Abstract:
BACKGROUND:Erythropoiesis-stimulating agent (ESA) responsiveness is related to the nutritional status of patients on hemodialysis (HD). Serum butyrylcholinesterase (BChE), an alpha-glycoprotein, may decrease in case of malnutrition. We investigated whether BChE was independently related to ESA resistance in patients on HD. METHODS:The laboratory data and ESA resistance index (ERI), defined as ESA dosage per week divided by dry weight and hemoglobin, were investigated in 215 patients on HD between July and September 2017. Malnutrition was defined as Geriatric Nutritional Risk Index (GNRI) of < 91.2. The patients were stratified into two groups: ERI-high (ERI ≥ 9.44) and ERI-low (ERI < 9.44) groups. Variables such as patient's background, medication, and laboratory data were compared between the two groups. The optimal cutoff value of BChE for higher ERI was determined using receiver operating characteristic analysis. Factors independently associated with higher ERI were determined using multivariate logistic regression analysis. RESULTS:The median and optimal cutoff values of ERI and BChE were 6.51 and 200 IU/L, respectively. The study included 71 (33%) and 144 (67%) patients in the ERI-high and ERI-low groups, respectively. Significant between-group differences were observed concerning age, hemoglobin, ESA dose, lipid profiles, serum albumin, body mass index, GNRI, iron metabolism markers, ferric medicines, and BChE. Multivariate analysis showed that BChE < 200 IU/L (odds ratio 3.67; 95% confidence interval 1.73-7.77) continued to be an independent factor associated with higher ERI after adjusting for potential confounders, which was a similar odds ratio as GNRI < 91.2. CONCLUSION:BChE may be an independent indicator of ESA resistance.
journal_name
Clin Exp Nephroljournal_title
Clinical and experimental nephrologyauthors
Okamoto T,Hatakeyama S,Tanaka Y,Imanishi K,Takashima T,Saitoh F,Koie T,Suzuki T,Ohyama Cdoi
10.1007/s10157-018-1569-zsubject
Has Abstractpub_date
2018-10-01 00:00:00pages
1174-1181issue
5eissn
1342-1751issn
1437-7799pii
10.1007/s10157-018-1569-zjournal_volume
22pub_type
杂志文章abstract::A 69-year-old woman presented with unusual electron microscopic findings. The patient was admitted to ascertain the cause of her persistent proteinuria, and kidney biopsy was performed. While light microscopic findings and immunofluorescence study suggested membranous nephropathy, electron microscopic study showed mic...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
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abstract:BACKGROUND:Hypertriglyceridemia (hTG) is a risk factor for progression of chronic kidney disease (CKD); however, it remains unknown whether the adipocytokine complement component 3 (C3) is involved in the association between hTG and CKD. METHODS:The study included 138 patients (54 % male) with non-nephrotic (serum alb...
journal_title:Clinical and experimental nephrology
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doi:10.1007/s10157-013-0825-5
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journal_title:Clinical and experimental nephrology
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journal_title:Clinical and experimental nephrology
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doi:10.1007/s10157-017-1387-8
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Although recovery of renal function after an episode of acute kidney injury (AKI) is an important clinical measure of morbidity, predictors of withdrawal from renal replacement therapy (RRT) among AKI patients remain unclear. METHODS:In this single-center retrospective cohort study, we examined the clinical...
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abstract:BACKGROUND:The appropriate blood pressure target to prevent end-stage renal disease (ESRD) is controversial. METHODS:We examined the association between systolic blood pressure (SBP) changes and ESRD incidence in 69,575 participants from the Okinawa general population aged ≥ 20 years who underwent health check-ups in ...
journal_title:Clinical and experimental nephrology
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Clinical and experimental nephrology
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journal_title:Clinical and experimental nephrology
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journal_title:Clinical and experimental nephrology
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journal_title:Clinical and experimental nephrology
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
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journal_title:Clinical and experimental nephrology
pub_type: 临床试验,杂志文章
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journal_title:Clinical and experimental nephrology
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更新日期:2005-03-01 00:00:00
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