Profiling of kidney vascular endothelial cell plasma membrane proteins by liquid chromatography-tandem mass spectrometry.

abstract：BACKGROUND:In 2013, eculizumab was approved for treatment of the atypical hemolytic-uremic syndrome (aHUS) in Japan, which was defined as a thrombotic microangiopathy (TMA) excluding Shiga toxin-producing Escherichia coli-HUS and thrombotic thrombocytopenic purpura. Simultaneously, post-marketing surveillance was start...

journal_title：Clinical and experimental nephrology

authors： Ito S,Hidaka Y,Inoue N,Kaname S,Kato H,Matsumoto M,Miyakawa Y,Mizuno M,Okada H,Shimono A,Matsuda T,Maruyama S,Fujimura Y,Nangaku M,Kagami S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 (CoQ10). METHODS:Three-week-old heminephrectomized male Sprague-Dawley rats were divided into three groups (10 animals each): diet with normal (0.3%) salt, high (8%) salt, and high salt plus 60...

journal_title：Clinical and experimental nephrology

authors： Ishikawa A,Kawarazaki H,Ando K,Fujita M,Fujita T,Homma Y

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The present study aimed to clarify the beneficial effect of allopurinol on cardiovascular morbidity and mortality in a cohort of hypertensive nephropathy patients with impaired kidney function. METHODS:One hundred and seventy-eight patients diagnosed with hypertensive nephropathy and presenting with impaire...

journal_title：Clinical and experimental nephrology

authors： Terawaki H,Nakayama M,Miyazawa E,Murata Y,Nakayama K,Matsushima M,Miyazaki M,Sato H,Sato M,Sato T,Taguma Y,Ito S

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Peritoneal injury is an important cause of technical failure of long-term peritoneal dialysis (PD). Encapsulating peritoneal sclerosis (EPS) is a severe complication of long-term PD with potentially life threatening consequences. CD147 is a glycoprotein with diverse functions including modulation of extracel...

journal_title：Clinical and experimental nephrology

authors： Seeger H,Latus J,Kitterer D,Alscher MD,Biegger D,Chen J,Edenhofer I,Wüthrich RP,Segerer S

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Sirt1, a mammalian homolog of silent information regulator 2 (Sir2), is the founding member of class III histone deacetylase (HDAC). METHODS:In this study, we examined whether Sirt1 is involved in the modification of acetylated histone H3, acetylated p53 and Werner syndrome protein (WRN), which is stabilize...

journal_title：Clinical and experimental nephrology

authors： Sakao Y,Kato A,Tsuji T,Yasuda H,Togawa A,Fujigaki Y,Kahyo T,Setou M,Hishida A

更新日期：2011-06-01 00:00:00

abstract：:We describe here two sisters with nephronophthisis, which was not detected until the development of endstage renal failure. Twenty- and 15-year-old female siblings were admitted to our hospital for further examination of renal dysfunction. No urinalysis abnormalities had been found in yearly health checks in either pa...

journal_title：Clinical and experimental nephrology

authors： Ashizawa M,Miyazaki M,Furusu A,Abe K,Kanamoto Y,Iwanaga N,Ozono Y,Harada T,Taguchi T,Kohno S

更新日期：2005-12-01 00:00:00

abstract：:Idiopathic nephrotic syndrome is the most common chronic glomerular disease in children. At least 20 % of children with this syndrome show frequent relapses and/or steroid dependence during or after immunosuppressive therapies, a condition defined as complicated frequently relapsing/steroid-dependent nephrotic syndrom...

journal_title：Clinical and experimental nephrology

authors： Iijima K,Sako M,Nozu K

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Hematuria is the first manifestation of urinary abnormality in immunoglobulin A nephropathy (IgAN). Hematuria has recently been reported as a risk factor for deterioration of renal function; however, its cause remains unknown. METHODS:We analyzed the surface marker of peripheral blood mononuclear cells befo...

journal_title：Clinical and experimental nephrology

authors： Iwatani H,Nagasawa Y,Yamamoto R,Iio K,Mizui M,Horii A,Kitahara T,Inohara H,Kumanogoh A,Imai E,Rakugi H,Isaka Y

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Although congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of pediatric end-stage renal disease (ESRD), little is known about the characteristics exhibited in the infantile period by CAKUT patients who develop ESRD. Further, an efficient screening method for CAKUT diagnos...

journal_title：Clinical and experimental nephrology

authors： Yoshino A,Honda M,Sasaki N,Hataya H,Ishikura K,Sakazume S,Tanaka Y,Nagai T

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:In the tubular cells of patients with polycystic kidney disease (PKD), a reduced intracellular Ca(2+) level accelerates cell proliferation, resulting in cyst formation. Thus, whether calcium channel blockers (CCB) are useful for the treatment of hypertension in patients with PKD is questionable. METHODS:Thi...

journal_title：Clinical and experimental nephrology

authors： Mitobe M,Yoshida T,Sugiura H,Shiohira S,Shimada K,Nitta K,Tsuchiya K

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Renal inulin clearance is the gold standard for glomerular filtration rate (GFR), but is compromised by problems of collecting urine samples in children, especially those <6 years of age or with a bladder dysfunction. Therefore, we should utilize the serum creatinine (Cr)-based estimated GFR (eGFR), measurin...

journal_title：Clinical and experimental nephrology

authors： Nagai T,Uemura O,Ishikura K,Ito S,Hataya H,Gotoh Y,Fujita N,Akioka Y,Kaneko T,Honda M

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Ambulatory blood pressure (ABP) monitoring and carotid-femoral pulse wave velocity (cfPWV) provide important cardiovascular risk information for dialysis patients. This study aims to evaluate the risk factors of cfPWV and the associations between ambulatory blood pressure, especially night-time blood pressur...

journal_title：Clinical and experimental nephrology

authors： Li X,Jiang Q,Wu W,Xu X,Miao L,Jin L,Xue L,Huang T,Di J,Liu J,He X

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Peritoneal dialysis (PD) exchange procedure is complex. Patients with cognitive impairment (CI) may require assistance. We studied the prevalence of CI among PD patients, its impact on PD-related peritonitis and the outcome of assisted PD. METHODS:Cantonese version of Mini-Mental State examination (CMMSE) w...

journal_title：Clinical and experimental nephrology

authors： Shea YF,Lam MF,Lee MS,Mok MY,Lui SL,Yip TP,Lo WK,Chu LW,Chan TM

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor common to both chronic kidney disease and cardiovascular disease. Nicorandil is widely used for the treatment of angina. We investigated the benefits of nicorandil with respect to renal dysfunction in Dahl salt-sensitive hypertensive (DS) rats. METHOD:DS rats were fed a high-sa...

journal_title：Clinical and experimental nephrology

authors： Tashiro Y,Yogo K,Serizawa K,Endo K

更新日期：2015-06-01 00:00:00

abstract：:Distal renal tubular acidosis (dRTA) results from impaired urinary acidification by the renal collecting duct. Acquired dRTA can be secondary to diverse pathological processes, including diabetic, ischemic, fibrosing, or immunological processes; less frequently it presents as a familial disorder with either an autosom...

journal_title：Clinical and experimental nephrology

authors： Shayakul C,Alper SL

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor (SURI), increases urinary uric acid excretion. The aim of this study is to examine the pharmacokinetics, pharmacodynamics, and safety of dotinurad according to the type of hyperuricemia, with or without concomitant use of xanthine oxidase inhibitor, i...

journal_title：Clinical and experimental nephrology

authors： Okui D,Sasaki T,Fushimi M,Ohashi T

更新日期：2020-03-01 00:00:00

abstract：:C1q nephropathy, first proposed by Jennette and Hipp [Am J Clin Pathol 83:415-420, 1985; Am J Kidney Dis 6:103-110, 1985], was described as a distinct glomerular disease entity characterized by extensive mesangial deposition of C1q, with associated mesangial immune complexes, and the absence of any clinical and labora...

journal_title：Clinical and experimental nephrology

authors： Mii A,Shimizu A,Masuda Y,Fujita E,Aki K,Ishizaki M,Sato S,Griesemer A,Fukuda Y

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:The etiology of hemodialysis (HD)-induced hypotension and hypertension remains speculative. There is mounting evidence that endothelin-1 (ET-1) may play a vital role in these hemodynamic changes. We examined the possible role of intradialytic changes of ET-1 in the pathogenesis of hypotension and rebound hyp...

journal_title：Clinical and experimental nephrology

authors： El-Shafey EM,El-Nagar GF,Selim MF,El-Sorogy HA,Sabry AA

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Thallium-201 washout rate of stress myocardial perfusion imaging (MPI) has been reported to correlate with coronary flow reserve which is a parameter of myocardial microcirculation. However, the evidence for its use in diabetic kidney disease (DKD) has been lacking, and the association between thallium-201 w...

journal_title：Clinical and experimental nephrology

authors： Hayashi T,Joki N,Tanaka Y,Iwasaki M,Kubo S,Matsukane A,Takahashi Y,Imamura Y,Hirahata K,Hase H

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The renoprotection achieved by angiotensin II blockade in the treatment of diabetic nephropathy is well established in both the clinical and the experimental settings. In contrast, the therapeutic efficacy of calcium channel blockers (CCBs) in the treatment of diabetic nephropathy still remains controversial...

journal_title：Clinical and experimental nephrology

authors： Moriyama T,Oka K,Ueda H,Imai E

更新日期：2004-09-01 00:00:00

abstract：:A 69-year-old Caucasian man was admitted to our hospital because of myocardial infarction. A central venous catheter (CVC) for infusive therapy was inserted. After two weeks he developed fever, purpura, and knee arthralgia. Hemoculture yielded methicillin-sensitive Staphylococcus aureus. Subsequently, oliguric renal f...

journal_title：Clinical and experimental nephrology

authors： Uggeri S,Fabbian F,Catizone L

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:We previously reported a significant increase in plasma TGF-beta1 in patients with chronic renal failure (CRF). Progression of CRF may be caused by persistent renal production of TGF-beta1. In CRF rat models, an oral carbonic absorbent (AST-120) reduces the expression of the TGF-beta1 gene in the kidney, and...

journal_title：Clinical and experimental nephrology

authors： Iida S,Kohno K,Yoshimura J,Ueda S,Usui M,Miyazaki H,Nishida H,Tamaki K,Okuda S

更新日期：2006-12-01 00:00:00

abstract：:A 77-year-old man with a history of hypertension and hyperuricemia was admitted to our hospital complaining of limb weakness, persistent constipation, and worsening hypertension. He had been taking a Chinese herbal remedy for allergic rhinitis for the past 10 years, together with an angiotensin-converting enzyme inhib...

journal_title：Clinical and experimental nephrology

authors： Iida R,Otsuka Y,Matsumoto K,Kuriyama S,Hosoya T

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Although it has been repeatedly shown that the oral carbonaceous absorbent AST-120 ameliorates the progression of chronic renal failure, the mechanisms remain unknown. METHODS:Male Sprague-Dawley rats (6 weeks old), weighing 180-210 g, were 4/5 nephrectomized, and were divided into two groups: one given AST...

journal_title：Clinical and experimental nephrology

authors： Horike K,Usami T,Kamiya Y,Kamiya T,Yoshida A,Itoh S,Yamato H,Ise M,Kimura G

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:The appropriate blood pressure target to prevent end-stage renal disease (ESRD) is controversial. METHODS:We examined the association between systolic blood pressure (SBP) changes and ESRD incidence in 69,575 participants from the Okinawa general population aged ≥ 20 years who underwent health check-ups in ...

journal_title：Clinical and experimental nephrology

authors： Usui T,Iseki C,Iseki K,Kawakami K,Nangaku M

更新日期：2019-11-01 00:00:00

abstract：:Microscopic polyangiitis is a necrotizing angiitis involving capillaries, venules, and arterioles. The vascular beds of various organs may be involved, causing varying presentations. To our knowledge, this is the first case of anti-myeloperoxidase (anti-MPO) antibody small-vessel vasculitis causing prostatic vasculiti...

journal_title：Clinical and experimental nephrology

authors： Lamarche JA,Peguero AM,Rosario JO,Patel A,Courville C

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Analyses of selected cases suggest that immunosuppressive treatment could reduce proteinuria and delay the progression of immunoglobulin A nephropathy (IgAN). The aim of this study was to examine the long-term effectiveness of this therapy on the clinical course of IgAN. We also examined the relationship bet...

journal_title：Clinical and experimental nephrology

authors： Oshima S,Kawamura O

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis frequently induces crescentic glomerulonephritis. However, a few cases have so far been reported to have only tubulointerstitial (TI) nephritis without any apparent glomerular lesions. We recently treated three similar cases...

journal_title：Clinical and experimental nephrology

authors： Nakabayashi K,Sumiishi A,Sano K,Fujioka Y,Yamada A,Karube M,Koji H,Arimura Y,Nagasawa T

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Maxacalcitol (22-oxacalcitriol; OCT) is a novel vitamin D analogue. In previous clinical studies, OCT was administered three times a week to hemodialysis patients with refractory secondary hyperparathyroidism (2HPT), in whom it acted by inhibiting parathyroid hormone secretion, as well as causing mildly elev...

journal_title：Clinical and experimental nephrology

authors： Murakami K,Miyachi H,Watanabe A,Kawamura N,Fujii M,Koide S,Murase M,Kushimoto H,Hasegawa M,Tomita M,Hiki Y,Sugiyama S

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:No consensus exists on the amount of bed rest required after renal biopsy. Moreover, forced prolonged bed rest can be uncomfortable in patients undergoing renal biopsy. OBJECTIVE:To evaluate whether the length of strict bed rest affects the incidence of pain and other complications after renal biopsy. STUDY...

journal_title：Clinical and experimental nephrology

authors： Ishikawa E,Nomura S,Obe T,Katayama K,Oosugi K,Murata T,Tanoue A,Fujimoto M,Matsuo H,Ito M

更新日期：2009-12-01 00:00:00