Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease.

abstract：:A 52-year-old Japanese female was admitted to our hospital for microhematuria, proteinuria and progressive renal dysfunction. Two years prior to admission, she was diagnosed with lung adenocarcinoma and multiple bone and brain metastases, and was treated with gefitinib (250 mg/day). Treatment for 6 months induced part...

journal_title：Clinical and experimental nephrology

authors： Masutani K,Fujisaki K,Maeda H,Toyonaga J,Inoshima I,Takayama K,Katafuchi R,Hirakata H,Tsuruya K,Iida M

更新日期：2008-10-01 00:00:00

abstract：:A 68-year-old man with a 30-year history of essential thrombocytosis developed nephrotic syndrome. Renal biopsy showed massive deposits of Congo red-negative periodic acid Schiff (PAS)-positive substance in the mesangium and capillary wall that was positive for IgG. Electron microscopic examination revealed 10- to 20-...

journal_title：Clinical and experimental nephrology

authors： Asaba K,Tojo A,Onozato ML,Mimura N,Kido M,Goto A,Endo H,Fujita T

更新日期：2003-12-01 00:00:00

abstract：:IgA nephropathy (IgAN) associated with leukemia and lymphoma has not, to our knowledge, been reported in children. Two children suffering from these diseases are described here. One patient developed IgAN at the end of 5 years' chemotherapy for acute lymphocytic leukemia. The other had microscopic hematuria 3 years be...

journal_title：Clinical and experimental nephrology

authors： Motoyama O,Kojima Y,Ohara A,Tsukimoto I,Ishikawa Y,Iitaka K

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Sirt1, a mammalian homolog of silent information regulator 2 (Sir2), is the founding member of class III histone deacetylase (HDAC). METHODS:In this study, we examined whether Sirt1 is involved in the modification of acetylated histone H3, acetylated p53 and Werner syndrome protein (WRN), which is stabilize...

journal_title：Clinical and experimental nephrology

authors： Sakao Y,Kato A,Tsuji T,Yasuda H,Togawa A,Fujigaki Y,Kahyo T,Setou M,Hishida A

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Edaravone, a drug for treating acute ischemic stroke, has been reported to provoke acute renal disorders. In the previous study, the author evaluated the role of edaravone in the development of renal disorders in 207 patients reported as having developed them in the post-marketing survey of the drug. The ove...

journal_title：Clinical and experimental nephrology

authors： Hishida A

更新日期：2009-04-01 00:00:00

abstract：:We report a case of acute kidney injury (AKI) caused by a novel direct renin inhibitor, aliskiren. A 43-year-old Japanese man with dilated cardiomyopathy on cardiac resynchronization therapy with defibrillator and chronic kidney disease (CKD) was started on aliskiren in addition to enalapril, carvedilol, furosemide, a...

journal_title：Clinical and experimental nephrology

authors： Yamauchi J,Shibagaki Y,Uehara K,Yasuda T,Kimura K

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Guidelines for treatment of hypertension are not available for chronic hemodialysis (HD) population, despite the high mortality rate due to cardiovascular disease (CVD). Survival is much better among hypertensive patients than normal to hypotensive patients. Target levels of blood pressure and the class of a...

journal_title：Clinical and experimental nephrology

authors： Iseki K,Tokuyama K,Shiohira Y,Higa A,Hirano H,Toma S,Kohagura K,Ueda S

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:The post-marketing surveillance of edaravone has reported serious adverse reactions, including renal and hepatic disorders. Renal disorders were the most frequently reported serious/important adverse reactions, which led to the evaluation of their causation by edaravone, their severity, and the recovery of r...

journal_title：Clinical and experimental nephrology

authors： Hishida A

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:In order to clarify the interaction between cardiac dysfunction and sodium homeostasis in the kidney, we used a murine model of cardiac dysfunction and investigated the effect on sodium transporters in renal tubular cells. METHODS:Cardiac function was deteriorated by abdominal aortic banding, and the gene e...

journal_title：Clinical and experimental nephrology

authors： Tsuchida Y,Kaneko Y,Otsuka T,Goto K,Saito A,Yamamoto K,Yamamoto T,Narita I

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Skin and soft tissue infection (SSTI) is the most common of infectious diseases with high morbidity and mortality. However, the clinical characteristics of SSTI in patients with nephrotic syndrome (NS), especially in those patients who received immunosuppressive therapy, are still lacking. The present study w...

journal_title：Clinical and experimental nephrology

authors： Hu T,Wang M,Chen W,Zhao J,Xiong J

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Adenosine monophosphate (AMP)-activated protein kinase (AMPK), as a sensor of cellular energy status, has been known to play an important role in the pathophysiology of diabetes and its complications. As AMPK is also expressed in podocytes, it is possible that podocyte AMPK would be an important contributing...

journal_title：Clinical and experimental nephrology

authors： Choi JY,Ha TS,Park HY,Ahn HY

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:In 2013, eculizumab was approved for treatment of the atypical hemolytic-uremic syndrome (aHUS) in Japan, which was defined as a thrombotic microangiopathy (TMA) excluding Shiga toxin-producing Escherichia coli-HUS and thrombotic thrombocytopenic purpura. Simultaneously, post-marketing surveillance was start...

journal_title：Clinical and experimental nephrology

authors： Ito S,Hidaka Y,Inoue N,Kaname S,Kato H,Matsumoto M,Miyakawa Y,Mizuno M,Okada H,Shimono A,Matsuda T,Maruyama S,Fujimura Y,Nangaku M,Kagami S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The incidence of hypocomplementemia detected in the school urinary screening program in Kanagawa Prefecture, Japan, and the number of new patients with membranoproliferative glomerulonephritis (MPGN) diagnosed in our institution were decreasing during the period between 1974 and 1997. Follow-up of this study...

journal_title：Clinical and experimental nephrology

authors： Iitaka K,Nakamura S,Moriya S,Koshino H,Iwanami N,Sakai T,Motoyama O

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:X-linked Alport syndrome (XLAS) is a progressive hereditary nephropathy caused by mutations in the type IV collagen alpha chain 5 gene (COL4A5). Although many COL4A5 mutations have previously been identified, pathogenic synonymous mutations have not yet been described. METHODS:A family with XLAS underwent m...

journal_title：Clinical and experimental nephrology

authors： Fu XJ,Nozu K,Eguchi A,Nozu Y,Morisada N,Shono A,Taniguchi-Ikeda M,Shima Y,Nakanishi K,Vorechovsky I,Iijima K

更新日期：2016-10-01 00:00:00

abstract：:A 33-year-old woman was transferred to our hospital with a 5-month history of taking Chinese herbal medicine containing aristolochic acid. She presented with metabolic acidosis, severe anemia, hypophosphatemia and uric aciduria, and generalized aminoaciduria and glycosuria, features which were consistent with the clin...

journal_title：Clinical and experimental nephrology

authors： Kazama I,Matsubara M,Michimata M,Suzuki M,Hatano R,Sato H,Ito S

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Analyses of selected cases suggest that immunosuppressive treatment could reduce proteinuria and delay the progression of immunoglobulin A nephropathy (IgAN). The aim of this study was to examine the long-term effectiveness of this therapy on the clinical course of IgAN. We also examined the relationship bet...

journal_title：Clinical and experimental nephrology

authors： Oshima S,Kawamura O

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Type 2 diabetic kidney disease (DKD) is the most common cause of end-stage renal failure, and the prevention of its progression has been a topic of discussion. METHODS:Sixty type 2 DKD patients were retrospectively evaluated for 1 year. Factors independently affecting the annual Ccr decline were examined by...

journal_title：Clinical and experimental nephrology

authors： Kanauchi N,Ookawara S,Ito K,Mogi S,Yoshida I,Kakei M,Ishikawa SE,Morishita Y,Tabei K

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Myeloid-derived suppressor cells (MDSCs) have been identified as immunosuppressive cells in tumor-related inflammation. However, the pathogenesis of MDSCs for autoimmune disease has not been investigated as yet. The aim of this study was to address whether MDSCs contribute to autoimmune organ injury in lupus-...

journal_title：Clinical and experimental nephrology

authors： Iwata Y,Furuichi K,Kitagawa K,Hara A,Okumura T,Kokubo S,Shimizu K,Sakai N,Sagara A,Kurokawa Y,Ueha S,Matsushima K,Kaneko S,Wada T

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The number of patients with chronic kidney disease (CKD) in Japan is currently rising. Therefore, measures to control the progression of CKD from a predialysis condition to endstage renal failure are urgently required. We are conducting a clinical trial to investigate the efficacy of an oral carbonaceous ads...

journal_title：Clinical and experimental nephrology

authors： Morita S,Fukuhara S,Akizawa T,Asano Y,Kurokawa K

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVES:Interleukin (IL)-33 plays an important role in host defense, immune regulation, and inflammation. This study assessed IL-33's role in the pathogenesis of severe hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli (EHEC). We also investigated the clinical significance of IL-33 and so...

journal_title：Clinical and experimental nephrology

authors： Yamada S,Shimizu M,Kuroda M,Inoue N,Sugimoto N,Yachie A

更新日期：2019-04-01 00:00:00

abstract：AIM:IgA nephropathy (IgAN) is a very common glomerulonephritis among young adults, but the best therapeutic approach has not been fully elucidated. This study evaluated the effect of two different treatment regimes in IgAN, steroids alone or in combination with azathioprine. METHODS:Among 122 patients with primary IgA...

journal_title：Clinical and experimental nephrology

authors： Stangou M,Ekonomidou D,Giamalis P,Liakou H,Tsiantoulas A,Pantzaki A,Papagianni A,Efstratiadis G,Alexopoulos E,Memmos D

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:The definition of sepsis was updated to sepsis-3 in February 2016. Currently, direct hemoperfusion therapy using the polymyxin B-immobilized fiber cartridge (PMX-DHP) is widely performed to treat sepsis and septic shock. However, the prognostic factors of PMX-DHPs in patients with sepsis using the new defini...

journal_title：Clinical and experimental nephrology

authors： Okubo A,Nakashima A,Doi S,Ueno T,Sasaki K,Esaki T,Masaki T

更新日期：2018-10-01 00:00:00

abstract：:We describe here two sisters with nephronophthisis, which was not detected until the development of endstage renal failure. Twenty- and 15-year-old female siblings were admitted to our hospital for further examination of renal dysfunction. No urinalysis abnormalities had been found in yearly health checks in either pa...

journal_title：Clinical and experimental nephrology

authors： Ashizawa M,Miyazaki M,Furusu A,Abe K,Kanamoto Y,Iwanaga N,Ozono Y,Harada T,Taguchi T,Kohno S

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 (CoQ10). METHODS:Three-week-old heminephrectomized male Sprague-Dawley rats were divided into three groups (10 animals each): diet with normal (0.3%) salt, high (8%) salt, and high salt plus 60...

journal_title：Clinical and experimental nephrology

authors： Ishikawa A,Kawarazaki H,Ando K,Fujita M,Fujita T,Homma Y

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Hyperuricemia is an established risk factor for cardiovascular events and mortality. This study investigated the association between serum uric acid and the incidence of nonfatal stroke in a Japanese community-based population. METHODS:We used a nationwide database of 155,322 subjects (aged 40-73, male 39 %...

journal_title：Clinical and experimental nephrology

authors： Kamei K,Konta T,Hirayama A,Ichikawa K,Kubota I,Fujimoto S,Iseki K,Moriyama T,Yamagata K,Tsuruya K,Narita I,Kondo M,Shibagaki Y,Kasahara M,Asahi K,Watanabe T

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Contrast media (CM)-induced nephropathy (CIN) is an acute deterioration of renal function following administration of CM mediated to a large extent by the increased production of ROS within the kidney. Aim of this study was to evaluate whether a novel isoform of a recombinant Manganese SOD (rMnSOD) could pro...

journal_title：Clinical and experimental nephrology

authors： Pisani A,Sabbatini M,Riccio E,Rossano R,Andreucci M,Capasso C,De Luca V,Carginale V,Bizzarri M,Borrelli A,Schiattarella A,Santangelo M,Mancini A

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND AIM:The infusion of chronic angiotensin II (Ang II) has been shown to promote renal interstitial fibrosis. To evaluate the pathophysiological significance of the natriuretic peptide-GC-A system, we infused Ang II (1.0 mg/kg/day) in GC-A-deficient mice (GC-A-KO). METHODS:We used 5 groups (Wild-Saline n =...

journal_title：Clinical and experimental nephrology

authors： Yoshihara F,Tokudome T,Kishimoto I,Otani K,Kuwabara A,Horio T,Kawano Y,Kangawa K

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that GFR estimated from serum creatinine (eGFRcr) is higher in smokers although the implications remain unclear. We aimed to clarify the associations of smoking with eGFRcys (GFR estimated from serum cystatin C) and eGFRcr, cys (the surmised most precise GFR estimate based on seru...

journal_title：Clinical and experimental nephrology

authors： Yamada Y,Noborisaka Y,Ishizaki M,Yamazaki M,Honda R,Yokoyama H,Kakuma T

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The current (2012) histological classification of immunoglobulin A nephropathy was established using a case-control study of 287 patients. However, the risk of progression to end-stage renal disease (ESRD) has not been validated for the previous (2002) classification. This study aimed to determine whether th...

journal_title：Clinical and experimental nephrology

authors： Miyazaki Y,Kawamura T,Joh K,Okonogi H,Koike K,Utsunomiya Y,Ogura M,Matsushima M,Yoshimura M,Horikoshi S,Suzuki Y,Furusu A,Yasuda T,Shirai S,Shibata T,Endoh M,Hattori M,Akioka Y,Katafuti R,Hashiguchi A,Kimura K,M

更新日期：2014-06-01 00:00:00

abstract：:Unique renal histopathological appearances, consisting of podocytic infolding and microstructures in the glomerular basement membrane (GBM) were identified in the renal biopsies from three patients with collagen diseases such as systemic lupus erythematosus (lupus nephritis, class II) and Sjögren's syndrome. In each c...

journal_title：Clinical and experimental nephrology

authors： Sugiyama H,Maruyama M,Morinaga H,Inoue T,Takiue K,Kikumoto Y,Kinomura M,Sada KE,Akagi S,Kitamura S,Maeshima Y,Makino H

更新日期：2008-12-01 00:00:00