Effects of TJN-598, a new selective phosphodiesterase type IV inhibitor on anti-Thy1 nephritis in rats.

abstract：:Both thin basement membrane nephropathy (TBMN) and autosomal dominant Alport syndrome (ADAS) are types of hereditary nephritis resulting from heterozygous mutations in COL4A3 or COL4A4 genes. Although TBMN is characterized by hematuria and thinning of the glomerular basement membrane (GBM) with excellent renal prognos...

journal_title：Clinical and experimental nephrology

authors： Imafuku A,Nozu K,Sawa N,Nakanishi K,Ubara Y

更新日期：2020-08-01 00:00:00

abstract：:A 52-year-old Japanese female was admitted to our hospital for microhematuria, proteinuria and progressive renal dysfunction. Two years prior to admission, she was diagnosed with lung adenocarcinoma and multiple bone and brain metastases, and was treated with gefitinib (250 mg/day). Treatment for 6 months induced part...

journal_title：Clinical and experimental nephrology

authors： Masutani K,Fujisaki K,Maeda H,Toyonaga J,Inoshima I,Takayama K,Katafuchi R,Hirakata H,Tsuruya K,Iida M

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Tolvaptan slowed the rates of total kidney volume (TKV) growth and renal function decline over a 3-year period in patients with autosomal dominant polycystic kidney disease (ADPKD) enrolled in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes (TE...

journal_title：Clinical and experimental nephrology

authors： Horie S,Muto S,Kawano H,Okada T,Shibasaki Y,Nakajima K,Ibuki T

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND:Cardiovascular disease is the leading cause of morbidity and mortality in patients with kidney failure. Nocturnal home hemodialysis (NHD) is a form of kidney replacement therapy whereby hemodialysis is performed for at least 6-h overnight, at least 4 days per week. Little is known about the effects of NHD on...

journal_title：Clinical and experimental nephrology

authors： Friesen T,Jassal DS,Zhu M,Eng F,Rigatto C,Tangri N,Sood MM,Karlstedt E,Premecz S,Komenda P

更新日期：2015-06-01 00:00:00

abstract：:A 61-year-old man infected with hepatitis C virus developed urinary protein. Two-dimensional electrophoresis and immunoblotting of sera revealed no monoclonal proteins. Light microscopy and immunofluorescence of a kidney biopsy specimen demonstrated bubbling appearance and formation of spikes, associated with predomin...

journal_title：Clinical and experimental nephrology

authors： Miura N,Uemura Y,Suzuki N,Suga N,Maeda K,Yamaguchi S,Kitagawa W,Yamada H,Nishikawa K,Imai H

更新日期：2010-02-01 00:00:00

abstract：:The case of a 63-year-old woman with a relatively rapidly growing angiomyolipoma (AML) originating from the right renal sinus is presented. The tumor had enlarged to more than fivefold in volume (7.4 × 6.7 × 10.1 cm) in the 7 years following its detection (5.6 × 3.4 × 4.6 cm) and had significantly pushed aside the duo...

journal_title：Clinical and experimental nephrology

authors： Shirotake S,Yoshimura I,Kosaka T,Matsuzaki S

更新日期：2011-12-01 00:00:00

abstract：:A 62-year-old female dialysis patient with chronic glomerulonephritis had been receiving hemodialysis therapy for 32 years. In 1985 she underwent a parathyroidectomy for secondary hyperparathyroidism (HPT); however, her parathyroid hormone (PTH) levels gradually increased. Her serum calcium level ranged from 9.0 to 10...

journal_title：Clinical and experimental nephrology

authors： Oshiro Y,Tanaka H,Okimoto N

更新日期：2011-08-01 00:00:00

abstract：:A 77-year-old Japanese female developed Churg-Strauss syndrome (CSS), showing fever and numbness in bilateral hands. She was being treated for bronchial asthma with combination inhalant of corticosteroid with beta(2)-agonist, and an oral leukotriene receptor antagonist (LTRA), montelukast, for 15 months. She presented...

journal_title：Clinical and experimental nephrology

authors： Kanda T,Tanio H,Wu C,Nishihara H,Nogaki F,Ono T

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Pulmonary-renal syndrome is characterized by pulmonary hemorrhage and rapidly progressive glomerulonephritis in various immunological states. Histopathological analysis of pulmonary-renal syndrome is not yet complete. METHODS:Wistar-Kyoto (WKY) rats were sensitized using the noncollagenous (NC1) domain of t...

journal_title：Clinical and experimental nephrology

authors： Aoyagi D,Nakazawa K,Kaneyama T,Masumoto J,Otani M,Shigematsu H

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Erythropoiesis-stimulating agent (ESA) responsiveness is related to the nutritional status of patients on hemodialysis (HD). Serum butyrylcholinesterase (BChE), an alpha-glycoprotein, may decrease in case of malnutrition. We investigated whether BChE was independently related to ESA resistance in patients on...

journal_title：Clinical and experimental nephrology

authors： Okamoto T,Hatakeyama S,Tanaka Y,Imanishi K,Takashima T,Saitoh F,Koie T,Suzuki T,Ohyama C

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Recently, preemptive kidney transplantation (PKT) has increased in Japan; however, the effects of PKT on calcium (Ca) and phosphorus (Pi) metabolism are poorly understood. METHODS:Thirty-two consecutive patients were enrolled in this study at Nagoya Daini Red Cross Hospital. Fifteen patients were in the PKT...

journal_title：Clinical and experimental nephrology

authors： Tsujita M,Inaguma D,Goto N,Yamamoto T,Hiramitsu T,Katayama A,Takeda A,Kobayashi T,Morozumi K,Uchida K,Narumi S,Watarai Y,Tominaga Y

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Renal inulin clearance is the gold standard for glomerular filtration rate (GFR), but is compromised by problems of collecting urine samples in children, especially those <6 years of age or with a bladder dysfunction. Therefore, we should utilize the serum creatinine (Cr)-based estimated GFR (eGFR), measurin...

journal_title：Clinical and experimental nephrology

authors： Nagai T,Uemura O,Ishikura K,Ito S,Hataya H,Gotoh Y,Fujita N,Akioka Y,Kaneko T,Honda M

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor common to both chronic kidney disease and cardiovascular disease. Nicorandil is widely used for the treatment of angina. We investigated the benefits of nicorandil with respect to renal dysfunction in Dahl salt-sensitive hypertensive (DS) rats. METHOD:DS rats were fed a high-sa...

journal_title：Clinical and experimental nephrology

authors： Tashiro Y,Yogo K,Serizawa K,Endo K

更新日期：2015-06-01 00:00:00

abstract：:Chronic kidney disease (CKD), as defined by reduced glomerular filtration rate (<60 ml/min/1.73 m(2)) and/or the presence of renal damage for >3 months, is a significant threat for public health in modern societies. Recent epidemiological studies have demonstrated that CKD is a significant risk for cardiovascular even...

journal_title：Clinical and experimental nephrology

authors： Ito S

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Aging is well known as one of the major causes of a reduced glomerular filtration rate (GFR). The resistive index (RI) measured by renal Doppler ultrasonography (RDU) is thought to be a good indicator of renal vascular resistance induced by arteriosclerosis. In this study, we investigated whether RI could be...

journal_title：Clinical and experimental nephrology

authors： Kawai T,Kamide K,Onishi M,Hongyo K,Yamamoto-Hanasaki H,Oguro R,Maekawa Y,Yamamoto K,Takeya Y,Sugimoto K,Ohishi M,Rakugi H

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVES:Interleukin (IL)-33 plays an important role in host defense, immune regulation, and inflammation. This study assessed IL-33's role in the pathogenesis of severe hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli (EHEC). We also investigated the clinical significance of IL-33 and so...

journal_title：Clinical and experimental nephrology

authors： Yamada S,Shimizu M,Kuroda M,Inoue N,Sugimoto N,Yachie A

更新日期：2019-04-01 00:00:00

abstract：:A 69-year-old Caucasian man was admitted to our hospital because of myocardial infarction. A central venous catheter (CVC) for infusive therapy was inserted. After two weeks he developed fever, purpura, and knee arthralgia. Hemoculture yielded methicillin-sensitive Staphylococcus aureus. Subsequently, oliguric renal f...

journal_title：Clinical and experimental nephrology

authors： Uggeri S,Fabbian F,Catizone L

更新日期：2008-06-01 00:00:00

abstract：:Microscopic polyangiitis is a necrotizing angiitis involving capillaries, venules, and arterioles. The vascular beds of various organs may be involved, causing varying presentations. To our knowledge, this is the first case of anti-myeloperoxidase (anti-MPO) antibody small-vessel vasculitis causing prostatic vasculiti...

journal_title：Clinical and experimental nephrology

authors： Lamarche JA,Peguero AM,Rosario JO,Patel A,Courville C

更新日期：2007-06-01 00:00:00

abstract：:We report a 58-year-old Japanese man with primary systemic AL amyloidosis who achieved disappearance of proteinuria including Bence-Jones protein (lambda-type) after two courses of VAD therapy (vincristine, doxorubicin, and dexamethasone) and subsequent high-dose melphalan, followed by autologous peripheral blood stem...

journal_title：Clinical and experimental nephrology

authors： Yamazaki O,Ubara Y,Suwabe T,Nakanishi S,Hoshino J,Sawa N,Hayami N,Yamanouchi M,Takemoto F,Kenmei T,Masuoka K,Oohashi K

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Liposomal amphotericin B (L-AMB), a broad-spectrum antifungicidal drug, is often used to treat fungal infections. However, clinical evidence of its use in patients with renal dysfunction, especially those receiving renal replacement therapy (RRT), is limited. Therefore, we evaluated the usage and occurrence ...

journal_title：Clinical and experimental nephrology

authors： Obata Y,Takazono T,Tashiro M,Ota Y,Wakamura T,Takahashi A,Sato K,Miyazaki T,Nishino T,Izumikawa K

更新日期：2020-11-11 00:00:00

abstract：BACKGROUND:The incidence of childhood nephrotic syndrome (NS) in Germany is not well known. METHODS:An ESPED-based nationwide collection of epidemiological data of children in 2005 and 2006. RESULT:The mean age of NS at onset was 5.5 ± 3.7 years. The gender ratio of boys to girls was 1.8:1. The average length of stay...

journal_title：Clinical and experimental nephrology

authors： Franke I,Aydin M,Llamas Lopez CE,Kurylowicz L,Ganschow R,Lentze M,Born M

更新日期：2018-02-01 00:00:00

abstract：:A 57-year-old woman presented with fever and cellulitis of the right leg. Urinalysis and kidney function were normal on admission. Cellulitis remitted but fever persisted for six weeks. X-ray imaging, cultures, serological assays for viruses and autoimmunity did not reveal the cause of fever. Unexpectedly anti-Scl 70 ...

journal_title：Clinical and experimental nephrology

authors： Vega Stieb J,Goecke Saavedra H,Méndez Olivieri G

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Little is known concerning the risk of hospitalization and the risk of death before receiving dialysis by the stage of chronic kidney disease (CKD) in Japan. METHODS:The subjects comprised a total of 13,911 Japanese men (mean age 49.2 ± 9.9 years). Based on the results of a health checkup performed in 2006,...

journal_title：Clinical and experimental nephrology

authors： Nishikawa K,Takahashi K,Yamada R,Kinaga T,Masato M,Yamamoto M

更新日期：2017-04-01 00:00:00

abstract：:A 78-year old woman with complicating solitary kidney had nephrotic syndrome. Renal biopsy specimens showed focal segmental glomerulosclerosis (FSGS). First, the patient was treated with angiotensin receptor blocker (ARB) and angiotensin converting enzyme inhibitor (ACEI). Proteinuria decreased from 10 to 6 g/day, but...

journal_title：Clinical and experimental nephrology

authors： Oshiro Y,Umena S,Noda M

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Edaravone, a drug for treating acute ischemic stroke, has been reported to provoke acute renal disorders. In the previous study, the author evaluated the role of edaravone in the development of renal disorders in 207 patients reported as having developed them in the post-marketing survey of the drug. The ove...

journal_title：Clinical and experimental nephrology

authors： Hishida A

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Stromal cell-derived factor-1α (SDF-1α) is an inflammatory chemokine that plays a critical role in cardiovascular disease. Although persistent inflammation causes renal dysfunction, it remains unclear whether SDF-1α is related to progression of chronic kidney disease. This study examined whether high levels ...

journal_title：Clinical and experimental nephrology

authors： Uematsu M,Nakamura T,Yoshizaki T,Watanabe Y,Deyama J,Watanabe K,Kobayashi T,Fujioka D,Saito Y,Nakamura K,Kawabata K,Obata JE,Kugiyama K

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Because of the well-established annual urinalysis screening system in Japan, the duration of nephropathy (DN) can be estimated in more than half of all patients with IgA nephropathy (IgAN). Treatment using a combination of tonsillectomy and steroid pulse (TSP) therapy has been reported as an effective method...

journal_title：Clinical and experimental nephrology

authors： Ieiri N,Hotta O,Sato T,Taguma Y

更新日期：2012-02-01 00:00:00

abstract：:Glomerular lipid deposition is sometimes associated with a particular kind of lipid metabolism disturbance. Ultrastructural analyses using electron microscopy often indicate a disease-specific aspect of intraglomerular lipid distribution. ...

journal_title：Clinical and experimental nephrology

authors： Sato H,Takahashi N,Sato E,Kisu K,Ito S,Saito T

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Serum anion gap (AG) has recently been proven to represent a biomarker for predicting prognosis in patients with end-stage renal disease (ESRD). However, whether change in AG (ΔAG) at the time of starting hemodialysis predicts mortality after starting hemodialysis in elderly patients with ESRD remains unknow...

journal_title：Clinical and experimental nephrology

authors： Arai Y,Tanaka H,Shioji S,Sakamoto E,Kondo I,Suzuki M,Katagiri D,Tada M,Hinoshita F

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Peritoneal dialysis (PD) exchange procedure is complex. Patients with cognitive impairment (CI) may require assistance. We studied the prevalence of CI among PD patients, its impact on PD-related peritonitis and the outcome of assisted PD. METHODS:Cantonese version of Mini-Mental State examination (CMMSE) w...

journal_title：Clinical and experimental nephrology

authors： Shea YF,Lam MF,Lee MS,Mok MY,Lui SL,Yip TP,Lo WK,Chu LW,Chan TM

更新日期：2016-02-01 00:00:00