Thallium-201 washout rate of stress myocardial perfusion imaging as a predictor of mortality in diabetic kidney disease patients initiating hemodialysis: an observational, follow-up study.

abstract：BACKGROUND:Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis frequently induces crescentic glomerulonephritis. However, a few cases have so far been reported to have only tubulointerstitial (TI) nephritis without any apparent glomerular lesions. We recently treated three similar cases...

journal_title：Clinical and experimental nephrology

authors： Nakabayashi K,Sumiishi A,Sano K,Fujioka Y,Yamada A,Karube M,Koji H,Arimura Y,Nagasawa T

更新日期：2009-12-01 00:00:00

abstract：:A 77-year-old Japanese female developed Churg-Strauss syndrome (CSS), showing fever and numbness in bilateral hands. She was being treated for bronchial asthma with combination inhalant of corticosteroid with beta(2)-agonist, and an oral leukotriene receptor antagonist (LTRA), montelukast, for 15 months. She presented...

journal_title：Clinical and experimental nephrology

authors： Kanda T,Tanio H,Wu C,Nishihara H,Nogaki F,Ono T

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that GFR estimated from serum creatinine (eGFRcr) is higher in smokers although the implications remain unclear. We aimed to clarify the associations of smoking with eGFRcys (GFR estimated from serum cystatin C) and eGFRcr, cys (the surmised most precise GFR estimate based on seru...

journal_title：Clinical and experimental nephrology

authors： Yamada Y,Noborisaka Y,Ishizaki M,Yamazaki M,Honda R,Yokoyama H,Kakuma T

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor, exerts a serum uric acid-lowering effect by selectively inhibiting urate transporter 1 (URAT1) in patients with hyperuricemia. It is generally known that the progression of renal dysfunction is associated with a reduction in the serum uric acid-lower...

journal_title：Clinical and experimental nephrology

authors： Fukase H,Okui D,Sasaki T,Fushimi M,Ohashi T,Hosoya T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Acute renal infarction (ARI) is a rare disease with atrial fibrillation being its main cause. The possible laterality of ARI is controversial. This study aimed to evaluate the association between anatomical features of the renal arteries and ARI. METHODS:This was a single-center cross-sectional study that e...

journal_title：Clinical and experimental nephrology

authors： Kagaya S,Ojima Y,Aoki S,Sato H,Nagasawa T

更新日期：2018-10-01 00:00:00

abstract：:A 33-year-old woman was transferred to our hospital with a 5-month history of taking Chinese herbal medicine containing aristolochic acid. She presented with metabolic acidosis, severe anemia, hypophosphatemia and uric aciduria, and generalized aminoaciduria and glycosuria, features which were consistent with the clin...

journal_title：Clinical and experimental nephrology

authors： Kazama I,Matsubara M,Michimata M,Suzuki M,Hatano R,Sato H,Ito S

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Aging is well known as one of the major causes of a reduced glomerular filtration rate (GFR). The resistive index (RI) measured by renal Doppler ultrasonography (RDU) is thought to be a good indicator of renal vascular resistance induced by arteriosclerosis. In this study, we investigated whether RI could be...

journal_title：Clinical and experimental nephrology

authors： Kawai T,Kamide K,Onishi M,Hongyo K,Yamamoto-Hanasaki H,Oguro R,Maekawa Y,Yamamoto K,Takeya Y,Sugimoto K,Ohishi M,Rakugi H

更新日期：2012-10-01 00:00:00

abstract：:Dyslipidemia is an established risk factor for atherosclerotic disease, such as stroke and ischemic heart disease, and is often detected in patients with chronic kidney disease (CKD). The role of dyslipidemia in CKD progression, however, is not well understood. CKD patients are heterogeneous and may include those who ...

journal_title：Clinical and experimental nephrology

authors： Iseki K

更新日期：2014-04-01 00:00:00

abstract：:Increasing attention has been paid to the relationship of autoantibodies to ribosomal P proteins (anti-P) with lupus nephritis. Several mechanisms of involvement of anti-P in lupus nephritis have been proposed, including cross-reactivity with anti-dsDNA and anti-endothelial cell antibodies (AECA). In addition, it is a...

journal_title：Clinical and experimental nephrology

authors： Hirohata S

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:The number of patients with chronic kidney disease (CKD) in Japan is currently rising. Therefore, measures to control the progression of CKD from a predialysis condition to endstage renal failure are urgently required. We are conducting a clinical trial to investigate the efficacy of an oral carbonaceous ads...

journal_title：Clinical and experimental nephrology

authors： Morita S,Fukuhara S,Akizawa T,Asano Y,Kurokawa K

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:In Japan, systematic evaluation of the histologic parameters of anti-neutrophil cytoplasmic autoantibodies (ANCA)-related vasculitis has been performed according to the Japanese classification by Shigematsu et al. However, this classification is quite different from that of the European Vasculitis Study Grou...

journal_title：Clinical and experimental nephrology

authors： Joh K,Muso E,Shigematsu H,Nose M,Nagata M,Arimura Y,Yumura W,Wada T,Nitta K,Makino H,Taguma Y,Kaneoka H,Suzuki Y,Kobayashi M,Koyama A,Usui J,Hashimoto H,Ozaki S,Tomino Y,Yamagata K

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Accurate glomerular filtration rate (GFR) evaluation is significant for drug dosing of carboplatin, anticancer drug excreted mainly from kidney. Serum cystatin-C (sCys-C) is a GFR marker with little affected by body muscle mass volume. And GFR equations based on serum creatinine (eGFRcreat) and sCys-C (eGFRc...

journal_title：Clinical and experimental nephrology

authors： Shibata K,Yasuda Y,Kobayashi R,Ando Y,Shimokata T,Kamiya H,Hayashi M,Maruyama S,Matsuo S,Nakao M,Tsuchiya T,Teramachi H

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Genetic susceptibility to atypical hemolytic uremic syndrome (aHUS) may lie within genes regulating or activating the alternate complement and related pathways converging on endothelial cell activation. METHODS:We tested 32 Indian patients of aHUS negative for antibodies to complement factor H for genetic v...

journal_title：Clinical and experimental nephrology

authors： Thergaonkar RW,Narang A,Gurjar BS,Tiwari P,Puraswani M,Saini H,Sinha A,Varma B,Mukerji M,Hari P,Bagga A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Vascular calcification is common in chronic kidney disease (CKD) patients, while erythropoietin (EPO) is widely used in the treatment of renal anemia in CKD patients, whether there is a link between the two is still not clear. METHODS:The primary rat vascular smooth muscle cells (VSMCs) and CKD rats were tr...

journal_title：Clinical and experimental nephrology

authors： He J,Zhong X,Zhao L,Gan H

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:In the tubular cells of patients with polycystic kidney disease (PKD), a reduced intracellular Ca(2+) level accelerates cell proliferation, resulting in cyst formation. Thus, whether calcium channel blockers (CCB) are useful for the treatment of hypertension in patients with PKD is questionable. METHODS:Thi...

journal_title：Clinical and experimental nephrology

authors： Mitobe M,Yoshida T,Sugiura H,Shiohira S,Shimada K,Nitta K,Tsuchiya K

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Hematuria is the first manifestation of urinary abnormality in immunoglobulin A nephropathy (IgAN). Hematuria has recently been reported as a risk factor for deterioration of renal function; however, its cause remains unknown. METHODS:We analyzed the surface marker of peripheral blood mononuclear cells befo...

journal_title：Clinical and experimental nephrology

authors： Iwatani H,Nagasawa Y,Yamamoto R,Iio K,Mizui M,Horii A,Kitahara T,Inohara H,Kumanogoh A,Imai E,Rakugi H,Isaka Y

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD), one of the most common hereditary kidney diseases, causes gradual growth of cysts in the kidneys, leading to renal failure. Owing to the advanced technology of next-generation sequencing (NGS), genetic analyses of the causative genes PKD1 and PKD2 have be...

journal_title：Clinical and experimental nephrology

authors： Mochizuki T,Teraoka A,Akagawa H,Makabe S,Akihisa T,Sato M,Kataoka H,Mitobe M,Furukawa T,Tsuchiya K,Nitta K

更新日期：2019-08-01 00:00:00

abstract：:C1q nephropathy, first proposed by Jennette and Hipp [Am J Clin Pathol 83:415-420, 1985; Am J Kidney Dis 6:103-110, 1985], was described as a distinct glomerular disease entity characterized by extensive mesangial deposition of C1q, with associated mesangial immune complexes, and the absence of any clinical and labora...

journal_title：Clinical and experimental nephrology

authors： Mii A,Shimizu A,Masuda Y,Fujita E,Aki K,Ishizaki M,Sato S,Griesemer A,Fukuda Y

更新日期：2009-08-01 00:00:00

abstract：:We report a 58-year-old Japanese man with primary systemic AL amyloidosis who achieved disappearance of proteinuria including Bence-Jones protein (lambda-type) after two courses of VAD therapy (vincristine, doxorubicin, and dexamethasone) and subsequent high-dose melphalan, followed by autologous peripheral blood stem...

journal_title：Clinical and experimental nephrology

authors： Yamazaki O,Ubara Y,Suwabe T,Nakanishi S,Hoshino J,Sawa N,Hayami N,Yamanouchi M,Takemoto F,Kenmei T,Masuoka K,Oohashi K

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:It has been recently reported that peroxisome proliferator-activated receptors (PPARs)gamma exist in various tissues and that they exibit anti-inflammatory effects. METHODS:We investigated the effects of PPARgamma activators on the development of crescentic glomerulonephritis. Crescentic glomerulonephritis ...

journal_title：Clinical and experimental nephrology

authors： Haraguchi K,Shimura H,Onaya T

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:A close correlation has been shown between tubulointerstitial (TI) injury and the outcome of renal dysfunction, and nuclear factor-kappaB (NFkappaB) has been shown to play a key role in proteinuria-induced TI injury. To explore the molecular mechanisms of the proteinuria-induced TI injury further, we have an...

journal_title：Clinical and experimental nephrology

authors： Takase O,Marumo T,Hishikawa K,Fujita T,Quigg RJ,Hayashi M

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Edaravone, a drug for treating acute ischemic stroke, has been reported to provoke acute renal disorders. In the previous study, the author evaluated the role of edaravone in the development of renal disorders in 207 patients reported as having developed them in the post-marketing survey of the drug. The ove...

journal_title：Clinical and experimental nephrology

authors： Hishida A

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:The post-marketing surveillance of edaravone has reported serious adverse reactions, including renal and hepatic disorders. Renal disorders were the most frequently reported serious/important adverse reactions, which led to the evaluation of their causation by edaravone, their severity, and the recovery of r...

journal_title：Clinical and experimental nephrology

authors： Hishida A

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that selectively inhibits the reabsorption of uric acid in renal tubules and promotes the excretion of uric acid into urine. In this study, the effects of age and gender on the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotin...

journal_title：Clinical and experimental nephrology

authors： Nakatani H,Fushimi M,Sasaki T,Okui D,Ohashi T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Although recovery of renal function after an episode of acute kidney injury (AKI) is an important clinical measure of morbidity, predictors of withdrawal from renal replacement therapy (RRT) among AKI patients remain unclear. METHODS:In this single-center retrospective cohort study, we examined the clinical...

journal_title：Clinical and experimental nephrology

authors： Ihara K,Ishigami J,Inoshita S

更新日期：2019-06-01 00:00:00

abstract：:The clinical course of cryoglobulinemic glomerulonephritis (CGGN) is usually slowly progressive, and only a minority of these patients progress to end-stage renal failure. This report describes an atypical case of a patient with CGGN who demonstrated a rapidly progressive and irreversible renal deterioration. After pr...

journal_title：Clinical and experimental nephrology

authors： Tsuboi N,Ichinose M,Kawamura T,Joh K,Utsunomiya Y,Hosoya T

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Little is known concerning the risk of hospitalization and the risk of death before receiving dialysis by the stage of chronic kidney disease (CKD) in Japan. METHODS:The subjects comprised a total of 13,911 Japanese men (mean age 49.2 ± 9.9 years). Based on the results of a health checkup performed in 2006,...

journal_title：Clinical and experimental nephrology

authors： Nishikawa K,Takahashi K,Yamada R,Kinaga T,Masato M,Yamamoto M

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Proteinuria caused by glomerular disease is characterized by podocyte injury. Vasopressin V2 receptor antagonists are effective in reducing albuminuria, although their actions on glomerular podocytes have not been explored. The objective of this study was to evaluate the effects of tolvaptan, a selective ora...

journal_title：Clinical and experimental nephrology

authors： Okada T,Sakaguchi T,Hatamura I,Saji F,Negi S,Otani H,Muragaki Y,Kawachi H,Shigematsu T

更新日期：2009-10-01 00:00:00

abstract：:A 34-year-old man who had been on dialysis for about 6 years, and had acquired renal cystic disease, received a renal transplantation. However, in spite of the success of the transplantation, one area without cyst regression was observed in the original kidney. Therefore, carcinoma was suspected and nephrectomy was pe...

journal_title：Clinical and experimental nephrology

authors： Ishikawa I,Saito A,Chikazawa Y,Asaka M,Tomosugi N,Yuri T,Suzuki K,Ueda Y,Ozaki M

更新日期：2003-03-01 00:00:00

abstract：:A 57-year-old woman presented with fever and cellulitis of the right leg. Urinalysis and kidney function were normal on admission. Cellulitis remitted but fever persisted for six weeks. X-ray imaging, cultures, serological assays for viruses and autoimmunity did not reveal the cause of fever. Unexpectedly anti-Scl 70 ...

journal_title：Clinical and experimental nephrology

authors： Vega Stieb J,Goecke Saavedra H,Méndez Olivieri G

更新日期：2008-10-01 00:00:00