,Hosoya T

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 (CoQ10). METHODS:Three-week-old heminephrectomized male Sprague-Dawley rats were divided into three groups (10 animals each): diet with normal (0.3%) salt, high (8%) salt, and high salt plus 60...

journal_title：Clinical and experimental nephrology

authors： Ishikawa A,Kawarazaki H,Ando K,Fujita M,Fujita T,Homma Y

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease is a predictor of end-stage renal disease (ESRD) and cardiovascular disease (CVD). Therefore, the medical expenses are higher with the decrease in glomerular filtration rate (GFR). However, few studies have examined the medical expenses according to the baseline GFR. METHODS:We invest...

journal_title：Clinical and experimental nephrology

authors： Iseki K,Iseki C,Kurahashi I,Watanabe T

更新日期：2013-06-01 00:00:00

abstract：:A 69-year-old woman presented with unusual electron microscopic findings. The patient was admitted to ascertain the cause of her persistent proteinuria, and kidney biopsy was performed. While light microscopic findings and immunofluorescence study suggested membranous nephropathy, electron microscopic study showed mic...

journal_title：Clinical and experimental nephrology

authors： Nomura S,Inoue-Kiyohara M,Oosugi K,Ishikawa E,Obe T,Horiki T,Ito M

更新日期：2008-12-01 00:00:00

abstract：:We describe here two sisters with nephronophthisis, which was not detected until the development of endstage renal failure. Twenty- and 15-year-old female siblings were admitted to our hospital for further examination of renal dysfunction. No urinalysis abnormalities had been found in yearly health checks in either pa...

journal_title：Clinical and experimental nephrology

authors： Ashizawa M,Miyazaki M,Furusu A,Abe K,Kanamoto Y,Iwanaga N,Ozono Y,Harada T,Taguchi T,Kohno S

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:The Determinants of the prescribed dialysis dose have not been well studied in a large patient population. Few studies have examined survival rates after adjusting for dose determinants. METHODS:Data were obtained from a cohort of chronic hemodialysis patients for the period January 1991 through December 20...

journal_title：Clinical and experimental nephrology

authors： Iseki K,Tozawa M,Takishita S

更新日期：2003-09-01 00:00:00

abstract：:A 78-year old woman with complicating solitary kidney had nephrotic syndrome. Renal biopsy specimens showed focal segmental glomerulosclerosis (FSGS). First, the patient was treated with angiotensin receptor blocker (ARB) and angiotensin converting enzyme inhibitor (ACEI). Proteinuria decreased from 10 to 6 g/day, but...

journal_title：Clinical and experimental nephrology

authors： Oshiro Y,Umena S,Noda M

更新日期：2009-02-01 00:00:00

abstract：:Lipoprotein glomerulopathy (LPG) is a rare hereditary disease characterized by the accumulation of much thrombi material consisting of lipoproteins at the glomerular capillary lumen. Most patients show nephrotic syndrome; nearly half progress to chronic renal failure. Intensive therapy with lipid-lowering agents repor...

journal_title：Clinical and experimental nephrology

authors： Matsunaga A,Furuyama M,Hashimoto T,Toyoda K,Ogino D,Hayasaka K

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Peritoneal dialysis (PD) exchange procedure is complex. Patients with cognitive impairment (CI) may require assistance. We studied the prevalence of CI among PD patients, its impact on PD-related peritonitis and the outcome of assisted PD. METHODS:Cantonese version of Mini-Mental State examination (CMMSE) w...

journal_title：Clinical and experimental nephrology

authors： Shea YF,Lam MF,Lee MS,Mok MY,Lui SL,Yip TP,Lo WK,Chu LW,Chan TM

更新日期：2016-02-01 00:00:00

abstract：:We present a case of proliferative glomerulonephritis with peculiar IgM deposition associated with sarcoidosis. A 62-year-old woman, who had been diagnosed with sarcoidosis 3 years previously because of abnormalities on chest X-ray radiophotographs and lymph node pathology, was admitted to our hospital for the evaluat...

journal_title：Clinical and experimental nephrology

authors： Kanamori H,Ota M,Takeoka H,Osafune K,Yonezu S,Fukatsu A,Kanatsu K

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:The risk of developing CKD is increased in HIV-infected patients; however, the relationship between renal function decline and lipid abnormalities currently remains unclear in these patients. METHODS:A retrospective cohort study was conducted on 661 HIV-infected patients, whose estimated glomerular filtrati...

journal_title：Clinical and experimental nephrology

authors： Hara M,Yanagisawa N,Ohta A,Momoki K,Tsuchiya K,Nitta K,Ando M

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The number of patients with chronic kidney disease (CKD) in Japan is currently rising. Therefore, measures to control the progression of CKD from a predialysis condition to endstage renal failure are urgently required. We are conducting a clinical trial to investigate the efficacy of an oral carbonaceous ads...

journal_title：Clinical and experimental nephrology

authors： Morita S,Fukuhara S,Akizawa T,Asano Y,Kurokawa K

更新日期：2005-09-01 00:00:00

abstract：:Chronic kidney disease (CKD), as defined by reduced glomerular filtration rate (<60 ml/min/1.73 m(2)) and/or the presence of renal damage for >3 months, is a significant threat for public health in modern societies. Recent epidemiological studies have demonstrated that CKD is a significant risk for cardiovascular even...

journal_title：Clinical and experimental nephrology

authors： Ito S

更新日期：2012-02-01 00:00:00

abstract：:Because of the increasing incidence of cardiac failure and chronic renal failure due to the progressive aging of the population, the extensive application of cardiac interventional techniques, the rising rates of obesity and diabetes mellitus, coexistence of heart failure and renal failure in the same patient are freq...

journal_title：Clinical and experimental nephrology

authors： Longhini C,Molino C,Fabbian F

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:IgG4-related disease has attracted wide attention recently. It is characterized by a high level of serum IgG4 and dense infiltration of IgG4-positive plasma cells into multiple organs, with the kidney being one representative target. Although several sets of diagnostic criteria for autoimmune pancreatitis (A...

journal_title：Clinical and experimental nephrology

authors： Kawano M,Saeki T,Nakashima H,Nishi S,Yamaguchi Y,Hisano S,Yamanaka N,Inoue D,Yamamoto M,Takahashi H,Nomura H,Taguchi T,Umehara H,Makino H,Saito T

更新日期：2011-10-01 00:00:00

abstract：AIM:IgA nephropathy (IgAN) is a very common glomerulonephritis among young adults, but the best therapeutic approach has not been fully elucidated. This study evaluated the effect of two different treatment regimes in IgAN, steroids alone or in combination with azathioprine. METHODS:Among 122 patients with primary IgA...

journal_title：Clinical and experimental nephrology

authors： Stangou M,Ekonomidou D,Giamalis P,Liakou H,Tsiantoulas A,Pantzaki A,Papagianni A,Efstratiadis G,Alexopoulos E,Memmos D

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Peritoneal injury is an important cause of technical failure of long-term peritoneal dialysis (PD). Encapsulating peritoneal sclerosis (EPS) is a severe complication of long-term PD with potentially life threatening consequences. CD147 is a glycoprotein with diverse functions including modulation of extracel...

journal_title：Clinical and experimental nephrology

authors： Seeger H,Latus J,Kitterer D,Alscher MD,Biegger D,Chen J,Edenhofer I,Wüthrich RP,Segerer S

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Microalbuminuria, a marker of vascular damage, is associated with increased risk of progressive renal deterioration, cardiovascular disease and mortality. However, the relationship between antinuclear antibody (ANA) and microalbuminuria in the general population is unknown. Thus, we conducted a cross-section...

journal_title：Clinical and experimental nephrology

authors： Ishikawa M,Konta T,Hao Z,Takasaki S,Abiko H,Takahashi T,Ikeda A,Ichikawa K,Shibata Y,Takeishi Y,Kato T,Kawata S,Kubota I

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:A close correlation has been shown between tubulointerstitial (TI) injury and the outcome of renal dysfunction, and nuclear factor-kappaB (NFkappaB) has been shown to play a key role in proteinuria-induced TI injury. To explore the molecular mechanisms of the proteinuria-induced TI injury further, we have an...

journal_title：Clinical and experimental nephrology

authors： Takase O,Marumo T,Hishikawa K,Fujita T,Quigg RJ,Hayashi M

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The present study was conducted to clarify the clinical risk factors related to the development of encapsulating peritoneal sclerosis (EPS), which is one of the most serious complications in patients undergoing peritoneal dialysis (PD). METHODS:The records of 78 patients with a history of PD treatment, incl...

journal_title：Clinical and experimental nephrology

authors： Yamamoto R,Otsuka Y,Nakayama M,Maruyama Y,Katoh N,Ikeda M,Yamamoto H,Yokoyama K,Kawaguchi Y,Matsushima M

更新日期：2005-06-01 00:00:00