Abstract:
:A 77-year-old Japanese female developed Churg-Strauss syndrome (CSS), showing fever and numbness in bilateral hands. She was being treated for bronchial asthma with combination inhalant of corticosteroid with beta(2)-agonist, and an oral leukotriene receptor antagonist (LTRA), montelukast, for 15 months. She presented fever up to 38°C with microscopic hematuria and proteinuria, serum creatinine level of 0.7 mg/dl, and C-reactive protein of 11 mg/dl. After referral to our hospital, eosinophilia and high myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA) level were observed together with hematuria and proteinuria; renal biopsy examination was performed to clarify the disorder. Renal biopsy specimens showed necrotizing crescent formation, severe granulomatous angiitis in an interlobular artery, and interstitial eosinophilic infiltration. It was noted that nearly intact glomeruli were infiltrated with eosinophils. After treatment with oral prednisolone at initial dose of 40 mg (1 mg/kg body weight), urinary findings rapidly became normal with mild elevation of serum creatinine to 1.5 mg/dl and trace level of serum C-reactive protein in 1 month. Because she was previously treated with montelukast without oral corticosteroid, linkage between CSS and LTRA was highly suspected.
journal_name
Clin Exp Nephroljournal_title
Clinical and experimental nephrologyauthors
Kanda T,Tanio H,Wu C,Nishihara H,Nogaki F,Ono Tdoi
10.1007/s10157-010-0313-0subject
Has Abstractpub_date
2010-12-01 00:00:00pages
602-7issue
6eissn
1342-1751issn
1437-7799journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Renin-angiotensin system blockers (RASBs) reduce end-stage kidney disease and cardiovascular event (CVE) development in chronic kidney disease. However, whether RASBs improve long-term prognosis in kidney transplant (KT) recipients remain unknown. METHOD:We investigated 900 kidney transplant patients in a m...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10157-019-01827-1
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:The suitable methods evaluating glomerular filtration rate (GFR) have not been established in patients undergoing radical nephrectomy (RN) or radical nephroureterectomy (RNU) due to urological malignancies in Japan as well as worldwide. METHODS:We examined the relationship between creatinine clearance-based...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-017-1509-3
更新日期:2018-10-01 00:00:00
abstract::Ischemia-reperfusion injury is a main cause of acute kidney injury. Tubular necrosis and interstitial inflammatory cell infiltration are characteristic pathologic changes of acute kidney injury. The main necrotic area should be repaired with new tubular epithelial cells after the injury. On the other hand, some parts ...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-008-0119-5
更新日期:2009-02-01 00:00:00
abstract::Increasing attention has been paid to the relationship of autoantibodies to ribosomal P proteins (anti-P) with lupus nephritis. Several mechanisms of involvement of anti-P in lupus nephritis have been proposed, including cross-reactivity with anti-dsDNA and anti-endothelial cell antibodies (AECA). In addition, it is a...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-011-0462-9
更新日期:2011-08-01 00:00:00
abstract::Acute kidney injury (AKI) is a threatening medical condition associated with poor outcomes at different settings. The development of standardized diagnostic criteria and new biomarkers addressed significant clinical impacts of AKI and the need for an early AKI detection, respectively. There have been some breakthrough...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-020-01920-w
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:In 2013, eculizumab was approved for treatment of the atypical hemolytic-uremic syndrome (aHUS) in Japan, which was defined as a thrombotic microangiopathy (TMA) excluding Shiga toxin-producing Escherichia coli-HUS and thrombotic thrombocytopenic purpura. Simultaneously, post-marketing surveillance was start...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-018-1610-2
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Tolvaptan slowed the rates of total kidney volume (TKV) growth and renal function decline over a 3-year period in patients with autosomal dominant polycystic kidney disease (ADPKD) enrolled in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes (TE...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-020-02009-0
更新日期:2021-01-20 00:00:00
abstract:BACKGROUND:The herbicide paraquat (1, 1'-dimethyl-4, 4'-bipyridylium dichloride; PQ) is a poison well-known to cause delayed mortality due to acute kidney injuries (AKI). This study examines the changes in serum amino acids (AAs) metabolite profiles as surrogate markers of renal cell metabolism and function after paraq...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-019-01702-z
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that GFR estimated from serum creatinine (eGFRcr) is higher in smokers although the implications remain unclear. We aimed to clarify the associations of smoking with eGFRcys (GFR estimated from serum cystatin C) and eGFRcr, cys (the surmised most precise GFR estimate based on seru...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-014-1058-y
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Although it has been repeatedly shown that the oral carbonaceous absorbent AST-120 ameliorates the progression of chronic renal failure, the mechanisms remain unknown. METHODS:Male Sprague-Dawley rats (6 weeks old), weighing 180-210 g, were 4/5 nephrectomized, and were divided into two groups: one given AST...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-003-0222-6
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Children with nephrotic syndrome (NS) have hyperlipidemia, which may lead to endothelial dysfunction. This study evaluated endothelial function and structural atherosclerosis in NS children with disease duration more than 2 years, by assessment of brachial artery flow-mediated dilatation (FMD) and carotid in...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-014-0958-1
更新日期:2015-02-01 00:00:00
abstract::Heavy chain deposition disease (HCDD) is one of three entities of monoclonal immunoglobulin deposition disease, characterized histopathologically by the presence of nodular glomerulosclerosis and glomerular and tubular deposition of monoclonal heavy chains without associated light chains. Although HCDD is an extremely...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-013-0812-x
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Both myeloperoxidase-associated antineutrophil cytoplasmic antibody (MPO-ANCA) and antiglomerular basement membrane antibody (anti-GBM Ab) positivity have been demonstrated in patients with rapidly progressive glomerulonephritis (RPGN), either with or without pulmonary hemorrhage; however, the implications o...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-010-0390-0
更新日期:2011-04-01 00:00:00
abstract::The manifestation of diabetic nephropathy may be a consequence of the actions of certain cytokines and growth factors. Prominent among them is transforming growth factor-β (TGF-β), which promotes renal cell hypertrophy and stimulates extracellular matrix accumulation, the two hallmarks of diabetic renal disease. In ex...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s101570200021
更新日期:2002-09-01 00:00:00
abstract::A Japanese boy aged 14 years presented with gross hematuria associated with mild proteinuria and was diagnosed as having nutcracker syndrome. Magnetic resonance angiography (MRA) revealed significant compression of the left renal vein between the aorta and the superior mesenteric artery with collaterals. A percutaneou...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-003-0267-6
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Equations for the creatinine-based estimated glomerular filtration rate (eGFR) were recently established for Japanese adults (>18 years old) and children (2-11 years old), respectively, but it is unclear whether eGFR can be as useful as 24-h creatinine clearance (CCr) for assessing renal function in patients...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-014-0976-z
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Mizoribine (MZR) has been developed as an immunosuppressive agent, but has a less potent immunosuppressive effect up to 3 mg/kg/day MZR. Therefore, we investigated whether high-dose MZR, at 6 mg/kg/day, would be effective and safe for kidney transplant patients in conjunction with cyclosporine (CsA), basilix...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-012-0669-4
更新日期:2013-02-01 00:00:00
abstract::IgA nephropathy (IgAN) associated with leukemia and lymphoma has not, to our knowledge, been reported in children. Two children suffering from these diseases are described here. One patient developed IgAN at the end of 5 years' chemotherapy for acute lymphocytic leukemia. The other had microscopic hematuria 3 years be...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-007-0009-2
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct. Multiple phosphorylation sites are present at the C-terminal of AQP2 including S256 (serine at 256 residue), S261, S264 and S/T269, which are regulated by vasopressin (VP) to modulate AQP2 traffi...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-020-01899-4
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Stromal cell-derived factor-1α (SDF-1α) is an inflammatory chemokine that plays a critical role in cardiovascular disease. Although persistent inflammation causes renal dysfunction, it remains unclear whether SDF-1α is related to progression of chronic kidney disease. This study examined whether high levels ...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-019-01722-9
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Hypertriglyceridemia (hTG) is a risk factor for progression of chronic kidney disease (CKD); however, it remains unknown whether the adipocytokine complement component 3 (C3) is involved in the association between hTG and CKD. METHODS:The study included 138 patients (54 % male) with non-nephrotic (serum alb...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-013-0825-5
更新日期:2014-06-01 00:00:00
abstract::We herein report two cases of patients with chronic kidney disease who developed hypertensive encephalopathy, which occurred after a sudden discontinuance of antihypertensive agents. Both patients underwent care at our hospital after experiencing neurological abnormalities. In both patients, magnetic resonance imaging...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-009-0252-9
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Hematuria is the first manifestation of urinary abnormality in immunoglobulin A nephropathy (IgAN). Hematuria has recently been reported as a risk factor for deterioration of renal function; however, its cause remains unknown. METHODS:We analyzed the surface marker of peripheral blood mononuclear cells befo...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-014-0968-z
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Adenosine monophosphate (AMP)-activated protein kinase (AMPK), as a sensor of cellular energy status, has been known to play an important role in the pathophysiology of diabetes and its complications. As AMPK is also expressed in podocytes, it is possible that podocyte AMPK would be an important contributing...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-012-0649-8
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease is a predictor of end-stage renal disease (ESRD) and cardiovascular disease (CVD). Therefore, the medical expenses are higher with the decrease in glomerular filtration rate (GFR). However, few studies have examined the medical expenses according to the baseline GFR. METHODS:We invest...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-012-0718-z
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis frequently induces crescentic glomerulonephritis. However, a few cases have so far been reported to have only tubulointerstitial (TI) nephritis without any apparent glomerular lesions. We recently treated three similar cases...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-009-0200-8
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Several comorbidity scoring systems have been developed and validated, mostly in western hemodialysis patients with a high risk of cardiovascular disease. The performance of comorbidity scoring, however, depends on the patient population. In this study, we determine the optimal comorbidity scoring system for...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-017-1418-5
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Proteinuria caused by glomerular disease is characterized by podocyte injury. Vasopressin V2 receptor antagonists are effective in reducing albuminuria, although their actions on glomerular podocytes have not been explored. The objective of this study was to evaluate the effects of tolvaptan, a selective ora...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-009-0196-0
更新日期:2009-10-01 00:00:00
abstract::C1q nephropathy, first proposed by Jennette and Hipp [Am J Clin Pathol 83:415-420, 1985; Am J Kidney Dis 6:103-110, 1985], was described as a distinct glomerular disease entity characterized by extensive mesangial deposition of C1q, with associated mesangial immune complexes, and the absence of any clinical and labora...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-009-0159-5
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Although recovery of renal function after an episode of acute kidney injury (AKI) is an important clinical measure of morbidity, predictors of withdrawal from renal replacement therapy (RRT) among AKI patients remain unclear. METHODS:In this single-center retrospective cohort study, we examined the clinical...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-019-01711-y
更新日期:2019-06-01 00:00:00