Abstract:
BACKGROUND:To investigate whether pre-dialysis level of serum creatinine (SCre) could indicate the responsiveness to zinc supplementation of patients on maintenance hemodialysis (MHD). METHODS:We retrospectively reviewed the results of our previous randomized study of 91 patients who had been on MHD and received zinc supplementation with either zinc acetate hydrate (ZAH; zinc, 50 mg/day) or polaprezinc (PPZ; zinc, 34 mg/day). A late response to zinc supplementation was defined as a serum zinc level of < 80 μg/dL three months after the study began. Patients were divided into two groups: late response (serum zinc level < 80 μg/dL) and early response (serum zinc level ≥ 80 μg/dL). Factors independently associated with a late response to zinc supplementation were determined using inverse probability of treatment weighting (IPTW) multivariate logistic analysis. RESULTS:Of 91 patients, 86 continued to receive zinc supplementation after three months. The mean pre-dialysis SCre level was 10.0 mg/dL. The number of patients with a late response and response to zinc supplementation was 32 and 54, respectively. There was a significant negative correlation between the pre-dialysis SCre and the Δserum zinc change for 3 months. (r = - 0.284, P = 0.008). IPTW multivariate analysis showed that a pre-dialysis SCre level ≥ 10.0 mg/dL (odds ratio, 3.71; 95% confidence interval; 1.24-11.1, P = 0.022) was an independent factor associated with a late response to zinc supplementation. CONCLUSIONS:Pre-dialysis SCre level was independently associated with responsiveness to zinc supplementation after three months in patients on MHD.
journal_name
Clin Exp Nephroljournal_title
Clinical and experimental nephrologyauthors
Okamoto T,Hatakeyama S,Togashi K,Hamaya T,Tanaka Y,Imanishi K,Takashima T,Saitoh F,Suzuki T,Ohyama Cdoi
10.1007/s10157-020-01911-xsubject
Has Abstractpub_date
2020-10-01 00:00:00pages
955-962issue
10eissn
1342-1751issn
1437-7799pii
10.1007/s10157-020-01911-xjournal_volume
24pub_type
杂志文章abstract:BACKGROUND:The Oxford Classification is utilized globally, but has not been fully validated. In this study, we conducted a comparative analysis between the Oxford Classification and Japanese Histologic Classification (JHC) to predict renal outcome in Japanese patients with IgA nephropathy (IgAN). METHODS:A retrospecti...
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