The choice of comorbidity scoring system in Chinese peritoneal dialysis patients.

abstract：BACKGROUND:In Japan, systematic evaluation of the histologic parameters of anti-neutrophil cytoplasmic autoantibodies (ANCA)-related vasculitis has been performed according to the Japanese classification by Shigematsu et al. However, this classification is quite different from that of the European Vasculitis Study Grou...

journal_title：Clinical and experimental nephrology

authors： Joh K,Muso E,Shigematsu H,Nose M,Nagata M,Arimura Y,Yumura W,Wada T,Nitta K,Makino H,Taguma Y,Kaneoka H,Suzuki Y,Kobayashi M,Koyama A,Usui J,Hashimoto H,Ozaki S,Tomino Y,Yamagata K

更新日期：2008-08-01 00:00:00

abstract：:A 78-year old woman with complicating solitary kidney had nephrotic syndrome. Renal biopsy specimens showed focal segmental glomerulosclerosis (FSGS). First, the patient was treated with angiotensin receptor blocker (ARB) and angiotensin converting enzyme inhibitor (ACEI). Proteinuria decreased from 10 to 6 g/day, but...

journal_title：Clinical and experimental nephrology

authors： Oshiro Y,Umena S,Noda M

更新日期：2009-02-01 00:00:00

abstract：:Distal renal tubular acidosis (dRTA) results from impaired urinary acidification by the renal collecting duct. Acquired dRTA can be secondary to diverse pathological processes, including diabetic, ischemic, fibrosing, or immunological processes; less frequently it presents as a familial disorder with either an autosom...

journal_title：Clinical and experimental nephrology

authors： Shayakul C,Alper SL

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor common to both chronic kidney disease and cardiovascular disease. Nicorandil is widely used for the treatment of angina. We investigated the benefits of nicorandil with respect to renal dysfunction in Dahl salt-sensitive hypertensive (DS) rats. METHOD:DS rats were fed a high-sa...

journal_title：Clinical and experimental nephrology

authors： Tashiro Y,Yogo K,Serizawa K,Endo K

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Sirt1, a mammalian homolog of silent information regulator 2 (Sir2), is the founding member of class III histone deacetylase (HDAC). METHODS:In this study, we examined whether Sirt1 is involved in the modification of acetylated histone H3, acetylated p53 and Werner syndrome protein (WRN), which is stabilize...

journal_title：Clinical and experimental nephrology

authors： Sakao Y,Kato A,Tsuji T,Yasuda H,Togawa A,Fujigaki Y,Kahyo T,Setou M,Hishida A

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:The Stewart model for analyzing acid-base disturbances emphasizes serum albumin levels, which are ignored in the traditional Boston model. We compared data derived using the Stewart model to those using the Boston model in patients with nephrotic syndrome. METHODS:Twenty-nine patients with nephrotic syndrom...

journal_title：Clinical and experimental nephrology

authors： Kasagi T,Imai H,Miura N,Suzuki K,Yoshino M,Nobata H,Nagai T,Banno S

更新日期：2017-10-01 00:00:00

abstract：:We describe here two sisters with nephronophthisis, which was not detected until the development of endstage renal failure. Twenty- and 15-year-old female siblings were admitted to our hospital for further examination of renal dysfunction. No urinalysis abnormalities had been found in yearly health checks in either pa...

journal_title：Clinical and experimental nephrology

authors： Ashizawa M,Miyazaki M,Furusu A,Abe K,Kanamoto Y,Iwanaga N,Ozono Y,Harada T,Taguchi T,Kohno S

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:The appropriate blood pressure target to prevent end-stage renal disease (ESRD) is controversial. METHODS:We examined the association between systolic blood pressure (SBP) changes and ESRD incidence in 69,575 participants from the Okinawa general population aged ≥ 20 years who underwent health check-ups in ...

journal_title：Clinical and experimental nephrology

authors： Usui T,Iseki C,Iseki K,Kawakami K,Nangaku M

更新日期：2019-11-01 00:00:00

abstract：:We report a case of acute kidney injury (AKI) caused by a novel direct renin inhibitor, aliskiren. A 43-year-old Japanese man with dilated cardiomyopathy on cardiac resynchronization therapy with defibrillator and chronic kidney disease (CKD) was started on aliskiren in addition to enalapril, carvedilol, furosemide, a...

journal_title：Clinical and experimental nephrology

authors： Yamauchi J,Shibagaki Y,Uehara K,Yasuda T,Kimura K

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Vascular calcification is common in chronic kidney disease (CKD) patients, while erythropoietin (EPO) is widely used in the treatment of renal anemia in CKD patients, whether there is a link between the two is still not clear. METHODS:The primary rat vascular smooth muscle cells (VSMCs) and CKD rats were tr...

journal_title：Clinical and experimental nephrology

authors： He J,Zhong X,Zhao L,Gan H

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:The number of elderly dialysis patients in Japan is dramatically increasing. Receiving therapy with better satisfaction through home care is one of the important factors in their daily lives. Thus, the quality of life of elderly patients on hemodialysis (HD) or peritoneal dialysis (PD) was evaluated. METHOD...

journal_title：Clinical and experimental nephrology

authors： Saka Y,Naruse T,Tawada N,Tokomoto M,Noda Y,Taniguchi Y,Nagahara Y,Yamashita R,Karasawa M,Watanabe Y,Ito Y

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Phosphodiesterase type IV (PDEIV) plays an important role in the immune response and inflammation. However, it is well known that classical PDEIV inhibitors have systemic side effects, so the clinical and chronic use of these agents as therapy for glomerulonephritis is difficult. This study was performed to ...

journal_title：Clinical and experimental nephrology

authors： Sadakane C,Kase Y,Koseki J,Hasegawa Y,Shindo S,Maruyama H,Takeda S,Takeda H,Hattori T

更新日期：2011-02-01 00:00:00

abstract：:A 52-year-old Japanese female was admitted to our hospital for microhematuria, proteinuria and progressive renal dysfunction. Two years prior to admission, she was diagnosed with lung adenocarcinoma and multiple bone and brain metastases, and was treated with gefitinib (250 mg/day). Treatment for 6 months induced part...

journal_title：Clinical and experimental nephrology

authors： Masutani K,Fujisaki K,Maeda H,Toyonaga J,Inoshima I,Takayama K,Katafuchi R,Hirakata H,Tsuruya K,Iida M

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Injection of parathyroid hormone (PTH) rapidly stimulates renal Pi excretion, in part by downregulating NaPi-IIa (Npt2a/SLC34A1) and NaPi-IIc (Npt2c/SLC34A3) transporters. The mechanisms underlying the effects of PTH on NaPi-IIc are not fully elucidated. METHODS:We analyzed the effect of PTH on inorganic ph...

journal_title：Clinical and experimental nephrology

authors： Fujii T,Segawa H,Hanazaki A,Nishiguchi S,Minoshima S,Ohi A,Tominaga R,Sasaki S,Tanifuji K,Koike M,Arima Y,Shiozaki Y,Kaneko I,Ito M,Tatsumi S,Miyamoto KI

更新日期：2019-07-01 00:00:00

abstract：:The manifestation of diabetic nephropathy may be a consequence of the actions of certain cytokines and growth factors. Prominent among them is transforming growth factor-β (TGF-β), which promotes renal cell hypertrophy and stimulates extracellular matrix accumulation, the two hallmarks of diabetic renal disease. In ex...

journal_title：Clinical and experimental nephrology

authors： Ziyadeh FN,Isono M,Chen S

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Renin-angiotensin system blockers (RASBs) reduce end-stage kidney disease and cardiovascular event (CVE) development in chronic kidney disease. However, whether RASBs improve long-term prognosis in kidney transplant (KT) recipients remain unknown. METHOD:We investigated 900 kidney transplant patients in a m...

journal_title：Clinical and experimental nephrology

authors： Tsuchimoto A,Masutani K,Ueki K,Nakagawa K,Matsukuma Y,Tanaka S,Unagami K,Kakuta Y,Okumi M,Noguchi H,Kaku K,Okabe Y,Nakano T,Kitazono T,Nakamura M,Ishida H,Tanabe K,Japan Academic Consortium of Kidney Transplantation (JA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Stromal cell-derived factor-1α (SDF-1α) is an inflammatory chemokine that plays a critical role in cardiovascular disease. Although persistent inflammation causes renal dysfunction, it remains unclear whether SDF-1α is related to progression of chronic kidney disease. This study examined whether high levels ...

journal_title：Clinical and experimental nephrology

authors： Uematsu M,Nakamura T,Yoshizaki T,Watanabe Y,Deyama J,Watanabe K,Kobayashi T,Fujioka D,Saito Y,Nakamura K,Kawabata K,Obata JE,Kugiyama K

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Although acute kidney injury (AKI) is known as a potential complication of influenza infections, there is limited information concerning the association between influenza and AKI. The aim of this study is to evaluate the incidence, the mortality, and risk factors of AKI in hospitalized patients by seasonal i...

journal_title：Clinical and experimental nephrology

authors： Ishibuchi K,Fukasawa H,Kaneko M,Yasuda H,Furuya R

更新日期：2021-01-04 00:00:00

abstract：:A 62-year-old female dialysis patient with chronic glomerulonephritis had been receiving hemodialysis therapy for 32 years. In 1985 she underwent a parathyroidectomy for secondary hyperparathyroidism (HPT); however, her parathyroid hormone (PTH) levels gradually increased. Her serum calcium level ranged from 9.0 to 10...

journal_title：Clinical and experimental nephrology

authors： Oshiro Y,Tanaka H,Okimoto N

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that selectively inhibits the reabsorption of uric acid in renal tubules and promotes the excretion of uric acid into urine. In this study, the effects of age and gender on the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotin...

journal_title：Clinical and experimental nephrology

authors： Nakatani H,Fushimi M,Sasaki T,Okui D,Ohashi T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Serum anion gap (AG) has recently been proven to represent a biomarker for predicting prognosis in patients with end-stage renal disease (ESRD). However, whether change in AG (ΔAG) at the time of starting hemodialysis predicts mortality after starting hemodialysis in elderly patients with ESRD remains unknow...

journal_title：Clinical and experimental nephrology

authors： Arai Y,Tanaka H,Shioji S,Sakamoto E,Kondo I,Suzuki M,Katagiri D,Tada M,Hinoshita F

更新日期：2020-05-01 00:00:00

abstract：:Dyslipidemia is an established risk factor for atherosclerotic disease, such as stroke and ischemic heart disease, and is often detected in patients with chronic kidney disease (CKD). The role of dyslipidemia in CKD progression, however, is not well understood. CKD patients are heterogeneous and may include those who ...

journal_title：Clinical and experimental nephrology

authors： Iseki K

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Low-energy extracorporeal shock wave (SW) improves ventricular function in ischemic cardiomyopathy through the upregulation of vascular endothelial growth factor (VEGF). VEGF is known to play important roles in acute kidney injury (AKI), and the present study investigates the efficacy of SW for AKI by renal ...

journal_title：Clinical and experimental nephrology

authors： Yoshida M,Nakamichi T,Mori T,Ito K,Shimokawa H,Ito S

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Genetic susceptibility to atypical hemolytic uremic syndrome (aHUS) may lie within genes regulating or activating the alternate complement and related pathways converging on endothelial cell activation. METHODS:We tested 32 Indian patients of aHUS negative for antibodies to complement factor H for genetic v...

journal_title：Clinical and experimental nephrology

authors： Thergaonkar RW,Narang A,Gurjar BS,Tiwari P,Puraswani M,Saini H,Sinha A,Varma B,Mukerji M,Hari P,Bagga A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Although neutrophil-to-lymphocyte ratio (NLR) is closely associated with pneumonia in the general population, its relationship is unclear in peritoneal dialysis (PD) patients. METHODS:This is a cohort study consisting of 739 PD patients and dividing into two groups. Kaplan-Meier curves were applied to obser...

journal_title：Clinical and experimental nephrology

authors： Zhang Y,Lai X,Chen Q,Zhan X,Long H,Peng F,Zhang F,Feng X,Zhou Q,Wu X,Liu L,Wang Z,ETNA.,Peng X,Hu K,Wang D,Guo G,Zeng Y,Wen Y,Liang J

更新日期：2020-09-01 00:00:00

abstract：:Sarcoidosis is a systemic granulomatous disease of unknown etiology and is associated with a wide variety of renal disorders including nephrolithiasis, hypercalciuria, hypercalcemia, nephrocalcinosis, tubular defect, glomerulonephritis, and granulomatous interstitial nephritis. We report a case of renal sarcoidosis in...

journal_title：Clinical and experimental nephrology

authors： Mitome J,Kawaguchi Y,Arase S,Horino T,Okada H,Osaka N,Hanaoka K,Shimada T,Kawamura T,Hosoya T,Yamaguchi Y,Hano H

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct. Multiple phosphorylation sites are present at the C-terminal of AQP2 including S256 (serine at 256 residue), S261, S264 and S/T269, which are regulated by vasopressin (VP) to modulate AQP2 traffi...

journal_title：Clinical and experimental nephrology

authors： Sakai M,Yamamoto K,Mizumura H,Matsumoto T,Tanaka Y,Noda Y,Ishibashi K,Yamamoto T,Sasaki S

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Dotinurad is a novel, selective urate reabsorption inhibitor (SURI), which reduces serum uric acid levels by selective inhibition of the urate transporter 1 (URAT1). The Japanese guideline for the management of hyperuricemia and gout recommends that drug selection should be based on classification of hyperur...

journal_title：Clinical and experimental nephrology

authors： Hosoya T,Furuno K,Kanda S

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Although a high prevalence of macrovascular disease (MVD) has been reported in patients with stage 3 chronic kidney disease (CKD), few studies have reported its risk with respect to the underlying cause of kidney disease. This study investigated the prevalence of MVD in type 2 diabetic patients with CKD stra...

journal_title：Clinical and experimental nephrology

authors： Tanaka K,Hara S,Kushiyama A,Ubara Y,Yoshida Y,Mizuiri S,Aikawa A,Kawatzu S

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Peritoneal injury is an important cause of technical failure of long-term peritoneal dialysis (PD). Encapsulating peritoneal sclerosis (EPS) is a severe complication of long-term PD with potentially life threatening consequences. CD147 is a glycoprotein with diverse functions including modulation of extracel...

journal_title：Clinical and experimental nephrology

authors： Seeger H,Latus J,Kitterer D,Alscher MD,Biegger D,Chen J,Edenhofer I,Wüthrich RP,Segerer S

更新日期：2017-12-01 00:00:00